Mary Wilson
Well-known member
Published:June 21, 2022
DOI:https://doi.org/10.1016/S0140-6736(22)01063-7
Pradip Dashraath, Karin Nielsen-Saines, Citra Mattar, Didier Musso, Paul Tambyah, David Baud
On May 21, 2022, WHO reported an emerging global outbreak of monkeypox virus infection, with documented community transmission among people in contact with symptomatic cases in non-endemic countries.
The likelihood of infection in pregnant women is high because of post-COVID-19 border reopening and travel among countries presently experiencing an outbreak.
Human infections with monkeypox and smallpox (a closely related orthopoxvirus) can carry a high risk of severe congenital infection, pregnancy loss, and maternal morbi- dity and mortality.1 Of four pregnant women from the Democratic Repub- lic of the Congo infected with monkeypox virus (probably with the central African clade of the virus) between 2007 and 2011, two had spontaneous early miscarriages, and one had a second-trimester loss at 18 weeks’ gestation.2 The stillborn fetus had a generalised skin rash, and monkeypox virus DNA detected in fetal tissue, umbilical cord, and placenta, confirming vertical transmission of monkeypox virus. Genomic sequencing data suggest the west African clade of monkeypox virus is responsible for the current outbreak; although it is associated with milder disease and a lower case fatality rate in non- pregnant people, the e ects of this clade in pregnancy are unknown.
https://www.thelancet.com/action/showPdf?pii=S0140-6736(22)01063-7
DOI:https://doi.org/10.1016/S0140-6736(22)01063-7
Pradip Dashraath, Karin Nielsen-Saines, Citra Mattar, Didier Musso, Paul Tambyah, David Baud
On May 21, 2022, WHO reported an emerging global outbreak of monkeypox virus infection, with documented community transmission among people in contact with symptomatic cases in non-endemic countries.
The likelihood of infection in pregnant women is high because of post-COVID-19 border reopening and travel among countries presently experiencing an outbreak.
Human infections with monkeypox and smallpox (a closely related orthopoxvirus) can carry a high risk of severe congenital infection, pregnancy loss, and maternal morbi- dity and mortality.1 Of four pregnant women from the Democratic Repub- lic of the Congo infected with monkeypox virus (probably with the central African clade of the virus) between 2007 and 2011, two had spontaneous early miscarriages, and one had a second-trimester loss at 18 weeks’ gestation.2 The stillborn fetus had a generalised skin rash, and monkeypox virus DNA detected in fetal tissue, umbilical cord, and placenta, confirming vertical transmission of monkeypox virus. Genomic sequencing data suggest the west African clade of monkeypox virus is responsible for the current outbreak; although it is associated with milder disease and a lower case fatality rate in non- pregnant people, the e ects of this clade in pregnancy are unknown.
https://www.thelancet.com/action/showPdf?pii=S0140-6736(22)01063-7