Tonka
Well-known member
http://eleconomista.com.mx/internacional/2010/09/15/gripe-h1n1-puede-convertirse-resistente
Spanish to English translation
H1N1 could become resistant
September 15, 2010 - 17:17
Washington.-A H1N1 influenza virus that infected a woman in Singapore has mutated into a form resistant to the drugs virtually overnight, medics said in a study that shows the limitations of the use of drugs to treat influenza .
Although the woman recovered, the mutation took place within 48 hours, which causes the infection is increasingly resistant to the effects of Tamiflu, the main drug used to fight the flu and is known generically as oseltamivir.
"Our data indicate that oseltamivir resistance developed in two days," wrote Masafumi Inoue and colleagues at the Agency for Science, Technology and Research in Singapore in the journal Emerging Infectious Diseases.
The H1N1 flu pandemic has ended, but the virus has joined the mix of seasonal flu germs.
A distant relative, also called H1N1, developed in 2008 a broad resistance to Tamiflu, and the medicine is useless against him. Tamiflu is manufactured and distributed by Roche and Gilead Sciences GILD.O. ROG.VX
Researchers know that the flu is highly prone to mutation and most of the strains have developed resistance to two older flu drugs, amantadine and rimantadine.
When H1N1 emerged in March 2009, doctors feared he would be worse than it was. In Singapore, patients were immediately treated with Tamiflu.
But doctors also feared that the virus could mutate and were tuned to detect a particular genetic mutation, called H275Y, which confers resistance to Tamiflu.
Virus samples from the patient in Singapore showed that the mutation was 48 hours after she started taking the drug, Inoue and colleagues said.
"Whatever the epidemiological data display, clinicians should consider the resistance when patients do not respond to treatment of the pandemic (H1N1) 2009, for H275Y may arise from day to day, as the case reminds us" they wrote.
Another flu drug that is licensed, Relenza, known generically as zanamivir and developed by GlaxoSmithKline and Biota. Just like Tamiflu, belongs to a class of medications called neuraminidase inhibitors.
BioCryst, a small laboratory, is developing a flu drug called peramivir.
BVC
Spanish to English translation
H1N1 could become resistant
September 15, 2010 - 17:17
Washington.-A H1N1 influenza virus that infected a woman in Singapore has mutated into a form resistant to the drugs virtually overnight, medics said in a study that shows the limitations of the use of drugs to treat influenza .
Although the woman recovered, the mutation took place within 48 hours, which causes the infection is increasingly resistant to the effects of Tamiflu, the main drug used to fight the flu and is known generically as oseltamivir.
"Our data indicate that oseltamivir resistance developed in two days," wrote Masafumi Inoue and colleagues at the Agency for Science, Technology and Research in Singapore in the journal Emerging Infectious Diseases.
The H1N1 flu pandemic has ended, but the virus has joined the mix of seasonal flu germs.
A distant relative, also called H1N1, developed in 2008 a broad resistance to Tamiflu, and the medicine is useless against him. Tamiflu is manufactured and distributed by Roche and Gilead Sciences GILD.O. ROG.VX
Researchers know that the flu is highly prone to mutation and most of the strains have developed resistance to two older flu drugs, amantadine and rimantadine.
When H1N1 emerged in March 2009, doctors feared he would be worse than it was. In Singapore, patients were immediately treated with Tamiflu.
But doctors also feared that the virus could mutate and were tuned to detect a particular genetic mutation, called H275Y, which confers resistance to Tamiflu.
Virus samples from the patient in Singapore showed that the mutation was 48 hours after she started taking the drug, Inoue and colleagues said.
"Whatever the epidemiological data display, clinicians should consider the resistance when patients do not respond to treatment of the pandemic (H1N1) 2009, for H275Y may arise from day to day, as the case reminds us" they wrote.
Another flu drug that is licensed, Relenza, known generically as zanamivir and developed by GlaxoSmithKline and Biota. Just like Tamiflu, belongs to a class of medications called neuraminidase inhibitors.
BioCryst, a small laboratory, is developing a flu drug called peramivir.
BVC