tetano
Editor, Senior Moderator
Front Public Health
. 2025 Jan 29:12:1390951.
doi: 10.3389/fpubh.2024.1390951. eCollection 2024. COVID-19 vaccination: challenges in the pediatric population
Alice Nicoleta Azoicai[SUP] #[/SUP][SUP] 1 [/SUP], Ingrith Miron[SUP] #[/SUP][SUP] 1 [/SUP], Ancuta Lupu[SUP] #[/SUP][SUP] 1 [/SUP], Monica Mihaela Alexoae[SUP] #[/SUP][SUP] 1 [/SUP], Iuliana Magdalena Starcea[SUP] #[/SUP][SUP] 1 [/SUP], Mirabela Alecsa[SUP] #[/SUP][SUP] 1 [/SUP], Vasile Valeriu Lupu[SUP] #[/SUP][SUP] 1 [/SUP], Ciprian Danielescu[SUP] #[/SUP][SUP] 2 [/SUP], Alin Horatiu Nedelcu[SUP] #[/SUP][SUP] 2 [/SUP], Delia Lidia Salaru[SUP] #[/SUP][SUP] 2 [/SUP], Felicia Dragan[SUP] #[/SUP][SUP] 3 [/SUP], Ileana Ioniuc[SUP] #[/SUP][SUP] 1 [/SUP]
Affiliations
Vaccination is considered to be one of the most effective means of protecting individuals and populations from the risks associated with exposure to various pathogens. The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affected people of all ages worldwide. In response, several pharmaceutical companies rapidly leveraged their resources to develop vaccines within a very short period of time, leading to the introduction of new, improved, and combination vaccines for community-wide immunization. This review aims to provide a summary of the available literature on the efficacy and safety of COVID-19 vaccines in the pediatric population ranging from 0 to 18 years. An analysis of recent published studies reveals that the majority of clinical trials have reported a sustained immune response following COVID-19 vaccination in children across various age groups worldwide. The majority of the authors highlighted the effectiveness and safety of immunization schedules in children and adolescents. The population-level efficacy of this vaccination remains to be determined, provided that the benefits outweigh the potential risks. Long-term side effects must still be monitored to enable the development of safer and more effective vaccines for future pandemics.
Keywords: COVID-19; SARS-CoV-2; children; efficacy; safety; vaccine.
. 2025 Jan 29:12:1390951.
doi: 10.3389/fpubh.2024.1390951. eCollection 2024. COVID-19 vaccination: challenges in the pediatric population
Alice Nicoleta Azoicai[SUP] #[/SUP][SUP] 1 [/SUP], Ingrith Miron[SUP] #[/SUP][SUP] 1 [/SUP], Ancuta Lupu[SUP] #[/SUP][SUP] 1 [/SUP], Monica Mihaela Alexoae[SUP] #[/SUP][SUP] 1 [/SUP], Iuliana Magdalena Starcea[SUP] #[/SUP][SUP] 1 [/SUP], Mirabela Alecsa[SUP] #[/SUP][SUP] 1 [/SUP], Vasile Valeriu Lupu[SUP] #[/SUP][SUP] 1 [/SUP], Ciprian Danielescu[SUP] #[/SUP][SUP] 2 [/SUP], Alin Horatiu Nedelcu[SUP] #[/SUP][SUP] 2 [/SUP], Delia Lidia Salaru[SUP] #[/SUP][SUP] 2 [/SUP], Felicia Dragan[SUP] #[/SUP][SUP] 3 [/SUP], Ileana Ioniuc[SUP] #[/SUP][SUP] 1 [/SUP]
Affiliations
- PMID: 39944570
- PMCID: PMC11813920
- DOI: 10.3389/fpubh.2024.1390951
Vaccination is considered to be one of the most effective means of protecting individuals and populations from the risks associated with exposure to various pathogens. The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affected people of all ages worldwide. In response, several pharmaceutical companies rapidly leveraged their resources to develop vaccines within a very short period of time, leading to the introduction of new, improved, and combination vaccines for community-wide immunization. This review aims to provide a summary of the available literature on the efficacy and safety of COVID-19 vaccines in the pediatric population ranging from 0 to 18 years. An analysis of recent published studies reveals that the majority of clinical trials have reported a sustained immune response following COVID-19 vaccination in children across various age groups worldwide. The majority of the authors highlighted the effectiveness and safety of immunization schedules in children and adolescents. The population-level efficacy of this vaccination remains to be determined, provided that the benefits outweigh the potential risks. Long-term side effects must still be monitored to enable the development of safer and more effective vaccines for future pandemics.
Keywords: COVID-19; SARS-CoV-2; children; efficacy; safety; vaccine.