tetano
Editor, Senior Moderator
Geroscience
. 2020 Jul 17.
doi: 10.1007/s11357-020-00226-9. Online ahead of print.
Novel coronavirus epidemic in the Hungarian population, a cross-sectional nationwide survey to support the exit policy in Hungary
B?la Merkely[SUP] 1 [/SUP], Attila J Szab?[SUP] 2 [/SUP], Annam?ria Kosztin[SUP] 3 [/SUP], Ervin Ber?nyi[SUP] 4 [/SUP], Andor Sebesty?n[SUP] 5 [/SUP], Csaba Lengyel[SUP] 6 [/SUP], Gergő Merkely[SUP] 7 8 [/SUP], J?lia Kar?dy[SUP] 3 9 [/SUP], Istv?n V?rkonyi[SUP] 10 [/SUP], Csaba Papp[SUP] 4 [/SUP], Attila Miseta[SUP] 11 [/SUP], J?zsef Betlehem[SUP] 12 [/SUP], Katalin Buri?n[SUP] 13 [/SUP], Ildik? Cs?ka[SUP] 14 [/SUP], Barna V?s?rhelyi[SUP] 15 [/SUP], Endre Ludwig[SUP] 16 17 [/SUP], Gyula Prinz[SUP] 16 [/SUP], J?nos Sink?[SUP] 16 17 [/SUP], Bal?zs Hank?[SUP] 18 [/SUP], P?ter Varga[SUP] 7 [/SUP], G?bor ?ron F?l?p[SUP] 3 [/SUP], Korn?lia Mag[SUP] 19 [/SUP], Zolt?n Vok?[SUP] 20 [/SUP], HUNgarian COronaVirus-19 Epidemiological Research (H-UNCOVER) investigators
Affiliations
Abstract
After months of restrictive containment efforts to fight the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic, European countries are planning to reopen. To support the process, we conducted a cross-sectional survey among the Hungarian population to estimate the prevalence of infectious cases and prior SARS-CoV-2 exposure. A representative sample (n = 17,787) for the Hungarian population of 14 years or older living in private households (n = 8,283,810) was selected. The study was performed within 16 days after 50 days of restrictions, when the number of confirmed cases was stable low. Naso- and oropharyngeal smears and blood samples were collected for PCR and antibody testing. The testing was accompanied by a questionnaire about symptoms, comorbidities, and contacts. Design-based prevalence estimates were calculated. In total, 10,474 individuals (67.7% taken into account a sample frame error of 2315) of the selected sample participated in the survey. Of the tested individuals, 3 had positive PCR and 69 had positive serological test. Population estimate of the number of SARS-CoV-2 infection and seropositivity were 2421 and 56,439, respectively, thus active infection rate (2.9/10,000) and the prevalence of prior SARS-CoV-2 exposure (68/10,000) was low. Self-reported loss of smell or taste and body aches were significantly more frequent among those with SARS-CoV-2. In this representative, cross-sectional survey of the Hungarian population with a high participation rate, the overall active infection rate was low in sync with the prevalence of prior SARS-CoV-2 exposure. We demonstrated a potential success of containment efforts, supporting an exit strategy. NCT04370067, 30.04.2020.
Keywords: COVID-19; Cross-sectional; Hungary; Nationwide; SARS-CoV-2.
. 2020 Jul 17.
doi: 10.1007/s11357-020-00226-9. Online ahead of print.
Novel coronavirus epidemic in the Hungarian population, a cross-sectional nationwide survey to support the exit policy in Hungary
B?la Merkely[SUP] 1 [/SUP], Attila J Szab?[SUP] 2 [/SUP], Annam?ria Kosztin[SUP] 3 [/SUP], Ervin Ber?nyi[SUP] 4 [/SUP], Andor Sebesty?n[SUP] 5 [/SUP], Csaba Lengyel[SUP] 6 [/SUP], Gergő Merkely[SUP] 7 8 [/SUP], J?lia Kar?dy[SUP] 3 9 [/SUP], Istv?n V?rkonyi[SUP] 10 [/SUP], Csaba Papp[SUP] 4 [/SUP], Attila Miseta[SUP] 11 [/SUP], J?zsef Betlehem[SUP] 12 [/SUP], Katalin Buri?n[SUP] 13 [/SUP], Ildik? Cs?ka[SUP] 14 [/SUP], Barna V?s?rhelyi[SUP] 15 [/SUP], Endre Ludwig[SUP] 16 17 [/SUP], Gyula Prinz[SUP] 16 [/SUP], J?nos Sink?[SUP] 16 17 [/SUP], Bal?zs Hank?[SUP] 18 [/SUP], P?ter Varga[SUP] 7 [/SUP], G?bor ?ron F?l?p[SUP] 3 [/SUP], Korn?lia Mag[SUP] 19 [/SUP], Zolt?n Vok?[SUP] 20 [/SUP], HUNgarian COronaVirus-19 Epidemiological Research (H-UNCOVER) investigators
Affiliations
- PMID: 32677025
- DOI: 10.1007/s11357-020-00226-9
Abstract
After months of restrictive containment efforts to fight the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic, European countries are planning to reopen. To support the process, we conducted a cross-sectional survey among the Hungarian population to estimate the prevalence of infectious cases and prior SARS-CoV-2 exposure. A representative sample (n = 17,787) for the Hungarian population of 14 years or older living in private households (n = 8,283,810) was selected. The study was performed within 16 days after 50 days of restrictions, when the number of confirmed cases was stable low. Naso- and oropharyngeal smears and blood samples were collected for PCR and antibody testing. The testing was accompanied by a questionnaire about symptoms, comorbidities, and contacts. Design-based prevalence estimates were calculated. In total, 10,474 individuals (67.7% taken into account a sample frame error of 2315) of the selected sample participated in the survey. Of the tested individuals, 3 had positive PCR and 69 had positive serological test. Population estimate of the number of SARS-CoV-2 infection and seropositivity were 2421 and 56,439, respectively, thus active infection rate (2.9/10,000) and the prevalence of prior SARS-CoV-2 exposure (68/10,000) was low. Self-reported loss of smell or taste and body aches were significantly more frequent among those with SARS-CoV-2. In this representative, cross-sectional survey of the Hungarian population with a high participation rate, the overall active infection rate was low in sync with the prevalence of prior SARS-CoV-2 exposure. We demonstrated a potential success of containment efforts, supporting an exit strategy. NCT04370067, 30.04.2020.
Keywords: COVID-19; Cross-sectional; Hungary; Nationwide; SARS-CoV-2.