tetano
Editor, Senior Moderator
Front Neurol
. 2022 Feb 7;13:731369.
doi: 10.3389/fneur.2022.731369. eCollection 2022.
Case Report: Neurodegenerative Diseases After Severe Acute Respiratory Syndrome Coronavirus 2 Infection, a Report of Three Cases: Creutzfeldt-Jakob Disease, Rapidly Progressive Alzheimer's Disease, and Frontotemporal Dementia
Gabriela Almeida Pimentel[SUP] 1 [/SUP], Thiago Gonçalves Guimarães[SUP] 1 [/SUP], Guilherme Diogo Silva[SUP] 1 [/SUP], Milberto Scaff[SUP] 2 [/SUP]
Affiliations
Abstract
The relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and neurodegenerative diseases is yet to be fully clarified. Rapid worsening and even new-onset cases of those disorders have been reported in association with coronavirus disease 2019 (COVID-19). We describe three cases of neurodegenerative diseases in patients with SARS-CoV-2: a case of Creutzfeldt-Jakob disease during the COVID-19 acute phase, to our knowledge, is the second one described in the literature; a rapidly progressive Alzheimer's Disease; and a patient with frontotemporal dementia, and a quick decline of both cognitive and behavioral domains. This report suggests an association between SARS-CoV-2 infection and a higher probability of developing or accelerating neurodegenerative chronic neurologic conditions. We reinforce the need for a close cognitive follow-up in the aftermath of Sars-Cov2 infection.
Keywords: Alzheimer's disease; COVID-19; Creutzfeldt–Jakob disease; SARS-CoV-2; case report; frontotemporal dementia; neurodegenerative disease.
. 2022 Feb 7;13:731369.
doi: 10.3389/fneur.2022.731369. eCollection 2022.
Case Report: Neurodegenerative Diseases After Severe Acute Respiratory Syndrome Coronavirus 2 Infection, a Report of Three Cases: Creutzfeldt-Jakob Disease, Rapidly Progressive Alzheimer's Disease, and Frontotemporal Dementia
Gabriela Almeida Pimentel[SUP] 1 [/SUP], Thiago Gonçalves Guimarães[SUP] 1 [/SUP], Guilherme Diogo Silva[SUP] 1 [/SUP], Milberto Scaff[SUP] 2 [/SUP]
Affiliations
- PMID: 35197920
- PMCID: PMC8858976
- DOI: 10.3389/fneur.2022.731369
Abstract
The relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and neurodegenerative diseases is yet to be fully clarified. Rapid worsening and even new-onset cases of those disorders have been reported in association with coronavirus disease 2019 (COVID-19). We describe three cases of neurodegenerative diseases in patients with SARS-CoV-2: a case of Creutzfeldt-Jakob disease during the COVID-19 acute phase, to our knowledge, is the second one described in the literature; a rapidly progressive Alzheimer's Disease; and a patient with frontotemporal dementia, and a quick decline of both cognitive and behavioral domains. This report suggests an association between SARS-CoV-2 infection and a higher probability of developing or accelerating neurodegenerative chronic neurologic conditions. We reinforce the need for a close cognitive follow-up in the aftermath of Sars-Cov2 infection.
Keywords: Alzheimer's disease; COVID-19; Creutzfeldt–Jakob disease; SARS-CoV-2; case report; frontotemporal dementia; neurodegenerative disease.
