tetano
Editor, Senior Moderator
Virol J. 2013 Nov 26;10(1):345. [Epub ahead of print]
Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China.
Zhong J, Liang L, Huang P, Zhu X, Zou L, Yu S, Zhang X, Zhang Y, Ni H, Yan J.
Abstract
BACKGROUND:
An influenza H3N2 epidemic occurred throughout Southern China in 2012.
METHODS:
We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011--2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed.
RESULTS:
The 2011--2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in the A/ Perth/16/2009 influenza strain. The HA-NSS061--063 and NNS160--162 glycosylation sites were prevalent among the 2011--2012 Guangdong strains but the NA-NRS402--404 site was deleted. Antigenically, there was a four-fold difference between A/Perth/16/2009 -like strains and the 2011--2012 Guangdong strains.
CONCLUSION:
Antigenic drift of the H3N2 subtype contributed to the occurrence of the Southern China influenza epidemic of 2012.
PMID:
24279698
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24279698
Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China.
Zhong J, Liang L, Huang P, Zhu X, Zou L, Yu S, Zhang X, Zhang Y, Ni H, Yan J.
Abstract
BACKGROUND:
An influenza H3N2 epidemic occurred throughout Southern China in 2012.
METHODS:
We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011--2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed.
RESULTS:
The 2011--2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in the A/ Perth/16/2009 influenza strain. The HA-NSS061--063 and NNS160--162 glycosylation sites were prevalent among the 2011--2012 Guangdong strains but the NA-NRS402--404 site was deleted. Antigenically, there was a four-fold difference between A/Perth/16/2009 -like strains and the 2011--2012 Guangdong strains.
CONCLUSION:
Antigenic drift of the H3N2 subtype contributed to the occurrence of the Southern China influenza epidemic of 2012.
PMID:
24279698
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24279698