Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Published online before print August 29, 2011, doi: 10.1073/pnas.1102999108 PNAS September 20, 2011 vol. 108 no. 38 16050-16055
Javier A. Bravo,
Paul Forsythe,
Marianne V. Chew,
Emily Escaravage,
H?l?ne M. Savignac,
Timothy G. Dinan,
John Bienenstock,
and John F. Cryan
Abstract
There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS).
[snip]
Together, these findings highlight the important role of bacteria in the bidirectional communication of the gut?brain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.
Copyright ?2011 by the National Academy of Sciences
