tetano
Editor, Senior Moderator
Ann Transl Med. 2015 Feb;3(2):22. doi: 10.3978/j.issn.2305-5839.2015.01.08.
[h=1]Glucan supplementation enhances the immune response against an influenza challenge in mice.[/h] Vetvicka V[SUP]1[/SUP], Vetvickova J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The strong immunostimulating potential of β-glucans has been well established in numerous diseases. However, the effects on viral infection were less studied.
[h=4]METHODS:[/h] In our study, we focused on possible effects of a special combined glucan formulation on immunosuppression caused by influenza infection.
[h=4]RESULTS:[/h] We found that a 2-week oral feeding with glucan mixture significantly reduced the effects of influenza infection in total mortality. Our study was focused on phagocytosis, cytokine levels, antibody response and cytotoxicity assay.
[h=4]CONCLUSIONS:[/h] Based on our data, we concluded that these effects are caused by stimulation of both cellular and humoral immune reaction resulting in lower viral load.
[h=4]KEYWORDS:[/h] Glucan; immune system; influenza; virus
PMID: 25738142 [PubMed] Free PMC Article
[h=1]Glucan supplementation enhances the immune response against an influenza challenge in mice.[/h] Vetvicka V[SUP]1[/SUP], Vetvickova J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The strong immunostimulating potential of β-glucans has been well established in numerous diseases. However, the effects on viral infection were less studied.
[h=4]METHODS:[/h] In our study, we focused on possible effects of a special combined glucan formulation on immunosuppression caused by influenza infection.
[h=4]RESULTS:[/h] We found that a 2-week oral feeding with glucan mixture significantly reduced the effects of influenza infection in total mortality. Our study was focused on phagocytosis, cytokine levels, antibody response and cytotoxicity assay.
[h=4]CONCLUSIONS:[/h] Based on our data, we concluded that these effects are caused by stimulation of both cellular and humoral immune reaction resulting in lower viral load.
[h=4]KEYWORDS:[/h] Glucan; immune system; influenza; virus
PMID: 25738142 [PubMed] Free PMC Article