sharon sanders
Editor-in-Chief & President
Ozone Modifies Associations between Temperature and Cardiovascular Mortality ? analysis of the NMMAPS data
<nobr>Cizao Ren <sup>1</sup><sup>*</sup>,</nobr> <nobr>Gail M Williams <sup>2</sup>,</nobr> <nobr>Lidia Morawska <sup>3</sup>,</nobr> <nobr>Kerrie Mengersen <sup>4</sup></nobr> and <nobr>Shilu Tong <sup>1</sup></nobr>
[SIZE=-1] <sup>1</sup> School of Public Health, IHBI, Queensland University of Technology, Australia
<sup>2</sup> School of Population Health, University of Queensland, Australia
<sup>3</sup> School of Chemical and Physical Sceinces, Queensland University of Technology, Australia
<sup>4</sup> School of Mathematical Sciences, Queensland University of Technology, Australia
[/SIZE]
[SIZE=-1] <sup>*</sup> To whom correspondence should be addressed. E-mail: rencizao@yahoo.com<script type="text/javascript"><!-- var u = "rencizao", d = "yahoo.com"; document.getElementById("em0").innerHTML = '<a href="mailto:' + u + '@' + d + '">' + u + '@' + d + '<\/a>'//--></script>. [/SIZE]
[SIZE=-1]Accepted 14 September 2007[/SIZE]
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<table bgcolor="#e1e1e1" cellpadding="0" cellspacing="0" width="100%"> <tbody><tr><td align="left" bgcolor="#ffffff" valign="middle" width="5%">
</td> <th align="left" valign="middle" width="95%">[SIZE=+2] Abstract[/SIZE]</th></tr></tbody></table>
Objectives: Both ambient ozone and temperature are associated<sup> </sup>with human health. However, few data are available on whether<sup> </sup>ozone modifies temperature effects.. This study aims to explore<sup> </sup>whether ozone modified associations between maximum temperature<sup> </sup>and cardiovascular mortality in the United States. Methods:<sup> </sup> We obtained data from the US National Morbidity, Mortality,<sup> </sup>and Air Pollution Study (NMMAPS) website. We used two time-series<sup> </sup>Poisson regression models (a response surface model and a stratification<sup> </sup>model) to examine whether ozone modified associations between<sup> </sup>maximum temperature and cardiovascular mortality (CVM) in 95<sup> </sup>large US communities during 1987-2000 in summer (June to September).<sup> </sup>We used Bayesian meta-analysis to pool estimates in each community. Results:<sup> </sup> The response surface model was used to examine the joint effects<sup> </sup>of temperature and ozone on CVM in summer.
Results indicate<sup> </sup>that ozone positively modified the temperature-CVM associations<sup> </sup>across the different regions. The stratification model quantified<sup> </sup>the temperature-CVM associations across different levels of<sup> </sup>ozone. Results show that in general the higher the ozone concentration,<sup> </sup>the stronger the temperature-CVM associations across the communities.
<sup>
</sup>
<sup> </sup>A10?C increase in temperature on the same day was associated<sup> </sup>with an increase in CVM by 1.17 % and 8.31% for the lowest and<sup> </sup>highest level of ozone concentrations in all communities, respectively. Conclusion:<sup> </sup> Ozone modified temperature effects in the different regions<sup> </sup>in the United States. It is important to evaluate the modifying<sup> </sup>role of ozone when estimating temperature-related health impacts<sup> </sup>and to further investigate the reasons behind the regional variability<sup> </sup>and mechanism for the interaction between temperature and ozone.
http://oem.bmj.com/cgi/content/abstract/oem.2007.033878v2
<nobr>Cizao Ren <sup>1</sup><sup>*</sup>,</nobr> <nobr>Gail M Williams <sup>2</sup>,</nobr> <nobr>Lidia Morawska <sup>3</sup>,</nobr> <nobr>Kerrie Mengersen <sup>4</sup></nobr> and <nobr>Shilu Tong <sup>1</sup></nobr>
[SIZE=-1] <sup>1</sup> School of Public Health, IHBI, Queensland University of Technology, Australia
<sup>2</sup> School of Population Health, University of Queensland, Australia
<sup>3</sup> School of Chemical and Physical Sceinces, Queensland University of Technology, Australia
<sup>4</sup> School of Mathematical Sciences, Queensland University of Technology, Australia
[/SIZE]
[SIZE=-1] <sup>*</sup> To whom correspondence should be addressed. E-mail: rencizao@yahoo.com<script type="text/javascript"><!-- var u = "rencizao", d = "yahoo.com"; document.getElementById("em0").innerHTML = '<a href="mailto:' + u + '@' + d + '">' + u + '@' + d + '<\/a>'//--></script>. [/SIZE]
[SIZE=-1]Accepted 14 September 2007[/SIZE]
<!-- null -->
<table bgcolor="#e1e1e1" cellpadding="0" cellspacing="0" width="100%"> <tbody><tr><td align="left" bgcolor="#ffffff" valign="middle" width="5%">
Objectives: Both ambient ozone and temperature are associated<sup> </sup>with human health. However, few data are available on whether<sup> </sup>ozone modifies temperature effects.. This study aims to explore<sup> </sup>whether ozone modified associations between maximum temperature<sup> </sup>and cardiovascular mortality in the United States. Methods:<sup> </sup> We obtained data from the US National Morbidity, Mortality,<sup> </sup>and Air Pollution Study (NMMAPS) website. We used two time-series<sup> </sup>Poisson regression models (a response surface model and a stratification<sup> </sup>model) to examine whether ozone modified associations between<sup> </sup>maximum temperature and cardiovascular mortality (CVM) in 95<sup> </sup>large US communities during 1987-2000 in summer (June to September).<sup> </sup>We used Bayesian meta-analysis to pool estimates in each community. Results:<sup> </sup> The response surface model was used to examine the joint effects<sup> </sup>of temperature and ozone on CVM in summer.
Results indicate<sup> </sup>that ozone positively modified the temperature-CVM associations<sup> </sup>across the different regions. The stratification model quantified<sup> </sup>the temperature-CVM associations across different levels of<sup> </sup>ozone. Results show that in general the higher the ozone concentration,<sup> </sup>the stronger the temperature-CVM associations across the communities.
<sup>
</sup>
<sup> </sup>A10?C increase in temperature on the same day was associated<sup> </sup>with an increase in CVM by 1.17 % and 8.31% for the lowest and<sup> </sup>highest level of ozone concentrations in all communities, respectively. Conclusion:<sup> </sup> Ozone modified temperature effects in the different regions<sup> </sup>in the United States. It is important to evaluate the modifying<sup> </sup>role of ozone when estimating temperature-related health impacts<sup> </sup>and to further investigate the reasons behind the regional variability<sup> </sup>and mechanism for the interaction between temperature and ozone.
http://oem.bmj.com/cgi/content/abstract/oem.2007.033878v2