tetano
Editor, Senior Moderator
Clin Infect Dis. 2014 Jan 9. [Epub ahead of print]
Guillain-Barre Syndrome, Influenza and Influenza Vaccination--the Epidemiologic Evidence.
Vellozzi C, Iqbal S, Broder K.
Author information
Abstract
Guillain-Barr? syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide, and thought to be immune-mediated. It is preceded by upper respiratory or gastrointestinal infection in about two-thirds of cases and associated with some viral infections, including influenza. GBS has also been associated with the 1976 swine-influenza vaccine. Thereafter, some studies have shown a small increased risk of GBS following seasonal and 2009 H1N1 monovalent influenza vaccines. Studies over the years have also shown an increased risk of GBS following influenza infection, and the magnitude of risk is several times greater than that following influenza vaccination. Since GBS is rare, and even rarer following vaccination, it is difficult to estimate precise risk. We try to shed light on the complex relationship of GBS and its association with influenza and influenza vaccines over the past 35 years.
PMID:
24415636
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24415636
Guillain-Barre Syndrome, Influenza and Influenza Vaccination--the Epidemiologic Evidence.
Vellozzi C, Iqbal S, Broder K.
Author information
Abstract
Guillain-Barr? syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide, and thought to be immune-mediated. It is preceded by upper respiratory or gastrointestinal infection in about two-thirds of cases and associated with some viral infections, including influenza. GBS has also been associated with the 1976 swine-influenza vaccine. Thereafter, some studies have shown a small increased risk of GBS following seasonal and 2009 H1N1 monovalent influenza vaccines. Studies over the years have also shown an increased risk of GBS following influenza infection, and the magnitude of risk is several times greater than that following influenza vaccination. Since GBS is rare, and even rarer following vaccination, it is difficult to estimate precise risk. We try to shed light on the complex relationship of GBS and its association with influenza and influenza vaccines over the past 35 years.
PMID:
24415636
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24415636