tetano
Editor, Senior Moderator
Gene Rep
. 2020 Sep;20:100752.
doi: 10.1016/j.genrep.2020.100752. Epub 2020 Jun 15.
Novel SARS-CoV-2/COVID-19: Origin, Pathogenesis, Genes and Genetic Variations, Immune Responses and Phylogenetic Analysis
Yasmeen Junejo[SUP] 1 [/SUP], Mehmet Ozaslan[SUP] 2 [/SUP], Muhamad Safdar[SUP] 2 3 [/SUP], Rozhgar A Khailany[SUP] 4 5 [/SUP], SaifUr Rehman[SUP] 6 [/SUP], Wasim Yousaf[SUP] 7 [/SUP], Musarrat Abbas Khan[SUP] 3 [/SUP]
Affiliations
Abstract
In this review, we focused on the origins of the novel coronavirus (SARS-CoV-2), origin, pathogenesis, immune responses, genes and genetic variations, phylogenetic analyses, and potential therapeutic strategies to summarize approaches for developing broadly effective preventions and vaccines to cope COVID-19. Towards the end of 2019, SARS-CoV-2 has emerged in association with the SARS, later was named COVID-19 caused an environment of chaos worldwide and infected a massive number of lives. Since these epidemics or pandemics had spread to 210 countries and territories around the world and 2 international conveyances with 6,467,229 confirmed cases, including, 382,766 deaths, as of June 03, 2020 (https://www.worldometers.info/coronavirus/), hence the World Health Organization declared it as a global Public Health Emergency. There are no clinically approved vaccines or antiviral drugs available for either of new or old corona infections; thus, the development of effective therapeutic and preventive strategies that can be readily available to cope with these strains.
Keywords: ACE2, angiotensin receptor 2; BCoV, bovine coronavirus; COVID-19, Coronavirus Disease 2019; Evolution; IBV, avian infectious bronchitis viruses; Origin; Pathogenesis; Phylogenetic analysis; SARS-CoV-2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TGEV, transmissible gastroenteritis virus; Variations; WHO, World Health Organization.
. 2020 Sep;20:100752.
doi: 10.1016/j.genrep.2020.100752. Epub 2020 Jun 15.
Novel SARS-CoV-2/COVID-19: Origin, Pathogenesis, Genes and Genetic Variations, Immune Responses and Phylogenetic Analysis
Yasmeen Junejo[SUP] 1 [/SUP], Mehmet Ozaslan[SUP] 2 [/SUP], Muhamad Safdar[SUP] 2 3 [/SUP], Rozhgar A Khailany[SUP] 4 5 [/SUP], SaifUr Rehman[SUP] 6 [/SUP], Wasim Yousaf[SUP] 7 [/SUP], Musarrat Abbas Khan[SUP] 3 [/SUP]
Affiliations
- PMID: 32566803
- PMCID: PMC7295489
- DOI: 10.1016/j.genrep.2020.100752
Abstract
In this review, we focused on the origins of the novel coronavirus (SARS-CoV-2), origin, pathogenesis, immune responses, genes and genetic variations, phylogenetic analyses, and potential therapeutic strategies to summarize approaches for developing broadly effective preventions and vaccines to cope COVID-19. Towards the end of 2019, SARS-CoV-2 has emerged in association with the SARS, later was named COVID-19 caused an environment of chaos worldwide and infected a massive number of lives. Since these epidemics or pandemics had spread to 210 countries and territories around the world and 2 international conveyances with 6,467,229 confirmed cases, including, 382,766 deaths, as of June 03, 2020 (https://www.worldometers.info/coronavirus/), hence the World Health Organization declared it as a global Public Health Emergency. There are no clinically approved vaccines or antiviral drugs available for either of new or old corona infections; thus, the development of effective therapeutic and preventive strategies that can be readily available to cope with these strains.
Keywords: ACE2, angiotensin receptor 2; BCoV, bovine coronavirus; COVID-19, Coronavirus Disease 2019; Evolution; IBV, avian infectious bronchitis viruses; Origin; Pathogenesis; Phylogenetic analysis; SARS-CoV-2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TGEV, transmissible gastroenteritis virus; Variations; WHO, World Health Organization.