tetano
Editor, Senior Moderator
Front Public Health
. 2026 Feb 23:14:1764471.
doi: 10.3389/fpubh.2026.1764471. eCollection 2026.
Preemptive rapid antigen test as an emergency measure during coronavirus disease 2019 outbreaks
Yaping Pan[SUP] 1 [/SUP], Yong Liu[SUP] 1 [/SUP], Ye Jiang[SUP] 1 [/SUP], Jin Cai[SUP] 1 [/SUP]
Affiliations
Background: We acknowledge that the rapid antigen test (RAT) has several advantages, including faster results, cost-effectiveness, and suitability for on-site self-testing. However, there is still controversy regarding the performance of the RAT for coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate RAT screening in a COVID-19 outbreak situation.
Methods: In this study, we developed a preemptive testing model in which a RAT was immediately followed by reverse transcriptase polymerase chain reaction (RT-PCR) during a single screening in a high-density community outbreak to rapidly prevent transmission. The RAT and RT-PCR were performed using the Flowflex[SUP]™[/SUP] SARS-CoV-2 Antigen Test Kit and the SARS-CoV-2 Nucleic Acid Test Kit, respectively. Furthermore, we retrospectively investigated diagnostic data from a total of 813 participants. Then, we analyzed sensitivity and specificity using RT-PCR as the reference method. In addition, we compared our data with those from another published study involving serial screening using the chi-squared test, in which 541 samples were analyzed.
Results: Our study showed that the sensitivity and specificity of the RAT were 0.82 and 1.00, respectively. We found a slightly higher false-negative rate, corresponding to decreased sensitivity, in our data compared to the previous study; however, the difference was not statistically significant. In addition, there was no statistically significant difference in the false-positive rate, corresponding to specificity, between the two studies.
Conclusion: The current results indicate that a RAT with a single screening does not pose an additional risk of inaccurate diagnosis of COVID-19 compared to serial screening. The strategy of a preemptive RAT might be an effective emergency measure to prevent COVID-19 transmission at an early stage of an outbreak.
Keywords: acute respiratory infectious diseases; coronavirus disease 2019; emergency measures; outbreaks; rapid antigen test; reverse transcriptase polymerase chain reaction.
. 2026 Feb 23:14:1764471.
doi: 10.3389/fpubh.2026.1764471. eCollection 2026.
Preemptive rapid antigen test as an emergency measure during coronavirus disease 2019 outbreaks
Yaping Pan[SUP] 1 [/SUP], Yong Liu[SUP] 1 [/SUP], Ye Jiang[SUP] 1 [/SUP], Jin Cai[SUP] 1 [/SUP]
Affiliations
- PMID: 41810307
- PMCID: PMC12968284
- DOI: 10.3389/fpubh.2026.1764471
Background: We acknowledge that the rapid antigen test (RAT) has several advantages, including faster results, cost-effectiveness, and suitability for on-site self-testing. However, there is still controversy regarding the performance of the RAT for coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate RAT screening in a COVID-19 outbreak situation.
Methods: In this study, we developed a preemptive testing model in which a RAT was immediately followed by reverse transcriptase polymerase chain reaction (RT-PCR) during a single screening in a high-density community outbreak to rapidly prevent transmission. The RAT and RT-PCR were performed using the Flowflex[SUP]™[/SUP] SARS-CoV-2 Antigen Test Kit and the SARS-CoV-2 Nucleic Acid Test Kit, respectively. Furthermore, we retrospectively investigated diagnostic data from a total of 813 participants. Then, we analyzed sensitivity and specificity using RT-PCR as the reference method. In addition, we compared our data with those from another published study involving serial screening using the chi-squared test, in which 541 samples were analyzed.
Results: Our study showed that the sensitivity and specificity of the RAT were 0.82 and 1.00, respectively. We found a slightly higher false-negative rate, corresponding to decreased sensitivity, in our data compared to the previous study; however, the difference was not statistically significant. In addition, there was no statistically significant difference in the false-positive rate, corresponding to specificity, between the two studies.
Conclusion: The current results indicate that a RAT with a single screening does not pose an additional risk of inaccurate diagnosis of COVID-19 compared to serial screening. The strategy of a preemptive RAT might be an effective emergency measure to prevent COVID-19 transmission at an early stage of an outbreak.
Keywords: acute respiratory infectious diseases; coronavirus disease 2019; emergency measures; outbreaks; rapid antigen test; reverse transcriptase polymerase chain reaction.