tetano
Editor, Senior Moderator
Infect Genet Evol. 2015 Aug 18. pii: S1567-1348(15)00340-8. doi: 10.1016/j.meegid.2015.08.017. [Epub ahead of print]
[h=1]Genetic and biological characterization of two novel reassortant H5N6 swine influenza viruses in mice and chickens.[/h] Li X[SUP]1[/SUP], Fu Y[SUP]2[/SUP], Yang J[SUP]2[/SUP], Guo J[SUP]2[/SUP], He J[SUP]2[/SUP], Guo J[SUP]2[/SUP], Weng S[SUP]2[/SUP], Jia Y[SUP]2[/SUP], Liu B[SUP]2[/SUP], Li X[SUP]2[/SUP], Zhu Q[SUP]3[/SUP], Chen H[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Novel H5N6 influenza A viruses have infected birds and human beings and caused four human clinical cases in China since 2014. Pig, as a mixing vessel, plays an important role for influenza virus reassortment and transmission. Towards this, routine surveillance for swine influenza in Guangdong province was conducted in 2014. In this study, we reported the biological characterization of two H5N6 influenza viruses isolated from healthy pigs in Guangdong province. Genetic analysis indicates that the two viruses are reassortants of 2.3.4.4 H5N1 and H6N6 avian influenza viruses with a high similarity to duck and human H5N6 influenza viruses isolated from Guangdong province. The data from chicken and mouse experiments show that the viruses are highly pathogenic in chickens and result in a systemic infection, and replicate in the mouse lung accompanying with a clinical inflammatory pathology. The results of the study demonstrate the two H5N6 influenza viruses isolated from swine are the avian-originated viruses and have not adapted to swine population yet. However, they might keep evolving and pose a potential risk to public health and continued surveillance of swine influenza should be strengthened.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] H5N6; Influenza virus; Public health; Reassortment; Swine
PMID: 26296602 [PubMed - as supplied by publisher]
[h=1]Genetic and biological characterization of two novel reassortant H5N6 swine influenza viruses in mice and chickens.[/h] Li X[SUP]1[/SUP], Fu Y[SUP]2[/SUP], Yang J[SUP]2[/SUP], Guo J[SUP]2[/SUP], He J[SUP]2[/SUP], Guo J[SUP]2[/SUP], Weng S[SUP]2[/SUP], Jia Y[SUP]2[/SUP], Liu B[SUP]2[/SUP], Li X[SUP]2[/SUP], Zhu Q[SUP]3[/SUP], Chen H[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Novel H5N6 influenza A viruses have infected birds and human beings and caused four human clinical cases in China since 2014. Pig, as a mixing vessel, plays an important role for influenza virus reassortment and transmission. Towards this, routine surveillance for swine influenza in Guangdong province was conducted in 2014. In this study, we reported the biological characterization of two H5N6 influenza viruses isolated from healthy pigs in Guangdong province. Genetic analysis indicates that the two viruses are reassortants of 2.3.4.4 H5N1 and H6N6 avian influenza viruses with a high similarity to duck and human H5N6 influenza viruses isolated from Guangdong province. The data from chicken and mouse experiments show that the viruses are highly pathogenic in chickens and result in a systemic infection, and replicate in the mouse lung accompanying with a clinical inflammatory pathology. The results of the study demonstrate the two H5N6 influenza viruses isolated from swine are the avian-originated viruses and have not adapted to swine population yet. However, they might keep evolving and pose a potential risk to public health and continued surveillance of swine influenza should be strengthened.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] H5N6; Influenza virus; Public health; Reassortment; Swine
PMID: 26296602 [PubMed - as supplied by publisher]