-
FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster. The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website. By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
-
We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.
General discussion of One Health concept
- Thread starter Emily
- Start date
bertrand789
Well-known member
Pr?alable :
la gestion de l'acc?s aux d?finitions des mots en usage, dans une soci?t?, cela a toujours ?t? un sujet de politique avec un petit p. Pour moi, cette gestion devrait ?tre confi?e et g?r?e, par les enseignants. Mais comme, il semble qu'en aucun lieu, ils ont le courage d'assumer leurs devoirs , on en est l? ...
Un vrai bonheur le dernier lien, je ne le connaissais pas. Tu* m?rites plein de bisous, en p?riode de confinement, et en public. Je d?guste, la suite viendra ensuite ...
* d?sol? , j'ai os? le Tu sans avoir demand?.
la gestion de l'acc?s aux d?finitions des mots en usage, dans une soci?t?, cela a toujours ?t? un sujet de politique avec un petit p. Pour moi, cette gestion devrait ?tre confi?e et g?r?e, par les enseignants. Mais comme, il semble qu'en aucun lieu, ils ont le courage d'assumer leurs devoirs , on en est l? ...
Un vrai bonheur le dernier lien, je ne le connaissais pas. Tu* m?rites plein de bisous, en p?riode de confinement, et en public. Je d?guste, la suite viendra ensuite ...
* d?sol? , j'ai os? le Tu sans avoir demand?.
Emily
Editor, Senior Moderator
https://www.zenbycat.org/blog/connection-between-fip-and-covid19
Update on the connection between FIP and Covid19 from Dr Niels C. Pedersen:
Dear Veterinarians, cat owners and public: I am being increasingly questioned about the relationship of GS-441524 and a very promising treatment for Covid-19, Remdesivir. GS-441524 is the biologically active component of Remdesivir and has been widely used around the world to safely and effectively cure cats of feline infectious peritonitis (FIP) for over 18 months. FIP is a common and highly fatal coronavirus disease of cats. GS-441424 and Remdesivir are almost identical drugs. Remdesivir is the form of GS-441424 that Gilead Sciences has chosen to use in humans for COVID-19 and is now in clinical trials in China, USA and several other countries. Remdesivir is what is known as a prodrug. A prodrug is altered by infected cells to yield the active ingredient, which in this case is basically GS-441524 with the addition of one phosphate group (i.e., GS-5734). Gilead scientists slightly altered GS-5734 to protect the added phosphate group and allow absorption into cells. This form of GS-441524 is what is known as Remdesivir. Once in the cells, cellular enzymes remove the protection to yield GS-5734. GS-5734 is further activated by the addition of two more phosphates in the cells to the triphosphate form of GS-441524. This is the molecule that inhibits the production of viral RNA. We chose to use GS-441524 for treatment of the coronavirus disease FIP because it had identical antiviral properties to Remdesivir and at the time was not under consideration by Gilead Sciences for use in humans. GS-441524 is also much cheaper to make than Remdesivir. Therefore, there was no apparent conflict with using one form for cats and another form for humans. However, Gilead came to believe that our cat research would interfere with their ability to get Remdesivir approved for humans and refused to grant animal rights for GS-441524. This refusal, coupled with the desperate need around the world for the treatment of FIP, led to a Chinese black market for GS-441524. FIP is also a significant problem in pet cats in China, and Chinese cat owners were even more desperate for a treatment for FIP than owners in other countries. The first papers describing GS-441524 treatment of cats with FIP were published in 2018 and 2019 and thousands of cats have been treated since then. In spite of this experience, the medical profession, including researchers, have been seemingly unaware of the use of GS-441524 for a coronavirus disease of cats and its relationship to Remdesivir. Veterinarians also have considerable experience with coronaviruses, coronavirus diseases, and coronavirus vaccines for swine, calves and poultry that has gone unappreciated. Pet ferrets also suffer a severe FIP-like disease caused by their own species of coronavirus.
What will happen to supplies of GS-441524 for cats if Remdesivir is proven to be safe and effective as a treatment for Covid-19? GS-441524 is the first critical step in the production of Remdesivir and it is logical to assume that there will be a competition between cats and humans for it. On a positive note, world wide approval for Remdesivir may also help change minds against granting animal rights for GS-441524. If approved for human use, Remdesivir, if not GS-441524, would become "legally" available through veterinarians. However, the safety and efficacy of Remdesivir for FIP has not been established. -Niels C. Pedersen, DVM, PhD, School of Veterinary Medicine, UC Davis.
Update on the connection between FIP and Covid19 from Dr Niels C. Pedersen:
Dear Veterinarians, cat owners and public: I am being increasingly questioned about the relationship of GS-441524 and a very promising treatment for Covid-19, Remdesivir. GS-441524 is the biologically active component of Remdesivir and has been widely used around the world to safely and effectively cure cats of feline infectious peritonitis (FIP) for over 18 months. FIP is a common and highly fatal coronavirus disease of cats. GS-441424 and Remdesivir are almost identical drugs. Remdesivir is the form of GS-441424 that Gilead Sciences has chosen to use in humans for COVID-19 and is now in clinical trials in China, USA and several other countries. Remdesivir is what is known as a prodrug. A prodrug is altered by infected cells to yield the active ingredient, which in this case is basically GS-441524 with the addition of one phosphate group (i.e., GS-5734). Gilead scientists slightly altered GS-5734 to protect the added phosphate group and allow absorption into cells. This form of GS-441524 is what is known as Remdesivir. Once in the cells, cellular enzymes remove the protection to yield GS-5734. GS-5734 is further activated by the addition of two more phosphates in the cells to the triphosphate form of GS-441524. This is the molecule that inhibits the production of viral RNA. We chose to use GS-441524 for treatment of the coronavirus disease FIP because it had identical antiviral properties to Remdesivir and at the time was not under consideration by Gilead Sciences for use in humans. GS-441524 is also much cheaper to make than Remdesivir. Therefore, there was no apparent conflict with using one form for cats and another form for humans. However, Gilead came to believe that our cat research would interfere with their ability to get Remdesivir approved for humans and refused to grant animal rights for GS-441524. This refusal, coupled with the desperate need around the world for the treatment of FIP, led to a Chinese black market for GS-441524. FIP is also a significant problem in pet cats in China, and Chinese cat owners were even more desperate for a treatment for FIP than owners in other countries. The first papers describing GS-441524 treatment of cats with FIP were published in 2018 and 2019 and thousands of cats have been treated since then. In spite of this experience, the medical profession, including researchers, have been seemingly unaware of the use of GS-441524 for a coronavirus disease of cats and its relationship to Remdesivir. Veterinarians also have considerable experience with coronaviruses, coronavirus diseases, and coronavirus vaccines for swine, calves and poultry that has gone unappreciated. Pet ferrets also suffer a severe FIP-like disease caused by their own species of coronavirus.
What will happen to supplies of GS-441524 for cats if Remdesivir is proven to be safe and effective as a treatment for Covid-19? GS-441524 is the first critical step in the production of Remdesivir and it is logical to assume that there will be a competition between cats and humans for it. On a positive note, world wide approval for Remdesivir may also help change minds against granting animal rights for GS-441524. If approved for human use, Remdesivir, if not GS-441524, would become "legally" available through veterinarians. However, the safety and efficacy of Remdesivir for FIP has not been established. -Niels C. Pedersen, DVM, PhD, School of Veterinary Medicine, UC Davis.
bertrand789
Well-known member
Bien,
le corps des v?t?rinaires, en France, a ?t? cr?? et aid? pour mettre en œuvre les actions collectives: donc la cr?ation de la partie publique. La partie v?t?rinaire priv?e est un sous-produit de cette n?cessit? . La formation reposait sur la notion de Ma?tre. La possibilit? de contester les erreurs d'un Ma?tre n'a fait l'objet de possibles que bien plus tard. La lecture des premier trait? v?t?rinaire ont un mode r?dactionnel qui refl?te cette situation. J'ai v?cu cela , ce qui m'a permis de vivre tr?s t?t ce que le pire des enseignants peut ?tre. Mais j'ai aussi eu le bonheur d'entrevoir qu'ils ne sont pas tous comme cela. Le "pourri" est devenu directeur de l’?cole, ce qui en dit long, sur le niveau de cette structure... Mais il n'a jamais ?t? membre de l'acad?mie v?t?rinaire de France.
Cette corporation : les v?t?rinaires a tr?s vite induit la cr?ation , en France de cette structure l' O. I. E , qui, dans la pratique a un fonctionnement proche de L'O.M.S :
Tout le monde sait que bien des chiffres produit sont faux , mais l'on doit faire avec ... quelques exemples ?clairant parlant de tous:
- les dindes sauvages am?ricaines sont, par principe, sensible aux U.S.A , qu'? ce que l'on veut ...
- la communication officielle de la Russie ou de la Chine est de m?me niveau pour les sangliers
- la Cor?e du Nord est, elle , un mod?le de communication.
Comme j'ai eu le bonheur d'avoir une double formation v?to et h?pital , j'ai eu droit tr?s t?t ? voir le fonctionnement des deux corps professoraux. Ce n'est en rien un hasard si je me suis tr?s t?t int?ress? ? l'histoire des d?finitions. En changeant de lieu, je devais adopter un autre syst?me de d?finition. Le sujet du moment en France c'est la d?finition de maladie professionnelle .
http://www.travail-et-securite.fr/ts...20VIVANTS.html
Les liens non accessible en p?riode crise , c'est une habitude moderne ...
Dans ces deux corporations, se pose la question des d?finitions de mots et aussi des outils, donc qu'est-ce qu'un m?dicament ?
Pour la partie v?t?rinaire cela est formalis? :
https://www.oie.int/fr/a-propos/prin...-fondamentaux/
l'?tat des lieux ONE HEALTH qui n'est qu'? l'?tat de chenille .
https://www.oie.int/fr/pour-les-medias/une-seule-sante/
Moi, par exemple, je ne souhaite plus m'occuper d'animaux de ferme d?tenus par des producteurs qui ne respectent pas le sol. J'ai l'impression que faire cela c'est perdre du temps .
Regarder cette vid?o
https://www.youtube.com/watch?v=klzzkv11NUk&t=35s
Je suis donc d'accord, il y a un petit probl?me politique :
https://masticadoresdeletrasfocus.wo...i-el-aallaoui/
le corps des v?t?rinaires, en France, a ?t? cr?? et aid? pour mettre en œuvre les actions collectives: donc la cr?ation de la partie publique. La partie v?t?rinaire priv?e est un sous-produit de cette n?cessit? . La formation reposait sur la notion de Ma?tre. La possibilit? de contester les erreurs d'un Ma?tre n'a fait l'objet de possibles que bien plus tard. La lecture des premier trait? v?t?rinaire ont un mode r?dactionnel qui refl?te cette situation. J'ai v?cu cela , ce qui m'a permis de vivre tr?s t?t ce que le pire des enseignants peut ?tre. Mais j'ai aussi eu le bonheur d'entrevoir qu'ils ne sont pas tous comme cela. Le "pourri" est devenu directeur de l’?cole, ce qui en dit long, sur le niveau de cette structure... Mais il n'a jamais ?t? membre de l'acad?mie v?t?rinaire de France.
Cette corporation : les v?t?rinaires a tr?s vite induit la cr?ation , en France de cette structure l' O. I. E , qui, dans la pratique a un fonctionnement proche de L'O.M.S :
Tout le monde sait que bien des chiffres produit sont faux , mais l'on doit faire avec ... quelques exemples ?clairant parlant de tous:
- les dindes sauvages am?ricaines sont, par principe, sensible aux U.S.A , qu'? ce que l'on veut ...
- la communication officielle de la Russie ou de la Chine est de m?me niveau pour les sangliers
- la Cor?e du Nord est, elle , un mod?le de communication.
Comme j'ai eu le bonheur d'avoir une double formation v?to et h?pital , j'ai eu droit tr?s t?t ? voir le fonctionnement des deux corps professoraux. Ce n'est en rien un hasard si je me suis tr?s t?t int?ress? ? l'histoire des d?finitions. En changeant de lieu, je devais adopter un autre syst?me de d?finition. Le sujet du moment en France c'est la d?finition de maladie professionnelle .
http://www.travail-et-securite.fr/ts...20VIVANTS.html
Les liens non accessible en p?riode crise , c'est une habitude moderne ...
Dans ces deux corporations, se pose la question des d?finitions de mots et aussi des outils, donc qu'est-ce qu'un m?dicament ?
Pour la partie v?t?rinaire cela est formalis? :
https://www.oie.int/fr/a-propos/prin...-fondamentaux/
l'?tat des lieux ONE HEALTH qui n'est qu'? l'?tat de chenille .
https://www.oie.int/fr/pour-les-medias/une-seule-sante/
Moi, par exemple, je ne souhaite plus m'occuper d'animaux de ferme d?tenus par des producteurs qui ne respectent pas le sol. J'ai l'impression que faire cela c'est perdre du temps .
Regarder cette vid?o
https://www.youtube.com/watch?v=klzzkv11NUk&t=35s
Je suis donc d'accord, il y a un petit probl?me politique :
L'INFLUENCE DES CORONAVIRUS DANS LE SYST?ME INTERNATIONAL POST BIPOLAIRE par Ali El Aallaoui
https://masticadoresdeletrasfocus.wo...i-el-aallaoui/
bertrand789
Well-known member
The silence of this gentleman disturbs me:
Agriculture and Consumer Protection,
Qu Dongyu (Chinese: ???; pinyin: Q? D?ngy?; born October 1963) took up office as the ninth Director-General of the Food and Agriculture Organization (FAO) of the United Nations
https://en.wikipedia.org/wiki/Qu_Dongyu
But hey, it's the F.A.O, so a place where science is absent, or?
In the dia on the possible origins of a lab, these are the words of conspirators or this gentleman given his function, endorses the questions?
On the quality of the choice of vaccines in the eyes of citizens, he has nothing to say either?
So it's a good job, isn't it?
Agriculture and Consumer Protection,
Qu Dongyu (Chinese: ???; pinyin: Q? D?ngy?; born October 1963) took up office as the ninth Director-General of the Food and Agriculture Organization (FAO) of the United Nations
https://en.wikipedia.org/wiki/Qu_Dongyu
But hey, it's the F.A.O, so a place where science is absent, or?
In the dia on the possible origins of a lab, these are the words of conspirators or this gentleman given his function, endorses the questions?
On the quality of the choice of vaccines in the eyes of citizens, he has nothing to say either?
So it's a good job, isn't it?
bertrand789
Well-known member
ce doit ?tre pour sourire :
https://wahis.oie.int/#/report-info?reportId=33320
It seems that there are scientists here or in China, but publications are rarely or never, right?
https://wahis.oie.int/#/report-info?reportId=33320
It seems that there are scientists here or in China, but publications are rarely or never, right?