tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2022 Mar 18;9:823837.
doi: 10.3389/fmed.2022.823837. eCollection 2022.
Patients With Suspected Severe Adverse Reactions to COVID-19 Vaccination Admitted to Intensive Care Unit: A Case Report
Denise Battaglini[SUP] 1 2 [/SUP], Lorenzo Ball[SUP] 1 3 [/SUP], Chiara Robba[SUP] 1 3 [/SUP], Simona Maiani[SUP] 1 [/SUP], Iole Brunetti[SUP] 1 [/SUP], Luana Benedetti[SUP] 4 5 [/SUP], Lucio Castellan[SUP] 6 [/SUP], Gianluigi Zona[SUP] 4 7 [/SUP], Giampaola Pesce[SUP] 8 9 [/SUP], Patricia R M Rocco[SUP] 10 [/SUP], Paolo Pelosi[SUP] 1 3 [/SUP]
Affiliations
Abstract
Background: Several cases of adverse reactions following vaccination for coronavirus disease 2019 (COVID-19) with adenoviral vector vaccines or mRNA-based vaccines have been reported to date. The underlying syndrome has been named "vaccine-induced immune thrombotic thrombocytopenia" (VITT) or "thrombosis with thrombocytopenia syndrome (TTS)" with different clinical manifestations.
Methods: We report the clinical course of five patients who had severe adverse reactions to COVID-19 vaccines, either with VITT/TTS, abdominal or pulmonary thrombosis after adenoviral vaccines, or Stevens' Johnson syndrome because of mRNA vaccination, all of whom required admission to the intensive care unit (ICU).
Conclusions: All patients with severe or life-threatening suspected reaction to different types of COVID-19 vaccination required ICU admission. A prompt evaluation of early symptoms and individualized clinical management is needed to improve outcomes.
Keywords: COVID-19; coronavirus disease 2019; thrombosis with thrombocytopenia syndrome; vaccine-induced immune thrombotic thrombocytopenia; vaccines.
. 2022 Mar 18;9:823837.
doi: 10.3389/fmed.2022.823837. eCollection 2022.
Patients With Suspected Severe Adverse Reactions to COVID-19 Vaccination Admitted to Intensive Care Unit: A Case Report
Denise Battaglini[SUP] 1 2 [/SUP], Lorenzo Ball[SUP] 1 3 [/SUP], Chiara Robba[SUP] 1 3 [/SUP], Simona Maiani[SUP] 1 [/SUP], Iole Brunetti[SUP] 1 [/SUP], Luana Benedetti[SUP] 4 5 [/SUP], Lucio Castellan[SUP] 6 [/SUP], Gianluigi Zona[SUP] 4 7 [/SUP], Giampaola Pesce[SUP] 8 9 [/SUP], Patricia R M Rocco[SUP] 10 [/SUP], Paolo Pelosi[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35372434
- PMCID: PMC8972056
- DOI: 10.3389/fmed.2022.823837
Abstract
Background: Several cases of adverse reactions following vaccination for coronavirus disease 2019 (COVID-19) with adenoviral vector vaccines or mRNA-based vaccines have been reported to date. The underlying syndrome has been named "vaccine-induced immune thrombotic thrombocytopenia" (VITT) or "thrombosis with thrombocytopenia syndrome (TTS)" with different clinical manifestations.
Methods: We report the clinical course of five patients who had severe adverse reactions to COVID-19 vaccines, either with VITT/TTS, abdominal or pulmonary thrombosis after adenoviral vaccines, or Stevens' Johnson syndrome because of mRNA vaccination, all of whom required admission to the intensive care unit (ICU).
Conclusions: All patients with severe or life-threatening suspected reaction to different types of COVID-19 vaccination required ICU admission. A prompt evaluation of early symptoms and individualized clinical management is needed to improve outcomes.
Keywords: COVID-19; coronavirus disease 2019; thrombosis with thrombocytopenia syndrome; vaccine-induced immune thrombotic thrombocytopenia; vaccines.
