tetano
Editor, Senior Moderator
Epidemiol Infect. 2014 Jun 30:1-9. [Epub ahead of print]
H3N2 canine influenza virus with the matrix gene from the pandemic A/H1N1 virus: infection dynamics in dogs and ferrets.
Moon H1, Hong M2, Kim JK3, Seon B1, Na W2, Park SJ2, An DJ4, Jeoung HY4, Kim DJ2, Kim JM1, Kim SH2, Webby RJ5, Webster RG5, Kang BK1, Song D2.
Author information
Abstract
SUMMARY After an outbreak of pandemic influenza A/H1N1 (pH1N1) virus, we had previously reported the emergence of a recombinant canine influenza virus (CIV) between the pH1N1 virus and the classic H3N2 CIV. Our ongoing routine surveillance isolated another reassortant H3N2 CIV carrying the matrix gene of the pH1N1 virus from 2012. The infection dynamics of this H3N2 CIV variant (CIV/H3N2mv) were investigated in dogs and ferrets via experimental infection and transmission. The CIV/H3N2mv-infected dogs and ferrets produced typical symptoms of respiratory disease, virus shedding, seroconversion, and direct-contact transmissions. Although indirect exposure was not presented for ferrets, CIV/H3N2mv presented higher viral replication in MDCK cells and more efficient transmission was observed in ferrets compared to classic CIV H3N2. This study demonstrates the effect of reassortment of the M gene of pH1N1 in CIV H3N2.
PMID:
24977303
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24977303
H3N2 canine influenza virus with the matrix gene from the pandemic A/H1N1 virus: infection dynamics in dogs and ferrets.
Moon H1, Hong M2, Kim JK3, Seon B1, Na W2, Park SJ2, An DJ4, Jeoung HY4, Kim DJ2, Kim JM1, Kim SH2, Webby RJ5, Webster RG5, Kang BK1, Song D2.
Author information
Abstract
SUMMARY After an outbreak of pandemic influenza A/H1N1 (pH1N1) virus, we had previously reported the emergence of a recombinant canine influenza virus (CIV) between the pH1N1 virus and the classic H3N2 CIV. Our ongoing routine surveillance isolated another reassortant H3N2 CIV carrying the matrix gene of the pH1N1 virus from 2012. The infection dynamics of this H3N2 CIV variant (CIV/H3N2mv) were investigated in dogs and ferrets via experimental infection and transmission. The CIV/H3N2mv-infected dogs and ferrets produced typical symptoms of respiratory disease, virus shedding, seroconversion, and direct-contact transmissions. Although indirect exposure was not presented for ferrets, CIV/H3N2mv presented higher viral replication in MDCK cells and more efficient transmission was observed in ferrets compared to classic CIV H3N2. This study demonstrates the effect of reassortment of the M gene of pH1N1 in CIV H3N2.
PMID:
24977303
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24977303