tetano
Editor, Senior Moderator
Front Public Health
. 2021 Dec 14;9:778340.
doi: 10.3389/fpubh.2021.778340. eCollection 2021.
Liver Injury and Elevated Levels of Interleukins, Interleukin-2 Receptor, and Interleukin-6 Predict the Severity in Patients With COVID-19
Kuan Luo[SUP] 1 2 3 [/SUP], Yongfeng Chen[SUP] 2 4 [/SUP], Junjie Yang[SUP] 5 [/SUP], Quan Tao[SUP] 2 6 [/SUP], Min Luo[SUP] 7 8 9 [/SUP]
Affiliations
Abstract
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, and the WHO declared it a pandemic on March 11, 2020. Clinical characteristics and epidemiology features of patients infected with SARS-CoV-2 have been explored in the previous study. However, little is known about the combinative association of liver dysfunction and abnormal interleukins (ILs) in severe patients with COVID-19. This study was designed to estimate whether liver dysfunction and abnormal ILs could predict the severity of COVID-19. This study integrated liver function data and ILs data in patients with COVID-19 and found that liver injury and two ILs, interleukin-2 receptor (IL-2R) and interleukin-6 (IL-6), were closely related to the prognosis of patients with COVID-19. This study may give more exact information to clinicians about the prognosis of patients with COVID-19. In addition, this correlational study between liver disorder and ILs may provide a new vision to diagnosis and treatment in patients.
Keywords: COVID-19; IL-2R; IL-6; liver injury; prognosis.
. 2021 Dec 14;9:778340.
doi: 10.3389/fpubh.2021.778340. eCollection 2021.
Liver Injury and Elevated Levels of Interleukins, Interleukin-2 Receptor, and Interleukin-6 Predict the Severity in Patients With COVID-19
Kuan Luo[SUP] 1 2 3 [/SUP], Yongfeng Chen[SUP] 2 4 [/SUP], Junjie Yang[SUP] 5 [/SUP], Quan Tao[SUP] 2 6 [/SUP], Min Luo[SUP] 7 8 9 [/SUP]
Affiliations
- PMID: 34970527
- PMCID: PMC8713698
- DOI: 10.3389/fpubh.2021.778340
Abstract
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, and the WHO declared it a pandemic on March 11, 2020. Clinical characteristics and epidemiology features of patients infected with SARS-CoV-2 have been explored in the previous study. However, little is known about the combinative association of liver dysfunction and abnormal interleukins (ILs) in severe patients with COVID-19. This study was designed to estimate whether liver dysfunction and abnormal ILs could predict the severity of COVID-19. This study integrated liver function data and ILs data in patients with COVID-19 and found that liver injury and two ILs, interleukin-2 receptor (IL-2R) and interleukin-6 (IL-6), were closely related to the prognosis of patients with COVID-19. This study may give more exact information to clinicians about the prognosis of patients with COVID-19. In addition, this correlational study between liver disorder and ILs may provide a new vision to diagnosis and treatment in patients.
Keywords: COVID-19; IL-2R; IL-6; liver injury; prognosis.