tetano
Editor, Senior Moderator
Gastroenterol Hepatol
. 2022 Oct 12;S0210-5705(22)00233-3.
doi: 10.1016/j.gastrohep.2022.10.007. Online ahead of print.
Gastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project)
[Article in English, Spanish]
Karina Cárdenas-Jaén[SUP] 1 [/SUP], Sergio A Sánchez-Luna[SUP] 2 [/SUP], Alicia Vaillo-Rocamora[SUP] 1 [/SUP], Micaela Riat Castro-Zocchi[SUP] 3 [/SUP], Laura Guberna-Blanco[SUP] 3 [/SUP], Daniel Useros-Brañas[SUP] 4 [/SUP], José M Remes-Troche[SUP] 5 [/SUP], Antonio Ramos-De la Medina[SUP] 5 [/SUP], Bryan A Priego-Parra[SUP] 5 [/SUP], José A Velarde-Ruiz Velasco[SUP] 6 [/SUP], Pedro Martínez-Ayala[SUP] 6 [/SUP], Álvaro Urzúa[SUP] 7 [/SUP], Dannette Guiñez-Francois[SUP] 8 [/SUP], Katarzyna M Pawlak[SUP] 9 [/SUP], Katarzyna Kozłowska-Petriczko[SUP] 10 [/SUP], Irati Gorroño-Zamalloa[SUP] 11 [/SUP], Clara Urteaga-Casares[SUP] 11 [/SUP], Inmaculada Ortiz-Polo[SUP] 12 [/SUP], Adolfo Del Val Antoñana[SUP] 12 [/SUP], Edgard E Lozada-Hernández[SUP] 13 [/SUP], Enrique Obregón-Moreno[SUP] 13 [/SUP], Guillermo García-Rayado[SUP] 14 [/SUP], María José Domper-Arnal[SUP] 14 [/SUP], Diego Casas-Deza[SUP] 15 [/SUP], Elena I Esteban-Cabello[SUP] 16 [/SUP], Luis A Díaz[SUP] 17 [/SUP], Arnoldo Riquelme[SUP] 17 [/SUP], Helena Martínez-Lozano[SUP] 18 [/SUP], Francisco Navarro-Romero[SUP] 19 [/SUP], Ignasi Olivas[SUP] 20 [/SUP], Guillem Iborra-Muñoz[SUP] 21 [/SUP], Alicia Calero-Amaro[SUP] 22 [/SUP], Ibán Caravaca-García[SUP] 22 [/SUP], Francisco J Lacueva-Gómez[SUP] 22 [/SUP], Rubén Pastor-Mateu[SUP] 23 [/SUP], Berta Lapeña-Muñoz[SUP] 24 [/SUP], Violeta Sastre-Lozano[SUP] 25 [/SUP], Nazaret M Pizarro-Vega[SUP] 26 [/SUP], Luigi Melcarne[SUP] 27 [/SUP], Marc Pedrosa-Aragón[SUP] 28 [/SUP], José J Mira[SUP] 29 [/SUP], Aurora Mula MStat[SUP] 30 [/SUP], Irene Carrillo[SUP] 31 [/SUP], Enrique de-Madaria[SUP] 32 [/SUP]
Affiliations
Abstract
Background: retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aims was to prospectively evaluate GI manifestations in patients hospitalized for COVID-19.
Methods: this international multicentre prospective cohort study recruited COVID-19 patients hospitalized at 31 centres in Spain, Mexico, Chile, and Poland, between May-September 2020. Patients were followed-up until 15 days post-discharge and completed comprehensive questionnaires assessing GI symptoms and complications. A descriptive analysis as well as a bivariate and multivariate analysis were performer using binary logistic regression. P<0.05 was considered significant.
Results: eight hundred twenty-nine patients were enrolled; 129 (15.6%) had severe COVID-19, 113 (13.7%) required ICU admission, and 43 (5.2%) died. Upon admission, the most prevalent GI symptoms were anorexia (n=413; 49.8%), diarrhoea (n=327; 39.4%), nausea/vomiting (n=227; 27.4%), and abdominal pain (n=172; 20.7%), which were mild/moderate throughout the disease and resolved during follow-up. One-third of patients exhibited liver injury. Non-severe COVID-19 was associated with ≥2 GI symptoms upon admission (OR 0.679; 95% CI 0.464-0.995; p=0.046) or diarrhoea during hospitalization (OR 0.531; 95% CI 0.328-0.860; p=0.009). Multivariate analysis revealed that worse hospital outcomes were not independently associated with liver injury or GI symptoms.
Keywords: COVID-19; complicaciones gastrointestinales; gastrointestinal complications; gastrointestinal symptoms; hepatitis; hospitalización; hospitalization; síntomas gastrointestinales.
. 2022 Oct 12;S0210-5705(22)00233-3.
doi: 10.1016/j.gastrohep.2022.10.007. Online ahead of print.
Gastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project)
[Article in English, Spanish]
Karina Cárdenas-Jaén[SUP] 1 [/SUP], Sergio A Sánchez-Luna[SUP] 2 [/SUP], Alicia Vaillo-Rocamora[SUP] 1 [/SUP], Micaela Riat Castro-Zocchi[SUP] 3 [/SUP], Laura Guberna-Blanco[SUP] 3 [/SUP], Daniel Useros-Brañas[SUP] 4 [/SUP], José M Remes-Troche[SUP] 5 [/SUP], Antonio Ramos-De la Medina[SUP] 5 [/SUP], Bryan A Priego-Parra[SUP] 5 [/SUP], José A Velarde-Ruiz Velasco[SUP] 6 [/SUP], Pedro Martínez-Ayala[SUP] 6 [/SUP], Álvaro Urzúa[SUP] 7 [/SUP], Dannette Guiñez-Francois[SUP] 8 [/SUP], Katarzyna M Pawlak[SUP] 9 [/SUP], Katarzyna Kozłowska-Petriczko[SUP] 10 [/SUP], Irati Gorroño-Zamalloa[SUP] 11 [/SUP], Clara Urteaga-Casares[SUP] 11 [/SUP], Inmaculada Ortiz-Polo[SUP] 12 [/SUP], Adolfo Del Val Antoñana[SUP] 12 [/SUP], Edgard E Lozada-Hernández[SUP] 13 [/SUP], Enrique Obregón-Moreno[SUP] 13 [/SUP], Guillermo García-Rayado[SUP] 14 [/SUP], María José Domper-Arnal[SUP] 14 [/SUP], Diego Casas-Deza[SUP] 15 [/SUP], Elena I Esteban-Cabello[SUP] 16 [/SUP], Luis A Díaz[SUP] 17 [/SUP], Arnoldo Riquelme[SUP] 17 [/SUP], Helena Martínez-Lozano[SUP] 18 [/SUP], Francisco Navarro-Romero[SUP] 19 [/SUP], Ignasi Olivas[SUP] 20 [/SUP], Guillem Iborra-Muñoz[SUP] 21 [/SUP], Alicia Calero-Amaro[SUP] 22 [/SUP], Ibán Caravaca-García[SUP] 22 [/SUP], Francisco J Lacueva-Gómez[SUP] 22 [/SUP], Rubén Pastor-Mateu[SUP] 23 [/SUP], Berta Lapeña-Muñoz[SUP] 24 [/SUP], Violeta Sastre-Lozano[SUP] 25 [/SUP], Nazaret M Pizarro-Vega[SUP] 26 [/SUP], Luigi Melcarne[SUP] 27 [/SUP], Marc Pedrosa-Aragón[SUP] 28 [/SUP], José J Mira[SUP] 29 [/SUP], Aurora Mula MStat[SUP] 30 [/SUP], Irene Carrillo[SUP] 31 [/SUP], Enrique de-Madaria[SUP] 32 [/SUP]
Affiliations
- PMID: 36243249
- DOI: 10.1016/j.gastrohep.2022.10.007
Abstract
Background: retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aims was to prospectively evaluate GI manifestations in patients hospitalized for COVID-19.
Methods: this international multicentre prospective cohort study recruited COVID-19 patients hospitalized at 31 centres in Spain, Mexico, Chile, and Poland, between May-September 2020. Patients were followed-up until 15 days post-discharge and completed comprehensive questionnaires assessing GI symptoms and complications. A descriptive analysis as well as a bivariate and multivariate analysis were performer using binary logistic regression. P<0.05 was considered significant.
Results: eight hundred twenty-nine patients were enrolled; 129 (15.6%) had severe COVID-19, 113 (13.7%) required ICU admission, and 43 (5.2%) died. Upon admission, the most prevalent GI symptoms were anorexia (n=413; 49.8%), diarrhoea (n=327; 39.4%), nausea/vomiting (n=227; 27.4%), and abdominal pain (n=172; 20.7%), which were mild/moderate throughout the disease and resolved during follow-up. One-third of patients exhibited liver injury. Non-severe COVID-19 was associated with ≥2 GI symptoms upon admission (OR 0.679; 95% CI 0.464-0.995; p=0.046) or diarrhoea during hospitalization (OR 0.531; 95% CI 0.328-0.860; p=0.009). Multivariate analysis revealed that worse hospital outcomes were not independently associated with liver injury or GI symptoms.
Keywords: COVID-19; complicaciones gastrointestinales; gastrointestinal complications; gastrointestinal symptoms; hepatitis; hospitalización; hospitalization; síntomas gastrointestinales.