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H1N1 in conjunctiva is possible

Re: H1N1 in conjunctiva is possible

hat tip Ironorehopper -

http://www.flutrackers.com/forum/showthread.php?p=339698


Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract.


<a class="url n" href="http://www.hubmed.org/search.cgi?q=Chan%20MC%20[AU]"><abbr class="fn" title="Michael C W Chan">Chan MC</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Chan%20RW%20[AU]"><abbr class="fn" title="Renee W Y Chan">Chan RW</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Yu%20WC%20[AU]"><abbr class="fn" title="Wendy C L Yu">Yu WC</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Ho%20CC%20[AU]"><abbr class="fn" title="Carol C C Ho">Ho CC</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Yuen%20KM%20[AU]"><abbr class="fn" title="Kit M Yuen">Yuen KM</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Fong%20JH%20[AU]"><abbr class="fn" title="Joanne H M Fong">Fong JH</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Tang%20LL%20[AU]"><abbr class="fn" title="Lynsia L S Tang">Tang LL</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Lai%20WW%20[AU]"><abbr class="fn" title="Wico W Lai">Lai WW</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Lo%20AC%20[AU]"><abbr class="fn" title="Amy C Y Lo">Lo AC</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Chui%20WH%20[AU]"><abbr class="fn" title="W H Chui">Chui WH</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Sihoe%20AD%20[AU]"><abbr class="fn" title="Alan D L Sihoe">Sihoe AD</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Kwong%20DL%20[AU]"><abbr class="fn" title="Dora L W Kwong">Kwong DL</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Wong%20DS%20[AU]"><abbr class="fn" title="David S H Wong">Wong DS</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Tsao%20GS%20[AU]"><abbr class="fn" title="George S W Tsao">Tsao GS</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Poon%20LL%20[AU]"><abbr class="fn" title="Leo L M Poon">Poon LL</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Guan%20Y%20[AU]"><abbr class="fn" title="Yi Guan">Guan Y</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Nicholls%20JM%20[AU]"><abbr class="fn" title="John M Nicholls">Nicholls JM</abbr>, <a class="url n" href="http://www.hubmed.org/search.cgi?q=Peiris%20JS%20[AU]"><abbr class="fn" title="Joseph S M Peiris">Peiris JS</abbr>
<a href="http://www.hubmed.org/search.cgi?q=1525-2191%20[ISSN]"><abbr class="title" title="The American journal of pathology">Am J Pathol</abbr>.<abbr class="date-published" title="2010-Apr"> 2010 Apr </abbr>; 176(4): <abbr class="uri" title="urn:issn/1525-2191"></abbr>1828-40

The novel pandemic influenza H1N1 (H1N1pdm) virus of swine origin causes mild disease but occasionally leads to acute respiratory distress syndrome and death. It is important to understand the pathogenesis of this new disease in humans. We compared the virus tropism and host-responses elicited by pandemic H1N1pdm and seasonal H1N1 influenza viruses in ex vivo cultures of human conjunctiva, nasopharynx, bronchus, and lung, as well as in vitro cultures of human nasopharyngeal, bronchial, and alveolar epithelial cells. We found comparable replication and host-responses in seasonal and pandemic H1N1 viruses. However, pandemic H1N1pdm virus differs from seasonal H1N1 influenza virus in its ability to replicate in human conjunctiva, suggesting subtle differences in its receptor-binding profile and highlighting the potential role of the conjunctiva as an additional route of infection with H1N1pdm. A greater viral replication competence in bronchial epithelium at 33 degrees C may also contribute to the slight increase in virulence of the pandemic influenza virus. In contrast with highly pathogenic influenza H5N1 virus, pandemic H1N1pdm does not differ from seasonal influenza virus in its intrinsic capacity for cytokine dysregulation. Collectively, these results suggest that pandemic H1N1pdm virus differs in modest but subtle ways from seasonal H1N1 virus in its intrinsic virulence for humans, which is in accord with the epidemiology of the pandemic to date. These findings are therefore relevant for understanding transmission and therapy.
 
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