tetano
Editor, Senior Moderator
Immune Netw. 2016 Oct;16(5):311-315. Epub 2016 Oct 25.
[h=1]Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea.[/h] Moon HJ[SUP]1[/SUP], Oh JS[SUP]2[/SUP], Na W[SUP]3[/SUP], Yeom M[SUP]3[/SUP], Han SY[SUP]1[/SUP], Kim SJ[SUP]1[/SUP], Park BK[SUP]4[/SUP], Song DS[SUP]3[/SUP], Kang BK[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.
[h=4]KEYWORDS:[/h] H1N1; Influenza; Pig; Vaccine
PMID: 27799877 DOI: 10.4110/in.2016.16.5.311
[PubMed - in process]
[h=1]Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea.[/h] Moon HJ[SUP]1[/SUP], Oh JS[SUP]2[/SUP], Na W[SUP]3[/SUP], Yeom M[SUP]3[/SUP], Han SY[SUP]1[/SUP], Kim SJ[SUP]1[/SUP], Park BK[SUP]4[/SUP], Song DS[SUP]3[/SUP], Kang BK[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.
[h=4]KEYWORDS:[/h] H1N1; Influenza; Pig; Vaccine
PMID: 27799877 DOI: 10.4110/in.2016.16.5.311
[PubMed - in process]