tetano
Editor, Senior Moderator
Front Neurol
. 2022 Mar 14;13:838222.
doi: 10.3389/fneur.2022.838222. eCollection 2022.
Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
Shirui Wen[SUP] 1 [/SUP], Kailing Huang[SUP] 1 [/SUP], Haoyue Zhu[SUP] 1 [/SUP], Peihong Li[SUP] 1 [/SUP], Luo Zhou[SUP] 1 [/SUP], Li Feng[SUP] 1 [/SUP]
Affiliations
Abstract
Corona Virus Disease 2019 (COVID-19), the novel coronavirus disease, is now a global pandemic. Vaccination can significantly reduce the mortality rate caused by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). There are currently several effective vaccines that have been introduced. Inactivated COVID-19 vaccine is one of these options and is generally considered safe. Neurofascin (NF) plays an important role in keeping the functionality of the node of Ranvier. We report here a rare case of anti-NF186+ chronic inflammatory demyelinating polyneuropathy (CIDP) in a 23-year-old male patient who was vaccinated with inactivated COVID-19 vaccine prior to the onset. This report adds a new possible rare side effect of a COVID-19 vaccine and provides a case for the clinical effectiveness of rituximab (RTX) in patients with anti-NF186+ CIDP.
Keywords: COVID-19; NF186; autoimmune disease; chronic inflammatory demyelinating polyneuropathy (CIDP); inactivated COVID-19 vaccine.
. 2022 Mar 14;13:838222.
doi: 10.3389/fneur.2022.838222. eCollection 2022.
Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
Shirui Wen[SUP] 1 [/SUP], Kailing Huang[SUP] 1 [/SUP], Haoyue Zhu[SUP] 1 [/SUP], Peihong Li[SUP] 1 [/SUP], Luo Zhou[SUP] 1 [/SUP], Li Feng[SUP] 1 [/SUP]
Affiliations
- PMID: 35359644
- PMCID: PMC8964034
- DOI: 10.3389/fneur.2022.838222
Abstract
Corona Virus Disease 2019 (COVID-19), the novel coronavirus disease, is now a global pandemic. Vaccination can significantly reduce the mortality rate caused by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). There are currently several effective vaccines that have been introduced. Inactivated COVID-19 vaccine is one of these options and is generally considered safe. Neurofascin (NF) plays an important role in keeping the functionality of the node of Ranvier. We report here a rare case of anti-NF186+ chronic inflammatory demyelinating polyneuropathy (CIDP) in a 23-year-old male patient who was vaccinated with inactivated COVID-19 vaccine prior to the onset. This report adds a new possible rare side effect of a COVID-19 vaccine and provides a case for the clinical effectiveness of rituximab (RTX) in patients with anti-NF186+ CIDP.
Keywords: COVID-19; NF186; autoimmune disease; chronic inflammatory demyelinating polyneuropathy (CIDP); inactivated COVID-19 vaccine.