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Germany - First case of West Nile virus infection in a horse detected

Gert van der Hoek

In Memoriam - Editor, Senior Moderator
09/24/2018

On 21.09.18 the first case of a West Nile virus infection in a horse was found in Germany. Evidence was provided by the National Reference Laboratory for West Nile Virus Infections (WNV) in FLI bird and horse. The dead animal comes from the district of Elbe-Elster (Brandenburg).

Horses, like humans and birds, can be infected by virus-borne bloodsucking mosquitoes. The horse is considered as the human but as a so-called "dead end host", i. the virus does not multiply to the extent that it is sufficient for the further infection of mosquitoes. WNV-infected and diseased horses are therefore not at risk of infection.

The majority of WNV-infected horses, similar to humans, develop no clinical symptoms. However, some animals respond with significant CNS deficits due to meningitis or encephalitis caused by WNV. Febrile diseases are rare. Central nervous disorders include stumbling, post paralysis, ataxia, generalized weakness, tremor, and paralysis until it becomes lodged. Although clinically ill horses can survive the infection, they suffer lifelong failure (neurological damage) in up to 20 percent of cases. In 22-44% of clinically ill horses, the disease can be fatal.

There is no specific therapy for WNV infection, only symptomatic treatment is possible. As a preventive measure, three vaccines for use on horses are available in Germany, which are approved by the European Medicines Agency (EMA). These include an inactivated whole virus vaccine as well as a recombinant live or a recombinant dead vaccine.


In Europe, WNV first appeared in France in the early 1960s and has since established itself throughout the Mediterranean. WNV infections in humans and horses occur regularly, mainly from southern and southern European countries (France, Italy, Croatia, Albania, Greece, Turkey, Austria, Hungary, Serbia, Spain, the Czech Republic).

Due to the epidemiological situation, the occurrence of WNV in Germany is not surprising. So far, a hawk from Bad D?ben (Saxony), two bearded owls from Poing (Bavaria), a bearded owl from Halle and a hawk from Bernburg (both Saxony-Anhalt) as well as two snowy owls and a blackbird from Berlin have tested positive for WNV. Long-lasting high temperatures favor the virus multiplication in the mosquito. Therefore, other cases of WNV in birds and horses are not excluded.


285px-Locator_map_Brandenburg_in_Germany.svg.png

Brandenburg State - wikipedia
 
[TABLE="class: TableChoisir, border: 0, cellpadding: 0, cellspacing: 0"]
[TR]
[TD]

[TD="width: *, align: left"] West Nile Fever,
Germany

[/TD]
[TD="width: 1%, align: right"] [/TD]
[/TD]
[/TR]
[TR]
[TD] [TABLE="class: TableChoisir, border: 0, cellpadding: 0, cellspacing: 0"]
[TR]
[TD="class: topbigtabletitle27"]Information received on 25/09/2018 from Dr. Karin Schwabenbauer, Ministerial Dirigentin and Chief Veterinary Officer , Directorate of Animal Health, Animal Welfare, Bundesministerium f?r Ern?hrung und Landwirtschaft (BMEL) , Bonn, Germany[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] Summary
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th, width: 10%"]Report type[/TD]
[TD="width: 30%"]Immediate notification[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Date of start of the event[/TD]
[TD="width: 30%"]21/09/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Date of confirmation of the event[/TD]
[TD="width: 30%"]24/09/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Report date[/TD]
[TD="width: 30%"]25/09/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Date submitted to OIE[/TD]
[TD="width: 30%"]25/09/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Reason for notification[/TD]
[TD="width: 30%"]First occurrence of a listed disease[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Manifestation of disease[/TD]
[TD="width: 30%"]Clinical disease[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Causal agent[/TD]
[TD="width: 30%"]West Nile virus[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Nature of diagnosis[/TD]
[TD="width: 30%"]Laboratory (basic), Laboratory (advanced)[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]This event pertains to[/TD]
[TD="width: 30%"]a defined zone within the country[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] New outbreaks (1)
[TABLE="class: TableFoyers, width: 918"]
[/TABLE]

[/TD]
[/TR]
[TR]
[TD] [TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left, align: left"]Outbreak 1 (18-416-00008)[/TD]
[TD="class: filtrer_th ta_left"]Plessa, Elbe-Elster, Brandenburg[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Date of start of the outbreak[/TD]
[TD]21/09/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Outbreak status[/TD]
[TD]Continuing (or date resolved not provided)[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Epidemiological unit[/TD]
[TD]Farm[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Affected animals[/TD]
[TD] [TABLE="class: TableFoyers, width: 640"]
[TR]
[TD="class: filtrer_th ta_center last"]Species[/TD]
[TD="class: filtrer_th ta_center last"]Susceptible[/TD]
[TD="class: filtrer_th ta_center last"]Cases[/TD]
[TD="class: filtrer_th ta_center last"]Deaths[/TD]
[TD="class: filtrer_th ta_center last"]Killed and disposed of[/TD]
[TD="class: filtrer_th ta_center last"]Slaughtered[/TD]
[/TR]
[TR]
[TD]Equidae[/TD]
[TD="class: ta_right"]12[/TD]
[TD="class: ta_right"]1[/TD]
[TD="class: ta_right"]0[/TD]
[TD="class: ta_right"]1[/TD]
[TD="class: ta_right"]0[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[/TABLE]

[/TD]
[/TR]
[TR]
[TD] [TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left, align: left"]Summary of outbreaks[/TD]
[TD="class: filtrer_th ta_left"]Total outbreaks: 1[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Total animals affected[/TD]
[TD] [TABLE="class: TableFoyers, width: 745"]
[TR]
[TD="class: filtrer_th ta_center last"]Species[/TD]
[TD="class: filtrer_th ta_center last"]Susceptible[/TD]
[TD="class: filtrer_th ta_center last"]Cases[/TD]
[TD="class: filtrer_th ta_center last"]Deaths[/TD]
[TD="class: filtrer_th ta_center last"]Killed and disposed of[/TD]
[TD="class: filtrer_th ta_center last"]Slaughtered[/TD]
[/TR]
[TR]
[TD]Equidae[/TD]
[TD="class: ta_right"]12[/TD]
[TD="class: ta_right"]1[/TD]
[TD="class: ta_right"]0[/TD]
[TD="class: ta_right"]1[/TD]
[TD="class: ta_right"]0[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Outbreak statistics[/TD]
[TD] [TABLE="class: TableFoyers, width: 745"]
[TR]
[TD="class: filtrer_th ta_center last"]Species[/TD]
[TD="class: filtrer_th ta_center last"]Apparent morbidity rate[/TD]
[TD="class: filtrer_th ta_center last"]Apparent mortality rate[/TD]
[TD="class: filtrer_th ta_center last"]Apparent case fatality rate[/TD]
[TD="class: filtrer_th ta_center last"]Proportion susceptible animals lost*[/TD]
[/TR]
[TR]
[TD]Equidae[/TD]
[TD="class: ta_right"]8.33%[/TD]
[TD="class: ta_right"]0.00%[/TD]
[TD="class: ta_right"]0.00%[/TD]
[TD="class: ta_right"]8.33%[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left, colspan: 2"]*Removed from the susceptible population through death, destruction and/or slaughter[/TD]
[/TR]
[/TABLE]

[/TD]
[/TR]
[TR]
[TD] Epidemiology
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left"]Source of the outbreak(s) or origin of infection[/TD]
[TD]
  • Unknown or inconclusive
[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] [/TD]
[/TR]
[TR]
[TD] Control measures
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left"]Measures applied[/TD]
[TD]
  • Surveillance within containment and/or protection zone
  • Traceability
  • Official disposal of carcasses, by-products and waste
  • Control of wildlife reservoirs
  • Selective killing and disposal
  • Control of vectors
  • Vector surveillance
  • Vaccination permitted (if a vaccine exists)
  • No treatment of affected animals
[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Measures to be applied[/TD]
[TD]
  • No other measures
[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] Diagnostic test results
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left"]Laboratory name and type[/TD]
[TD="class: filtrer_th ta_left"]Species[/TD]
[TD="class: filtrer_th ta_left"]Test[/TD]
[TD="class: filtrer_th ta_left"]Test date[/TD]
[TD="class: filtrer_th ta_left last"]Result[/TD]
[/TR]
[TR]
[TD="class: filtrer"]Friedrich-Loeffler Institute (National laboratory)[/TD]
[TD="class: filtrer"]Equidae[/TD]
[TD="class: filtrer"]reverse transcription - polymerase chain reaction (RT-PCR)[/TD]
[TD="class: filtrer"]24/09/2018[/TD]
[TD="class: filtrer cb-centree last"]Positive[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] Future Reporting
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer"]The event is continuing. Weekly follow-up reports will be submitted.[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[/TABLE]

...
http://www.oie.int/wahis_2/public/w...?page_refer=MapFullEventReport&reportid=28071
 
[TABLE="class: TableChoisir, border: 0, cellpadding: 0, cellspacing: 0"]
[TR]
[TD]

[TD="width: *, align: left"] West Nile Fever,
Germany

[/TD]
[TD="width: 1%, align: right"] [/TD]
[/TD]
[/TR]
[TR]
[TD] [TABLE="class: TableChoisir, border: 0, cellpadding: 0, cellspacing: 0"]
[TR]
[TD="class: topbigtabletitle27"]Information received on 10/10/2018 from Dr. Karin Schwabenbauer, Ministerial Dirigentin and Chief Veterinary Officer , Directorate of Animal Health, Animal Welfare, Bundesministerium f?r Ern?hrung und Landwirtschaft (BMEL) , Bonn, Germany[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] Summary
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th, width: 10%"]Report type[/TD]
[TD="width: 30%"]Follow-up report No. 4[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Date of start of the event[/TD]
[TD="width: 30%"]28/08/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Date of confirmation of the event[/TD]
[TD="width: 30%"]29/08/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Report date[/TD]
[TD="width: 30%"]09/10/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Date submitted to OIE[/TD]
[TD="width: 30%"]10/10/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Reason for notification[/TD]
[TD="width: 30%"]First occurrence of a listed disease in the country[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Causal agent[/TD]
[TD="width: 30%"]West Nile virus[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]Nature of diagnosis[/TD]
[TD="width: 30%"]Laboratory (basic), Laboratory (advanced)[/TD]
[/TR]
[TR]
[TD="class: filtrer_th, width: 10%"]This event pertains to[/TD]
[TD="width: 30%"]a defined zone within the country[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left, width: 10%"]Related reports[/TD]
[TD="width: 30%"]Immediate notification (30/08/2018)
Follow-up report No. 1 (13/09/2018)
Follow-up report No. 2 (25/09/2018)
Follow-up report No. 3 (28/09/2018)
Follow-up report No. 4 (09/10/2018) [/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] New outbreaks (1)
[TABLE="class: TableFoyers, width: 918"]
[/TABLE]

[/TD]
[/TR]
[TR]
[TD] [TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left, align: left"]Outbreak 1 (18-416-00011)[/TD]
[TD="class: filtrer_th ta_left"]Petersberg, Saalekreis, Sachsen-Anhalt[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Date of start of the outbreak[/TD]
[TD]16/09/2018[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Outbreak status[/TD]
[TD]Continuing (or date resolved not provided)[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Epidemiological unit[/TD]
[TD]Farm[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Affected animals[/TD]
[TD] [TABLE="class: TableFoyers, width: 640"]
[TR]
[TD="class: filtrer_th ta_center last"]Species[/TD]
[TD="class: filtrer_th ta_center last"]Susceptible[/TD]
[TD="class: filtrer_th ta_center last"]Cases[/TD]
[TD="class: filtrer_th ta_center last"]Deaths[/TD]
[TD="class: filtrer_th ta_center last"]Killed and disposed of[/TD]
[TD="class: filtrer_th ta_center last"]Slaughtered[/TD]
[/TR]
[TR]
[TD]Equidae[/TD]
[TD="class: ta_right"]8[/TD]
[TD="class: ta_right"]1[/TD]
[TD="class: ta_right"]0[/TD]
[TD="class: ta_right"]0[/TD]
[TD="class: ta_right"]0[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[/TABLE]

[/TD]
[/TR]
[TR]
[TD] [TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left, align: left"]Summary of outbreaks[/TD]
[TD="class: filtrer_th ta_left"]Total outbreaks: 1[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Total animals affected[/TD]
[TD] [TABLE="class: TableFoyers, width: 745"]
[TR]
[TD="class: filtrer_th ta_center last"]Species[/TD]
[TD="class: filtrer_th ta_center last"]Susceptible[/TD]
[TD="class: filtrer_th ta_center last"]Cases[/TD]
[TD="class: filtrer_th ta_center last"]Deaths[/TD]
[TD="class: filtrer_th ta_center last"]Killed and disposed of[/TD]
[TD="class: filtrer_th ta_center last"]Slaughtered[/TD]
[/TR]
[TR]
[TD]Equidae[/TD]
[TD="class: ta_right"]8[/TD]
[TD="class: ta_right"]1[/TD]
[TD="class: ta_right"]0[/TD]
[TD="class: ta_right"]0[/TD]
[TD="class: ta_right"]0[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Outbreak statistics[/TD]
[TD] [TABLE="class: TableFoyers, width: 745"]
[TR]
[TD="class: filtrer_th ta_center last"]Species[/TD]
[TD="class: filtrer_th ta_center last"]Apparent morbidity rate[/TD]
[TD="class: filtrer_th ta_center last"]Apparent mortality rate[/TD]
[TD="class: filtrer_th ta_center last"]Apparent case fatality rate[/TD]
[TD="class: filtrer_th ta_center last"]Proportion susceptible animals lost*[/TD]
[/TR]
[TR]
[TD]Equidae[/TD]
[TD="class: ta_right"]12.50%[/TD]
[TD="class: ta_right"]0.00%[/TD]
[TD="class: ta_right"]0.00%[/TD]
[TD="class: ta_right"]0.00%[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left, colspan: 2"]*Removed from the susceptible population through death, destruction and/or slaughter[/TD]
[/TR]
[/TABLE]

[/TD]
[/TR]
[TR]
[TD] Epidemiology
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left"]Source of the outbreak(s) or origin of infection[/TD]
[TD]
  • Unknown or inconclusive
[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] [/TD]
[/TR]
[TR]
[TD] Control measures
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left"]Measures applied[/TD]
[TD]
  • Surveillance within containment and/or protection zone
  • Traceability
  • Official disposal of carcasses, by-products and waste
  • Control of wildlife reservoirs
  • Control of vectors
  • Vector surveillance
  • Vaccination permitted (if a vaccine exists)
  • No treatment of affected animals
[/TD]
[/TR]
[TR]
[TD="class: filtrer_th ta_left"]Measures to be applied[/TD]
[TD]
  • No other measures
[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] Diagnostic test results
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer_th ta_left"]Laboratory name and type[/TD]
[TD="class: filtrer_th ta_left"]Species[/TD]
[TD="class: filtrer_th ta_left"]Test[/TD]
[TD="class: filtrer_th ta_left"]Test date[/TD]
[TD="class: filtrer_th ta_left last"]Result[/TD]
[/TR]
[TR]
[TD="class: filtrer"]Friedrich-Loeffler Institute (National laboratory)[/TD]
[TD="class: filtrer"]Equidae[/TD]
[TD="class: filtrer"]antibody detection ELISA[/TD]
[TD="class: filtrer"]02/10/2018[/TD]
[TD="class: filtrer cb-centree last"]Positive[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[TR]
[TD] Future Reporting
[TABLE="class: TableFoyers, width: 917"]
[TR]
[TD="class: filtrer"]The event is continuing. Weekly follow-up reports will be submitted.[/TD]
[/TR]
[/TABLE]
[/TD]
[/TR]
[/TABLE]

...
http://www.oie.int/wahis_2/public/w...?page_refer=MapFullEventReport&reportid=28211
 
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