tetano
Editor, Senior Moderator
Genomics Proteomics Bioinformatics
. 2020 Dec 3;S1672-0229(20)30131-5.
doi: 10.1016/j.gpb.2020.09.001. Online ahead of print.
The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR
Shuhui Song[SUP] 1 [/SUP], Lina Ma[SUP] 2 [/SUP], Dong Zou[SUP] 2 [/SUP], Dongmei Tian[SUP] 3 [/SUP], Cuiping Li[SUP] 3 [/SUP], Junwei Zhu[SUP] 3 [/SUP], Meili Chen[SUP] 2 [/SUP], Anke Wang[SUP] 3 [/SUP], Yingke Ma[SUP] 3 [/SUP], Mengwei Li[SUP] 1 [/SUP], Xufei Teng[SUP] 1 [/SUP], Ying Cui[SUP] 1 [/SUP], Guangya Duan[SUP] 1 [/SUP], Mochen Zhang[SUP] 1 [/SUP], Tong Jin[SUP] 1 [/SUP], Chengmin Shi[SUP] 4 [/SUP], Zhenglin Du[SUP] 2 [/SUP], Yadong Zhang[SUP] 1 [/SUP], Chuandong Liu[SUP] 4 [/SUP], Rujiao Li[SUP] 2 [/SUP], Jingyao Zeng[SUP] 2 [/SUP], Lili Hao[SUP] 2 [/SUP], Shuai Jiang[SUP] 3 [/SUP], Hua Chen[SUP] 5 [/SUP], Dali Han[SUP] 6 [/SUP], Jingfa Xiao[SUP] 1 [/SUP], Zhang Zhang[SUP] 7 [/SUP], Wenming Zhao[SUP] 8 [/SUP], Yongbiao Xue[SUP] 9 [/SUP], Yiming Bao[SUP] 10 [/SUP]
Affiliations
Abstract
On January 22, 2020, China National Center for Bioinformation (CNCB) released the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access information resource for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates, which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline. Of particular note, 2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale. It provides all identified variants and their detailed statistics for each virus isolate, and congregates the quality score, functional annotation, and population frequency for each variant. Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available. Moreover, 2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019 (COVID-19), including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC. Furthermore, by linking with relevant databases in CNCB, 2019nCoVR offers data submission services for raw sequence reads and assembled genomes, and data sharing with NCBI. Collectively, SARS-CoV-2 is updated daily to collect the latest information on genome sequences, variants, haplotypes, and literature for a timely reflection, making 2019nCoVR a valuable resource for the global research community. 2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/.
Keywords: 2019nCoVR; Database; Genomic variation; Haplotype; SARS-CoV-2.
. 2020 Dec 3;S1672-0229(20)30131-5.
doi: 10.1016/j.gpb.2020.09.001. Online ahead of print.
The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR
Shuhui Song[SUP] 1 [/SUP], Lina Ma[SUP] 2 [/SUP], Dong Zou[SUP] 2 [/SUP], Dongmei Tian[SUP] 3 [/SUP], Cuiping Li[SUP] 3 [/SUP], Junwei Zhu[SUP] 3 [/SUP], Meili Chen[SUP] 2 [/SUP], Anke Wang[SUP] 3 [/SUP], Yingke Ma[SUP] 3 [/SUP], Mengwei Li[SUP] 1 [/SUP], Xufei Teng[SUP] 1 [/SUP], Ying Cui[SUP] 1 [/SUP], Guangya Duan[SUP] 1 [/SUP], Mochen Zhang[SUP] 1 [/SUP], Tong Jin[SUP] 1 [/SUP], Chengmin Shi[SUP] 4 [/SUP], Zhenglin Du[SUP] 2 [/SUP], Yadong Zhang[SUP] 1 [/SUP], Chuandong Liu[SUP] 4 [/SUP], Rujiao Li[SUP] 2 [/SUP], Jingyao Zeng[SUP] 2 [/SUP], Lili Hao[SUP] 2 [/SUP], Shuai Jiang[SUP] 3 [/SUP], Hua Chen[SUP] 5 [/SUP], Dali Han[SUP] 6 [/SUP], Jingfa Xiao[SUP] 1 [/SUP], Zhang Zhang[SUP] 7 [/SUP], Wenming Zhao[SUP] 8 [/SUP], Yongbiao Xue[SUP] 9 [/SUP], Yiming Bao[SUP] 10 [/SUP]
Affiliations
- PMID: 33704069
- DOI: 10.1016/j.gpb.2020.09.001
Abstract
On January 22, 2020, China National Center for Bioinformation (CNCB) released the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access information resource for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates, which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline. Of particular note, 2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale. It provides all identified variants and their detailed statistics for each virus isolate, and congregates the quality score, functional annotation, and population frequency for each variant. Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available. Moreover, 2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019 (COVID-19), including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC. Furthermore, by linking with relevant databases in CNCB, 2019nCoVR offers data submission services for raw sequence reads and assembled genomes, and data sharing with NCBI. Collectively, SARS-CoV-2 is updated daily to collect the latest information on genome sequences, variants, haplotypes, and literature for a timely reflection, making 2019nCoVR a valuable resource for the global research community. 2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/.
Keywords: 2019nCoVR; Database; Genomic variation; Haplotype; SARS-CoV-2.