tetano
Editor, Senior Moderator
J Neuroimmunol. 2019 Apr 17;332:167-175. doi: 10.1016/j.jneuroim.2019.04.009. [Epub ahead of print]
[h=1]H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls.[/h] Schinkelshoek MS[SUP]1[/SUP], Fronczek R[SUP]2[/SUP], Kooy-Winkelaar EMC[SUP]3[/SUP], Petersen J[SUP]4[/SUP], Reid HH[SUP]4[/SUP], van der Heide A[SUP]5[/SUP], Drijfhout JW[SUP]3[/SUP], Rossjohn J[SUP]6[/SUP], Lammers GJ[SUP]2[/SUP], Koning F[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.
Copyright ? 2019 The Authors. Published by Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Cross-reactivity; H1N1; Hypocretin; Narcolepsy; T cells
PMID: 31048269 DOI: 10.1016/j.jneuroim.2019.04.009
[h=1]H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls.[/h] Schinkelshoek MS[SUP]1[/SUP], Fronczek R[SUP]2[/SUP], Kooy-Winkelaar EMC[SUP]3[/SUP], Petersen J[SUP]4[/SUP], Reid HH[SUP]4[/SUP], van der Heide A[SUP]5[/SUP], Drijfhout JW[SUP]3[/SUP], Rossjohn J[SUP]6[/SUP], Lammers GJ[SUP]2[/SUP], Koning F[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.
Copyright ? 2019 The Authors. Published by Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Cross-reactivity; H1N1; Hypocretin; Narcolepsy; T cells
PMID: 31048269 DOI: 10.1016/j.jneuroim.2019.04.009