tetano
Editor, Senior Moderator
Immunol Rev. 2020 May;295(1):140-166. doi: 10.1111/imr.12851.
Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism.
Bahadoran A[SUP]1[/SUP], Bezavada L[SUP]1[/SUP], Smallwood HS[SUP]1[/SUP].
Author information
Abstract
Recent studies support the notion that glycolysis and oxidative phosphorylation are rheostats in immune cells whose bioenergetics have functional outputs in terms of their biology. Specific intrinsic and extrinsic molecular factors function as molecular potentiometers to adjust and control glycolytic to respiratory power output. In many cases, these potentiometers are used by influenza viruses and immune cells to support pathogenesis and the host immune response, respectively. Influenza virus infects the respiratory tract, providing a specific environmental niche, while immune cells encounter variable nutrient concentrations as they migrate in response to infection. Immune cell subsets have distinct metabolic programs that adjust to meet energetic and biosynthetic requirements to support effector functions, differentiation, and longevity in their ever-changing microenvironments. This review details how influenza coopts the host cell for metabolic reprogramming and describes the overlap of these regulatory controls in immune cells whose function and fate are dictated by metabolism. These details are contextualized with emerging evidence of the consequences of influenza-induced changes in metabolic homeostasis on disease progression.
? 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:
Immunometabolism; Influenza; host pathogen; immune response; metabolism; viral infection; virus
PMID:32320072DOI:10.1111/imr.12851
Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism.
Bahadoran A[SUP]1[/SUP], Bezavada L[SUP]1[/SUP], Smallwood HS[SUP]1[/SUP].
Author information
Abstract
Recent studies support the notion that glycolysis and oxidative phosphorylation are rheostats in immune cells whose bioenergetics have functional outputs in terms of their biology. Specific intrinsic and extrinsic molecular factors function as molecular potentiometers to adjust and control glycolytic to respiratory power output. In many cases, these potentiometers are used by influenza viruses and immune cells to support pathogenesis and the host immune response, respectively. Influenza virus infects the respiratory tract, providing a specific environmental niche, while immune cells encounter variable nutrient concentrations as they migrate in response to infection. Immune cell subsets have distinct metabolic programs that adjust to meet energetic and biosynthetic requirements to support effector functions, differentiation, and longevity in their ever-changing microenvironments. This review details how influenza coopts the host cell for metabolic reprogramming and describes the overlap of these regulatory controls in immune cells whose function and fate are dictated by metabolism. These details are contextualized with emerging evidence of the consequences of influenza-induced changes in metabolic homeostasis on disease progression.
? 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:
Immunometabolism; Influenza; host pathogen; immune response; metabolism; viral infection; virus
PMID:32320072DOI:10.1111/imr.12851