tetano
Editor, Senior Moderator
Glob Health Med
. 2020 Jun 30;2(3):174-177.
doi: 10.35772/ghm.2020.01054.
COVID-19 can suddenly become severe: a case series from Tokyo, Japan
Keiji Nakamura[SUP] 1 [/SUP], Satoshi Ide[SUP] 1 [/SUP], Sho Saito[SUP] 1 [/SUP], Noriko Kinoshita[SUP] 1 [/SUP], Satoshi Kutsuna[SUP] 1 [/SUP], Yuki Moriyama[SUP] 1 [/SUP], Tetsuya Suzuki[SUP] 1 [/SUP], Masayuki Ota[SUP] 1 [/SUP], Hidetoshi Nomoto[SUP] 1 [/SUP], Tetsuya Mizoue[SUP] 2 [/SUP], Masayuki Hojo[SUP] 3 [/SUP], Jin Takasaki[SUP] 3 [/SUP], Yusuke Asai[SUP] 4 [/SUP], Mari Terada[SUP] 1 [/SUP], Yutaro Akiyama[SUP] 1 [/SUP], Yusuke Miyazato[SUP] 1 [/SUP], Takato Nakamoto[SUP] 1 [/SUP], Yuji Wakimoto[SUP] 1 [/SUP], Mugen Ujiie[SUP] 1 [/SUP], Kei Yamamoto[SUP] 1 [/SUP], Masahiro Ishikane[SUP] 1 [/SUP], Shinichiro Morioka[SUP] 1 [/SUP], Kayoko Hayakawa[SUP] 1 [/SUP], Haruhito Sugiyama[SUP] 5 [/SUP], Norio Ohmagari[SUP] 1 [/SUP]
Affiliations
Abstract
Since the initial report of coronavirus disease (COVID-19) from the City of Wuhan, China in December 2019, there have been multiple cases globally. Reported here are 11 cases of COVID-19 at this hospital; all of the patients in question presented with relative bradycardia. The severity of the disease was classified into four grades. Of the patients studied, 3 with mild COVID-19 and 3 with moderate COVID-19 improved spontaneously. Lopinavir/ ritonavir was administered to 3 patients with severe COVID-19 and 2 with critical COVID-19. Both patients with critical COVID-19 required mechanical ventilation and extracorporeal membrane oxygenation. Both patients with critical COVID-19 had a higher fever that persisted for longer than patients with milder COVID-19. The respiratory status of patients with critical COVID-19 worsened rapidly 7 days after the onset of symptoms. Relative bradycardia may be useful in distinguishing between COVID-19 and bacterial community-acquired pneumonia. In patients who have had a fever for > 7 days, the condition might worsen suddenly.
Keywords: COVID-19; SARS-CoV-2; pneumonia.
. 2020 Jun 30;2(3):174-177.
doi: 10.35772/ghm.2020.01054.
COVID-19 can suddenly become severe: a case series from Tokyo, Japan
Keiji Nakamura[SUP] 1 [/SUP], Satoshi Ide[SUP] 1 [/SUP], Sho Saito[SUP] 1 [/SUP], Noriko Kinoshita[SUP] 1 [/SUP], Satoshi Kutsuna[SUP] 1 [/SUP], Yuki Moriyama[SUP] 1 [/SUP], Tetsuya Suzuki[SUP] 1 [/SUP], Masayuki Ota[SUP] 1 [/SUP], Hidetoshi Nomoto[SUP] 1 [/SUP], Tetsuya Mizoue[SUP] 2 [/SUP], Masayuki Hojo[SUP] 3 [/SUP], Jin Takasaki[SUP] 3 [/SUP], Yusuke Asai[SUP] 4 [/SUP], Mari Terada[SUP] 1 [/SUP], Yutaro Akiyama[SUP] 1 [/SUP], Yusuke Miyazato[SUP] 1 [/SUP], Takato Nakamoto[SUP] 1 [/SUP], Yuji Wakimoto[SUP] 1 [/SUP], Mugen Ujiie[SUP] 1 [/SUP], Kei Yamamoto[SUP] 1 [/SUP], Masahiro Ishikane[SUP] 1 [/SUP], Shinichiro Morioka[SUP] 1 [/SUP], Kayoko Hayakawa[SUP] 1 [/SUP], Haruhito Sugiyama[SUP] 5 [/SUP], Norio Ohmagari[SUP] 1 [/SUP]
Affiliations
- PMID: 33330803
- PMCID: PMC7731267
- DOI: 10.35772/ghm.2020.01054
Abstract
Since the initial report of coronavirus disease (COVID-19) from the City of Wuhan, China in December 2019, there have been multiple cases globally. Reported here are 11 cases of COVID-19 at this hospital; all of the patients in question presented with relative bradycardia. The severity of the disease was classified into four grades. Of the patients studied, 3 with mild COVID-19 and 3 with moderate COVID-19 improved spontaneously. Lopinavir/ ritonavir was administered to 3 patients with severe COVID-19 and 2 with critical COVID-19. Both patients with critical COVID-19 required mechanical ventilation and extracorporeal membrane oxygenation. Both patients with critical COVID-19 had a higher fever that persisted for longer than patients with milder COVID-19. The respiratory status of patients with critical COVID-19 worsened rapidly 7 days after the onset of symptoms. Relative bradycardia may be useful in distinguishing between COVID-19 and bacterial community-acquired pneumonia. In patients who have had a fever for > 7 days, the condition might worsen suddenly.
Keywords: COVID-19; SARS-CoV-2; pneumonia.