tetano
Editor, Senior Moderator
Genet Mol Biol
. 2020 Nov 23;44(1 Suppl 1):e20200212.
doi: 10.1590/1678-4685-GMB-2020-0212. eCollection 2020.
Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
Fernando Moreira Simabuco[SUP] 1 [/SUP], Rodrigo Esaki Tamura[SUP] 2 [/SUP], Isadora Carolina Betim Pavan[SUP] 1 3 [/SUP], Mirian Galliote Morale[SUP] 4 [/SUP], Armando Morais Ventura[SUP] 5 [/SUP]
Affiliations
Abstract
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19, which is characterized by cough, fever, fatigue, and severe cases of pneumonia, has affected more than 23 million people worldwide until August 25th, 2020. Here, we present a review of the cellular mechanisms associated with human coronavirus replication, including the unique molecular events related to the replication transcription complex (RTC) of coronaviruses. We also present information regarding the interactions between each viral protein and cellular proteins associated to known host-pathogen implications for the coronavirus biology. Finally, a specific topic addresses the current attempts for pharmacological interventions against COVID-19, highlighting the possible effects of each drug on the molecular events of viral replication. This review intends to aid future studies for a better understanding of the SARS-CoV-2 replication cycle and the development of pharmacological approaches targeting COVID-19.
. 2020 Nov 23;44(1 Suppl 1):e20200212.
doi: 10.1590/1678-4685-GMB-2020-0212. eCollection 2020.
Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses
Fernando Moreira Simabuco[SUP] 1 [/SUP], Rodrigo Esaki Tamura[SUP] 2 [/SUP], Isadora Carolina Betim Pavan[SUP] 1 3 [/SUP], Mirian Galliote Morale[SUP] 4 [/SUP], Armando Morais Ventura[SUP] 5 [/SUP]
Affiliations
- PMID: 33237152
- DOI: 10.1590/1678-4685-GMB-2020-0212
Abstract
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 along with MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19, which is characterized by cough, fever, fatigue, and severe cases of pneumonia, has affected more than 23 million people worldwide until August 25th, 2020. Here, we present a review of the cellular mechanisms associated with human coronavirus replication, including the unique molecular events related to the replication transcription complex (RTC) of coronaviruses. We also present information regarding the interactions between each viral protein and cellular proteins associated to known host-pathogen implications for the coronavirus biology. Finally, a specific topic addresses the current attempts for pharmacological interventions against COVID-19, highlighting the possible effects of each drug on the molecular events of viral replication. This review intends to aid future studies for a better understanding of the SARS-CoV-2 replication cycle and the development of pharmacological approaches targeting COVID-19.