tetano
Editor, Senior Moderator
Future Microbiol
. 2021 Jan 19.
doi: 10.2217/fmb-2020-0286. Online ahead of print.
Review of the use of nasal and oral antiseptics during a global pandemic
Christopher Stathis[SUP] 1 [/SUP], Nikolas Victoria[SUP] 1 [/SUP], Kristin Loomis[SUP] 1 [/SUP], Shaun A Nguyen[SUP] 2 [/SUP], Maren Eggers[SUP] 3 [/SUP], Edward Septimus[SUP] 4 [/SUP], Nasia Safdar[SUP] 5 [/SUP]
Affiliations
Abstract
A review of nasal sprays and gargles with antiviral properties suggests that a number of commonly used antiseptics including povidone-iodine, Listerine[SUP]?[/SUP], iota-carrageenan and chlorhexidine should be studied in clinical trials to mitigate both the progression and transmission of severe acute respiratory syndrome coronavirus 2. Several of these antiseptics have demonstrated the ability to cut the viral load of severe acute respiratory syndrome coronavirus 2 by 3-4 log[SUB]10[/SUB] in 15-30 s in vitro. In addition, hypertonic saline targets viral replication by increasing hypochlorous acid inside the cell. A number of clinical trials are in process to study these interventions both for prevention of transmission, prophylaxis after exposure, and to diminish progression by reduction of viral load in the early stages of infection.
Keywords: COVID-19; SARS-CoV-2; chlorhexidine; hydrogen peroxide; hypertonic saline; iota-carrageenan; nasal spray; oral rinse; povidone-iodine; respiratory infections.
. 2021 Jan 19.
doi: 10.2217/fmb-2020-0286. Online ahead of print.
Review of the use of nasal and oral antiseptics during a global pandemic
Christopher Stathis[SUP] 1 [/SUP], Nikolas Victoria[SUP] 1 [/SUP], Kristin Loomis[SUP] 1 [/SUP], Shaun A Nguyen[SUP] 2 [/SUP], Maren Eggers[SUP] 3 [/SUP], Edward Septimus[SUP] 4 [/SUP], Nasia Safdar[SUP] 5 [/SUP]
Affiliations
- PMID: 33464122
- DOI: 10.2217/fmb-2020-0286
Abstract
A review of nasal sprays and gargles with antiviral properties suggests that a number of commonly used antiseptics including povidone-iodine, Listerine[SUP]?[/SUP], iota-carrageenan and chlorhexidine should be studied in clinical trials to mitigate both the progression and transmission of severe acute respiratory syndrome coronavirus 2. Several of these antiseptics have demonstrated the ability to cut the viral load of severe acute respiratory syndrome coronavirus 2 by 3-4 log[SUB]10[/SUB] in 15-30 s in vitro. In addition, hypertonic saline targets viral replication by increasing hypochlorous acid inside the cell. A number of clinical trials are in process to study these interventions both for prevention of transmission, prophylaxis after exposure, and to diminish progression by reduction of viral load in the early stages of infection.
Keywords: COVID-19; SARS-CoV-2; chlorhexidine; hydrogen peroxide; hypertonic saline; iota-carrageenan; nasal spray; oral rinse; povidone-iodine; respiratory infections.