Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea

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nfect Genet Evol. 2017 May 3. pii: S1567-1348(17)30152-1. doi: 10.1016/j.meegid.2017.05.001. [Epub ahead of print] [h=1]Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea.[/h] Kim YI[SUP]1[/SUP], Park SJ[SUP]1[/SUP], Kwon HI[SUP]1[/SUP], Kim EH[SUP]1[/SUP], Si YJ[SUP]1[/SUP], Jeong JH[SUP]1[/SUP], Lee IW[SUP]1[/SUP], Nguyen HD[SUP]1[/SUP], Kwon JJ[SUP]1[/SUP], Choi WS[SUP]1[/SUP], Song MS[SUP]1[/SUP], Kim CJ[SUP]2[/SUP], Choi YK[SUP]3[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] During the outbreaks of highly pathogenic avian influenza (HPAI) H5N6 viruses in 2016 in South Korea, novel H5N8 viruses were also isolated from migratory birds. Phylogenetic analysis revealed that the HA gene of these H5N8 viruses belonged to clade 2.3.4.4, similarly to recent H5Nx viruses, and originated from A/Brk/Korea/Gochang1/14(H5N8), a minor lineage of H5N8 that appeared in 2014 and then disappeared. At least four reassortment events occurred with different subtypes (H5N8, H7N7, H3N8 and H10N7) and a chicken challenge study revealed that they were classified as HPAI viruses according to OIE criteria.
Copyright ? 2017. Published by Elsevier B.V.


PMID: 28477974 DOI: 10.1016/j.meegid.2017.05.001