tetano
Editor, Senior Moderator
Front Public Health
. 2023 Mar 2;11:1095202.
doi: 10.3389/fpubh.2023.1095202. eCollection 2023.
Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021
Jose Arturo Molina-Mora[SUP] 1 [/SUP], Jhonnatan Reales-González[SUP] 2 [/SUP], Erwin Camacho[SUP] 3 [/SUP], Francisco Duarte-Martínez[SUP] 4 [/SUP], Pablo Tsukayama[SUP] 5 [/SUP], Claudio Soto-Garita[SUP] 4 [/SUP], Hebleen Brenes[SUP] 4 [/SUP], Estela Cordero-Laurent[SUP] 4 [/SUP], Andrea Ribeiro Dos Santos[SUP] 6 [/SUP], Cláudio Guedes Salgado[SUP] 6 [/SUP], Caio Santos Silva[SUP] 6 [/SUP], Jorge Santana de Souza[SUP] 7 [/SUP], Gisele Nunes[SUP] 8 [/SUP], Tatianne Negri[SUP] 8 [/SUP], Amanda Vidal[SUP] 8 [/SUP], Renato Oliveira[SUP] 8 [/SUP], Guilherme Oliveira[SUP] 8 [/SUP], José Esteban Muñoz-Medina[SUP] 9 [/SUP], Angel Gustavo Salas-Lais[SUP] 9 [/SUP], Guadalupe Mireles-Rivera[SUP] 10 [/SUP], Ezequiel Sosa[SUP] 11 12 [/SUP], Adrián Turjanski[SUP] 11 12 [/SUP], María Cecilia Monzani[SUP] 12 13 [/SUP], Mauricio G Carobene[SUP] 12 13 [/SUP], Federico Remes Lenicov[SUP] 12 13 [/SUP], Gustavo Schottlender[SUP] 11 [/SUP], Darío A Fernández Do Porto[SUP] 11 [/SUP], Jan Frederik Kreuze[SUP] 14 [/SUP], Luisa Sacristán[SUP] 15 [/SUP], Marcela Guevara-Suarez[SUP] 15 [/SUP], Marco Cristancho[SUP] 15 [/SUP], Rebeca Campos-Sánchez[SUP] 16 [/SUP], Alfredo Herrera-Estrella[SUP] 10 [/SUP]
Affiliations
Abstract
Latin America is one of the regions in which the COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 million deaths until June 2022. Since this region is ecologically diverse and is affected by enormous social inequalities, efforts to identify genomic patterns of the circulating SARS-CoV-2 genotypes are necessary for the suitable management of the pandemic. To contribute to the genomic surveillance of the SARS-CoV-2 in Latin America, we extended the number of SARS-CoV-2 genomes available from the region by sequencing and analyzing the viral genome from COVID-19 patients from seven countries (Argentina, Brazil, Costa Rica, Colombia, Mexico, Bolivia, and Peru). Subsequently, we analyzed the genomes circulating mainly during 2021 including records from GISAID database from Latin America. A total of 1,534 genome sequences were generated from seven countries, demonstrating the laboratory and bioinformatics capabilities for genomic surveillance of pathogens that have been developed locally. For Latin America, patterns regarding several variants associated with multiple re-introductions, a relatively low percentage of sequenced samples, as well as an increment in the mutation frequency since the beginning of the pandemic, are in line with worldwide data. Besides, some variants of concern (VOC) and variants of interest (VOI) such as Gamma, Mu and Lambda, and at least 83 other lineages have predominated locally with a country-specific enrichments. This work has contributed to the understanding of the dynamics of the pandemic in Latin America as part of the local and international efforts to achieve timely genomic surveillance of SARS-CoV-2.
Keywords: CABANA; COVID-19; Latin America; SARS-CoV-2; coronavirus; genomic surveillance.
. 2023 Mar 2;11:1095202.
doi: 10.3389/fpubh.2023.1095202. eCollection 2023.
Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021
Jose Arturo Molina-Mora[SUP] 1 [/SUP], Jhonnatan Reales-González[SUP] 2 [/SUP], Erwin Camacho[SUP] 3 [/SUP], Francisco Duarte-Martínez[SUP] 4 [/SUP], Pablo Tsukayama[SUP] 5 [/SUP], Claudio Soto-Garita[SUP] 4 [/SUP], Hebleen Brenes[SUP] 4 [/SUP], Estela Cordero-Laurent[SUP] 4 [/SUP], Andrea Ribeiro Dos Santos[SUP] 6 [/SUP], Cláudio Guedes Salgado[SUP] 6 [/SUP], Caio Santos Silva[SUP] 6 [/SUP], Jorge Santana de Souza[SUP] 7 [/SUP], Gisele Nunes[SUP] 8 [/SUP], Tatianne Negri[SUP] 8 [/SUP], Amanda Vidal[SUP] 8 [/SUP], Renato Oliveira[SUP] 8 [/SUP], Guilherme Oliveira[SUP] 8 [/SUP], José Esteban Muñoz-Medina[SUP] 9 [/SUP], Angel Gustavo Salas-Lais[SUP] 9 [/SUP], Guadalupe Mireles-Rivera[SUP] 10 [/SUP], Ezequiel Sosa[SUP] 11 12 [/SUP], Adrián Turjanski[SUP] 11 12 [/SUP], María Cecilia Monzani[SUP] 12 13 [/SUP], Mauricio G Carobene[SUP] 12 13 [/SUP], Federico Remes Lenicov[SUP] 12 13 [/SUP], Gustavo Schottlender[SUP] 11 [/SUP], Darío A Fernández Do Porto[SUP] 11 [/SUP], Jan Frederik Kreuze[SUP] 14 [/SUP], Luisa Sacristán[SUP] 15 [/SUP], Marcela Guevara-Suarez[SUP] 15 [/SUP], Marco Cristancho[SUP] 15 [/SUP], Rebeca Campos-Sánchez[SUP] 16 [/SUP], Alfredo Herrera-Estrella[SUP] 10 [/SUP]
Affiliations
- PMID: 36935725
- PMCID: PMC10018007
- DOI: 10.3389/fpubh.2023.1095202
Abstract
Latin America is one of the regions in which the COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 million deaths until June 2022. Since this region is ecologically diverse and is affected by enormous social inequalities, efforts to identify genomic patterns of the circulating SARS-CoV-2 genotypes are necessary for the suitable management of the pandemic. To contribute to the genomic surveillance of the SARS-CoV-2 in Latin America, we extended the number of SARS-CoV-2 genomes available from the region by sequencing and analyzing the viral genome from COVID-19 patients from seven countries (Argentina, Brazil, Costa Rica, Colombia, Mexico, Bolivia, and Peru). Subsequently, we analyzed the genomes circulating mainly during 2021 including records from GISAID database from Latin America. A total of 1,534 genome sequences were generated from seven countries, demonstrating the laboratory and bioinformatics capabilities for genomic surveillance of pathogens that have been developed locally. For Latin America, patterns regarding several variants associated with multiple re-introductions, a relatively low percentage of sequenced samples, as well as an increment in the mutation frequency since the beginning of the pandemic, are in line with worldwide data. Besides, some variants of concern (VOC) and variants of interest (VOI) such as Gamma, Mu and Lambda, and at least 83 other lineages have predominated locally with a country-specific enrichments. This work has contributed to the understanding of the dynamics of the pandemic in Latin America as part of the local and international efforts to achieve timely genomic surveillance of SARS-CoV-2.
Keywords: CABANA; COVID-19; Latin America; SARS-CoV-2; coronavirus; genomic surveillance.