tetano
Editor, Senior Moderator
J Neurol Sci. 2011 Oct 12. [Epub ahead of print]
Guillain-Barr? syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: Case report and review of the literature.
Cortese A, Baldanti F, Tavazzi E, Carnevale L, Minoli L, Lozza A, Marchioni E.
Source
Unit of General Neurology, Institute of Neurology Fondazione IRCCS "C.Mondino", Pavia, Italy.
Abstract
Guillain-Barr? syndrome (GBS) is an acute immune-mediated disorder of the peripheral nervous system and a triggering infectious event is often reported in the weeks before the disease onset. Influenza viruses have been associated with Guillain-Barr? syndrome (GBS), both after infection and, in rare cases, after vaccination. However, GBS has rarely reported to be a neurological complication of the recent pandemic influenza A(H1N1) 2009 virus infections. Here we describe the case of a young man, who developed acute severe motor inflammatory demyelinating polyradiculoneuropathy during influenza A(H1N1)2009 infection. Peculiar features are the findings of a mutated haemagglutinin gene (D222E variant), which has never previously been associated with neurological involvement, and the almost simultaneous appearance of respiratory infectious and immune-mediated neurological symptoms. Moreover we review the clinical presentation, laboratory findings and outcome of influenza-related GBS.
Copyright ? 2011 Elsevier B.V. All rights reserved.
PMID:
22000408
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22000408
Guillain-Barr? syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: Case report and review of the literature.
Cortese A, Baldanti F, Tavazzi E, Carnevale L, Minoli L, Lozza A, Marchioni E.
Source
Unit of General Neurology, Institute of Neurology Fondazione IRCCS "C.Mondino", Pavia, Italy.
Abstract
Guillain-Barr? syndrome (GBS) is an acute immune-mediated disorder of the peripheral nervous system and a triggering infectious event is often reported in the weeks before the disease onset. Influenza viruses have been associated with Guillain-Barr? syndrome (GBS), both after infection and, in rare cases, after vaccination. However, GBS has rarely reported to be a neurological complication of the recent pandemic influenza A(H1N1) 2009 virus infections. Here we describe the case of a young man, who developed acute severe motor inflammatory demyelinating polyradiculoneuropathy during influenza A(H1N1)2009 infection. Peculiar features are the findings of a mutated haemagglutinin gene (D222E variant), which has never previously been associated with neurological involvement, and the almost simultaneous appearance of respiratory infectious and immune-mediated neurological symptoms. Moreover we review the clinical presentation, laboratory findings and outcome of influenza-related GBS.
Copyright ? 2011 Elsevier B.V. All rights reserved.
PMID:
22000408
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22000408