tetano
Editor, Senior Moderator
Gac Med Mex
. 2024;160(2):128-135.
doi: 10.24875/GMM.M24000878. Contribution of memory T cells to the generation of long-lasting immunity against COVID-19
Alejandro Torres-Flores[SUP] 1 2 [/SUP], Isabel Wong-Baeza[SUP] 2 [/SUP], Constantino López-Macías[SUP] 1 [/SUP]
Affiliations
in English, Spanish
Humans are exposed every day to innumerable external stimuli, both environmental and microbial. Immunological memory recalls each specific stimulus and mounts a secondary response that is faster and of a larger magnitude than the primary response; this process constitutes the basis for vaccine development. The COVID-19 pandemic offers a unique opportunity to study the development of immune memory against an emergent microorganism. Memory T cells have an important role in the resolution of COVID-19, and they are key pillars of immunological memory. In this review, we summarize the main findings regarding anti-SARS-CoV-2 memory T cells after infection, after vaccination, and after the combination of these two events ("hybrid immunity"), and analyze how these cells can contribute to long-term protection against the infection with SARS-CoV-2 variants.
Keywords: Células T; Immunological memory; Memoria inmunológica; SARS-CoV-2; T cells.
. 2024;160(2):128-135.
doi: 10.24875/GMM.M24000878. Contribution of memory T cells to the generation of long-lasting immunity against COVID-19
Alejandro Torres-Flores[SUP] 1 2 [/SUP], Isabel Wong-Baeza[SUP] 2 [/SUP], Constantino López-Macías[SUP] 1 [/SUP]
Affiliations
- PMID: 39116861
- DOI: 10.24875/GMM.M24000878
in English, Spanish
Humans are exposed every day to innumerable external stimuli, both environmental and microbial. Immunological memory recalls each specific stimulus and mounts a secondary response that is faster and of a larger magnitude than the primary response; this process constitutes the basis for vaccine development. The COVID-19 pandemic offers a unique opportunity to study the development of immune memory against an emergent microorganism. Memory T cells have an important role in the resolution of COVID-19, and they are key pillars of immunological memory. In this review, we summarize the main findings regarding anti-SARS-CoV-2 memory T cells after infection, after vaccination, and after the combination of these two events ("hybrid immunity"), and analyze how these cells can contribute to long-term protection against the infection with SARS-CoV-2 variants.
Keywords: Células T; Immunological memory; Memoria inmunológica; SARS-CoV-2; T cells.