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H5N1 bird flu virus is changing

AlaskaDenise

In Memoriam
http://www.fao.org/newsroom/en/news/2006/1000438/index.html

FAO and OIE recommend increased surveillance when vaccinating

8 November 2006, Paris/Rome - According to a report in last week?s Proceedings of the National Academy of Sciences on the identification of a new H5N1 virus sublineage in poultry, this new virus sublineage, called Fujian virus, appears to have become the dominant strain of the H5N1 avian influenza circulating in parts of Asia. If the report is confirmed, this does not come as a surprise, FAO and the World Organisation for Animal Health (OIE) said today.

While there is a wide variety of avian influenza strains in animals, and influenza viruses in general have a high rate of change from season to season and from year to year, OIE Director-General Bernard Vallat and FAO?s Chief Veterinary Officer Joseph Domenech warn that with new antigens developing continually in avian influenza viruses, vaccines currently in use for poultry need to be assessed regularly.

The two organizations continue to recommend that vaccination control measures need to be accompanied by surveillance and post-vaccination monitoring. They also stressed the need to immediately report to veterinary authorities any unexpected poultry deaths.

Careful monitoring of vaccination campaigns recommended

Vaccination remains part of the FAO-OIE strategy to contain avian influenza and both organizations say that vaccination campaigns should be applied appropriately and carefully monitored according to FAO and OIE technical guidelines, including the use of a cold chain in order to protect the vaccine. Vaccination must be carried out along with other disease control measures, such as improved hygiene on the farm, animal movement management or market inspection and culling in case of outbreaks, said Dr Domenech.

According to Dr Vallat, ?Commitment is needed from all governments to implement prevention and control programmes such as surveillance of virus circulation and, where appropriate, vaccination programmes in countries where the virus is endemic or where there is a high risk of introduction of the virus.?

FAO and OIE are already supporting such programmes in key countries where the virus is still circulating. But, they say more information on control programmes based on vaccination is needed and urge more research be funded to better understand the epidemiology and genetic changes of the H5N1 virus

Data sharing

FAO, the OIE and a myriad of scientific experts on avian influenza have repeatedly called upon scientists around the world to share their findings and virus strains in a timely and transparent fashion. The OIE/FAO Avian Influenza Laboratory Network with its secretariat in Padova, Italy (OFFLU - http://www.offlu.net) is a platform where member countries and scientists can share valuable information with the international veterinary and medical community. It is imperative that global health concerns and timely information sharing override lags in the scientific publications approval process, which may take from a few months to more that a year.

It is essential during outbreaks that pathogens, such as highly pathogenic avian influenza virus, be isolated from clinical cases and that any changes in the character of the virus be monitored to ensure that vaccine manufacturers are producing vaccines complying with OIE standards which are effective against virus strains in circulation, said Dr Domenech.

Should the changes be significant enough to warrant reformulation of the vaccine, FAO and the OIE say it would be in the best interest of global health for this to be done by national governments and commercial vaccine companies.

Scientists from such institutes as Istituto Zooprofilatico Sperimentale (Italy), Veterinary Laboratories Agency (UK), Southeastern Poultry Research Laboratory (USA), Australian Animal Health Laboratory, and Friedrich Loeffler Institute (Germany) have voiced their support for the FAO and OIE position that vaccine delivery alone is insufficient to halt virus circulation and to protect animal or human health.

?In an area where poultry populations have been vaccinated, well-planned serological studies must be conducted with full disclosure of the modalities of vaccination use in the poultry population, including the use of the cold chain and types of vaccines and date of last vaccination so results can be clearly interpreted,? Dr Vallat said.

.
 
Re: H5N1 bird flu virus is changing

of course, it is changing. But how much ?
Seems that the rate of changing is decreasing since 2005.
One strain becoming dominant would also indicate
fewer changing than before. So, what's the message ?
 
Re: H5N1 bird flu virus is changing

gsgs said:
of course, it is changing. But how much ?
Seems that the rate of changing is decreasing since 2005.
One strain becoming dominant would also indicate
fewer changing than before. So, what's the message ?

The changes in China are quite dramatic. 2006 sequence released today as number of chnages in receptor binding domain and HA cleavage site continue to RAPIDLY evolve.
 
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Re: H5N1 bird flu virus is changing

niman said:
The chnages in China are quite dramatic. 2006 sequence released today as number of chnages in receptor binding domain and HA cleavage site continue to RAPIDLY evolve.


Please tell us more details.
 
Re: H5N1 bird flu virus is changing

Solarpanel said:
Please tell us more details.
I am putting together a commentary, but the new sequences from northern China has changes have R220K and K222E as well as FOUR changes surrounding position 190 (A188E, A189T, T192I, L194I). Moreover there is some regions of identity with two newly released Hunan isolates, which have two of the above changes near 190 (T192I and T194I), but also has D187N and A189E).

Thus, there are three versions of 189 A, I, T as well as three versions of 227 S, N, R in addition to changes at 192, 194, 220, 222, 223.

H5N1 is recombining at a rapid rate at positions in or near the receptor binding domain.
 
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Re: H5N1 bird flu virus is changing

Has anyone reviewed and discussed the fact that A/Zhejiang/16/2006 has a "T129I" change in the PA segment?

This polymorphism is in all known pandemic influenza viruses and has a very human-like trait that continues today in our seasonal flu bugs.:(
 
Re: H5N1 bird flu virus is changing

mambird, do you have any educational info on the polymorphism you just mentioned? I dont recall hearing of this one before, and would like to know more about it.

Thanks!
 
Re: H5N1 bird flu virus is changing

The changes in China are quite dramatic. 2006 sequence released today as number of chnages in receptor binding domain and HA cleavage site continue to RAPIDLY evolve.
Hey Doc., how many of the six chambers in the Russian roulet gun are loaded?
 
Re: H5N1 bird flu virus is changing

Sounds like there are literally billions of guns, and the trend is towards more chambers loading bigger and bigger bullets.

Gnosis said:
Hey Doc., how many of the six chambers in the Russian roulet gun are loaded?
 
Re: H5N1 bird flu virus is changing

mambird, do you have any educational info on the polymorphism you just mentioned?

Sorry, don't have any scientific research references that I can provide at the moment. Thought maybe someone at this forum had already addressed the issue and could bring us up to date on the significance, if any.

All I can say is that the Threonine at position 129 of the PA segment is typically found only in avian isloates, while the Isoleucine is typically only in human ones, and has been in all pandemic viruses this last century. So, it seems that this particular Fujian virus may be beginning to take on human characteristics. Could be a signal.
 
Re: H5N1 bird flu virus is changing

4-ABBA said:
Sounds like there are literally billions of guns, and the trend is towards more chambers loading bigger and bigger bullets.

I think it's time to find a new analogy.
 
Re: H5N1 bird flu virus is changing

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Weekly US Map: Influenza Summary Update

Week ending November 4, 2006-Week 44
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Re: H5N1 bird flu virus is changing

Chiro said:
Here is the CDC link showing seasonal flu outbreaks by state. NC is the only state in the US that shows "regional".

http://www.cdc.gov/flu/weekly/usmap.htm

I live here in the Raleigh area :eek:. Feed back would be good from anyone!!
:confused: Thank you

There are school closings in NC and I would assume it is due to Influenza B, since two students were positive.
 
Re: H5N1 bird flu virus is changing

Chiro said:
Here is the CDC link showing seasonal flu outbreaks by state. NC is the only state in the US that shows "regional".

http://www.cdc.gov/flu/weekly/usmap.htm

I live here in the Raleigh area :eek:. Feed back would be good from anyone!!
:confused: Thank you
Feedback: Thanks for the update. Please continue to communicate until your power goes out or you are too ill to type. Thx again. Bye bye.:smartass:
 
Re: H5N1 bird flu virus is changing

I guess I'm just too dense to figure this one out, but what does H5N1 changing have to do with seasonal flu in North Carolina?
 
Re: H5N1 bird flu virus is changing

Mamabird said:
I guess I'm just too dense to figure this one out, but what does H5N1 changing have to do with seasonal flu in North Carolina?
I don't think H5N1 is related to Influenza B outbreak in NC, but H5N1 polymorphisms are beginning to show up in H1N1 seasonal flu.
 
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