tetano
Editor, Senior Moderator
Geriatr Gerontol Int
. 2024 Jul 22.
doi: 10.1111/ggi.14940. Online ahead of print. Relationship between imaging-derived parameters and circulating microRNAs to study the degree of lung involvement in hospitalized geriatric patients with COVID-19 pneumonia
Sara Cecchini[SUP] 1 [/SUP], Mirko Di Rosa[SUP] 2 [/SUP], Lorenzo Fantechi[SUP] 3 [/SUP], Sara Mecozzi[SUP] 1 [/SUP], Giulia Matacchione[SUP] 4 [/SUP], Angelica Giuliani[SUP] 5 [/SUP], Vladia Monsurrò[SUP] 6 [/SUP], Lorenzo Zoppi[SUP] 1 [/SUP], Maurizio Cardelli[SUP] 7 [/SUP], Roberta Galeazzi[SUP] 4 [/SUP], Rina Recchioni[SUP] 4 [/SUP], Francesca Marchegiani[SUP] 4 [/SUP], Massimo Marra[SUP] 8 [/SUP], Jacopo Sabbatinelli[SUP] 4 8 [/SUP], Andrea Corsonello[SUP] 9 [/SUP], Riccardo Sarzani[SUP] 8 10 [/SUP], Antonio Cherubini[SUP] 8 11 [/SUP], Anna Rita Bonfigli[SUP] 12 [/SUP], Daniela Fornarelli[SUP] 3 [/SUP], Enrico Paci[SUP] 1 [/SUP], Antonio Domenico Procopio[SUP] 4 8 [/SUP], Fabiola Olivieri[SUP] 4 8 [/SUP], Giuseppe Bronte[SUP] 4 8 [/SUP]
Affiliations
Aim: Chest computed tomography (CT) scan is useful to evaluate the type and extent of lung lesions in coronavirus disease 2019 (COVID-19) pneumonia. This study explored the association between radiological parameters and various circulating serum-derived markers, including microRNAs, in older patients with COVID-19 pneumonia.
Methods: A retrospective analysis was designed to study geriatric patients (≥75 years) with COVID-19 pneumonia, who underwent chest CT scan on admission, and for whom clinical data and serum samples were obtained. To quantify the extent of lung involvement, CT-score, the percentage of healthy lung (HL%), the percentage of ground glass opacity (GGO%), and the percentage of lung consolidation were assessed using computer-aided tools. The association of these parameters with two circulating microRNAs, miR-483-5p and miR-320b, previously identified as biomarkers of mortality risk in COVID-19 geriatric patients, was tested.
Results: A total of 73 patients with COVID-19 pneumonia were evaluable (median age 85 years; interquartile range 82-90 years). Among chest CT-derived parameters, the percentage of lung consolidation (HR 1.08, 95% CI 1.02-1.14), CT-score (HR 1.14, 95% CI 1.03-1.25), and HL% (HR 0.97, 95% CI 0.95-0.99) emerged as significant predictors of mortality, whereas non-significant trends toward increased mortality were observed in patients with higher GGO%. We also found a significant positive association between serum miR-483-5p and GGO% (correlation coefficient 0.28; P = 0.018) and a negative association with HL% (correlation coefficient -0.27; P = 0.023).
Conclusions: Overall, the extent of lung consolidation can be confirmed as a prognostic parameter of COVID-19 pneumonia in older patients. Among various serum-derived markers, miR-483-5p can help in exploring the degree of lung involvement, due to its association with higher GGO% and lower HL%. Geriatr Gerontol Int 2024; ••: ••-••.
Keywords: COVID‐19; computed tomography severity score; elderly; microRNA; pneumonia.
. 2024 Jul 22.
doi: 10.1111/ggi.14940. Online ahead of print. Relationship between imaging-derived parameters and circulating microRNAs to study the degree of lung involvement in hospitalized geriatric patients with COVID-19 pneumonia
Sara Cecchini[SUP] 1 [/SUP], Mirko Di Rosa[SUP] 2 [/SUP], Lorenzo Fantechi[SUP] 3 [/SUP], Sara Mecozzi[SUP] 1 [/SUP], Giulia Matacchione[SUP] 4 [/SUP], Angelica Giuliani[SUP] 5 [/SUP], Vladia Monsurrò[SUP] 6 [/SUP], Lorenzo Zoppi[SUP] 1 [/SUP], Maurizio Cardelli[SUP] 7 [/SUP], Roberta Galeazzi[SUP] 4 [/SUP], Rina Recchioni[SUP] 4 [/SUP], Francesca Marchegiani[SUP] 4 [/SUP], Massimo Marra[SUP] 8 [/SUP], Jacopo Sabbatinelli[SUP] 4 8 [/SUP], Andrea Corsonello[SUP] 9 [/SUP], Riccardo Sarzani[SUP] 8 10 [/SUP], Antonio Cherubini[SUP] 8 11 [/SUP], Anna Rita Bonfigli[SUP] 12 [/SUP], Daniela Fornarelli[SUP] 3 [/SUP], Enrico Paci[SUP] 1 [/SUP], Antonio Domenico Procopio[SUP] 4 8 [/SUP], Fabiola Olivieri[SUP] 4 8 [/SUP], Giuseppe Bronte[SUP] 4 8 [/SUP]
Affiliations
- PMID: 39037206
- DOI: 10.1111/ggi.14940
Aim: Chest computed tomography (CT) scan is useful to evaluate the type and extent of lung lesions in coronavirus disease 2019 (COVID-19) pneumonia. This study explored the association between radiological parameters and various circulating serum-derived markers, including microRNAs, in older patients with COVID-19 pneumonia.
Methods: A retrospective analysis was designed to study geriatric patients (≥75 years) with COVID-19 pneumonia, who underwent chest CT scan on admission, and for whom clinical data and serum samples were obtained. To quantify the extent of lung involvement, CT-score, the percentage of healthy lung (HL%), the percentage of ground glass opacity (GGO%), and the percentage of lung consolidation were assessed using computer-aided tools. The association of these parameters with two circulating microRNAs, miR-483-5p and miR-320b, previously identified as biomarkers of mortality risk in COVID-19 geriatric patients, was tested.
Results: A total of 73 patients with COVID-19 pneumonia were evaluable (median age 85 years; interquartile range 82-90 years). Among chest CT-derived parameters, the percentage of lung consolidation (HR 1.08, 95% CI 1.02-1.14), CT-score (HR 1.14, 95% CI 1.03-1.25), and HL% (HR 0.97, 95% CI 0.95-0.99) emerged as significant predictors of mortality, whereas non-significant trends toward increased mortality were observed in patients with higher GGO%. We also found a significant positive association between serum miR-483-5p and GGO% (correlation coefficient 0.28; P = 0.018) and a negative association with HL% (correlation coefficient -0.27; P = 0.023).
Conclusions: Overall, the extent of lung consolidation can be confirmed as a prognostic parameter of COVID-19 pneumonia in older patients. Among various serum-derived markers, miR-483-5p can help in exploring the degree of lung involvement, due to its association with higher GGO% and lower HL%. Geriatr Gerontol Int 2024; ••: ••-••.
Keywords: COVID‐19; computed tomography severity score; elderly; microRNA; pneumonia.