tetano
Editor, Senior Moderator
Front Pediatr
. 2021 Dec 17;9:756014.
doi: 10.3389/fped.2021.756014. eCollection 2021.
Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
Katrin Knoflach[SUP] 1 [/SUP], Eva Holzapfel[SUP] 1 [/SUP], Timo Roser[SUP] 1 [/SUP], Lieselotte Rudolph[SUP] 2 [/SUP], Marco Paolini[SUP] 3 [/SUP], Maximilian Muenchhoff[SUP] 4 5 [/SUP], Andreas Osterman[SUP] 4 5 [/SUP], Matthias Griese[SUP] 1 6 [/SUP], Matthias Kappler[SUP] 1 [/SUP], Ulrich von Both[SUP] 1 5 [/SUP]
Affiliations
Abstract
Children have been described to show neurological symptoms in acute coronavirus disease 2019 (COVID-19) and multisystemic inflammatory syndrome in children (MIS-C). We present a 2-year-old boy's clinical course of unilateral acute sixth nerve palsy in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Onset of the palsy in the otherwise healthy boy occurred seven days after symptoms attributed to acute infection had subsided respectively 3 weeks after onset of respiratory symptoms. SARS-CoV-2 specific IgG was detected in serum as well as in cerebrospinal fluid. The patient showed a prolonged but self-limiting course with a full recovery after three and a half months. This case illustrates in a detailed chronological sequence that sixth cranial nerve involvement may occur as post-infectious, self-limiting complication of pediatric SARS-CoV-2-infection thus expanding the neurological spectrum of symptoms for children with COVID-19. Clinicians should be aware of the possibility of post-infectious sixth nerve palsy related to SARS-CoV-2-infection particularly in view of recent respiratory tract infection or confirmed cases of SARS-CoV-2-infection amongst the patient's close contacts.
Keywords: COVID-19; SARS-CoV-2; anti-SARS-CoV-2 antibodies; pediatric; sixth cranial nerve palsy.
. 2021 Dec 17;9:756014.
doi: 10.3389/fped.2021.756014. eCollection 2021.
Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
Katrin Knoflach[SUP] 1 [/SUP], Eva Holzapfel[SUP] 1 [/SUP], Timo Roser[SUP] 1 [/SUP], Lieselotte Rudolph[SUP] 2 [/SUP], Marco Paolini[SUP] 3 [/SUP], Maximilian Muenchhoff[SUP] 4 5 [/SUP], Andreas Osterman[SUP] 4 5 [/SUP], Matthias Griese[SUP] 1 6 [/SUP], Matthias Kappler[SUP] 1 [/SUP], Ulrich von Both[SUP] 1 5 [/SUP]
Affiliations
- PMID: 34976891
- PMCID: PMC8718702
- DOI: 10.3389/fped.2021.756014
Abstract
Children have been described to show neurological symptoms in acute coronavirus disease 2019 (COVID-19) and multisystemic inflammatory syndrome in children (MIS-C). We present a 2-year-old boy's clinical course of unilateral acute sixth nerve palsy in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Onset of the palsy in the otherwise healthy boy occurred seven days after symptoms attributed to acute infection had subsided respectively 3 weeks after onset of respiratory symptoms. SARS-CoV-2 specific IgG was detected in serum as well as in cerebrospinal fluid. The patient showed a prolonged but self-limiting course with a full recovery after three and a half months. This case illustrates in a detailed chronological sequence that sixth cranial nerve involvement may occur as post-infectious, self-limiting complication of pediatric SARS-CoV-2-infection thus expanding the neurological spectrum of symptoms for children with COVID-19. Clinicians should be aware of the possibility of post-infectious sixth nerve palsy related to SARS-CoV-2-infection particularly in view of recent respiratory tract infection or confirmed cases of SARS-CoV-2-infection amongst the patient's close contacts.
Keywords: COVID-19; SARS-CoV-2; anti-SARS-CoV-2 antibodies; pediatric; sixth cranial nerve palsy.