tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2022 Jan 21;8:768261.
doi: 10.3389/fmed.2021.768261. eCollection 2021.
Lung Ultrasound Signs and Their Correlation With Clinical Symptoms in COVID-19 Pregnant Women: The "PINK-CO" Observational Study
Luigi Vetrugno[SUP] 1 2 [/SUP], Alessia Sala[SUP] 1 3 [/SUP], Daniele Orso[SUP] 1 2 [/SUP], Francesco Meroi[SUP] 1 2 [/SUP], Sebastiano Fabbro[SUP] 1 [/SUP], Enrico Boero[SUP] 4 [/SUP], Francesca Valent[SUP] 5 [/SUP], Gianmaria Cammarota[SUP] 6 [/SUP], Stefano Restaino[SUP] 3 [/SUP], Giuseppe Vizzielli[SUP] 3 [/SUP], Rossano Girometti[SUP] 1 7 [/SUP], Maria Merelli[SUP] 8 [/SUP], Carlo Tascini[SUP] 1 8 [/SUP], Tiziana Bove[SUP] 1 2 [/SUP], Lorenza Driul[SUP] 1 3 [/SUP], PINK-CO study investigators
Collaborators, Affiliations
Abstract
Objective: To analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients.
Design: A single-center observational retrospective study from October 31, 2020 to March 31, 2021.
Setting: Department of Ob/Gyn at the University-Hospital of Udine, Italy.
Participants: Pregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19.
Exposure: Lung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations.
Main outcome: Reporting LUS findings and LUS score characteristics.
Results: Symptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, p < 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; p = 0.011), interleukin-6 (p = 0.013), and pro-adrenomedullin (p = 0.02), and inversely related to arterial oxygen saturation (p = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0).
Conclusion: Lung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge.
Study registration: ClinicalTrials.gov, NCT04823234. Registered on March 29, 2021.
Keywords: COVID-19; SARS-CoV-2; lung ultrasound; lung ultrasound score (LUS); pregnant women.
. 2022 Jan 21;8:768261.
doi: 10.3389/fmed.2021.768261. eCollection 2021.
Lung Ultrasound Signs and Their Correlation With Clinical Symptoms in COVID-19 Pregnant Women: The "PINK-CO" Observational Study
Luigi Vetrugno[SUP] 1 2 [/SUP], Alessia Sala[SUP] 1 3 [/SUP], Daniele Orso[SUP] 1 2 [/SUP], Francesco Meroi[SUP] 1 2 [/SUP], Sebastiano Fabbro[SUP] 1 [/SUP], Enrico Boero[SUP] 4 [/SUP], Francesca Valent[SUP] 5 [/SUP], Gianmaria Cammarota[SUP] 6 [/SUP], Stefano Restaino[SUP] 3 [/SUP], Giuseppe Vizzielli[SUP] 3 [/SUP], Rossano Girometti[SUP] 1 7 [/SUP], Maria Merelli[SUP] 8 [/SUP], Carlo Tascini[SUP] 1 8 [/SUP], Tiziana Bove[SUP] 1 2 [/SUP], Lorenza Driul[SUP] 1 3 [/SUP], PINK-CO study investigators
Collaborators, Affiliations
- PMID: 35127744
- PMCID: PMC8814327
- DOI: 10.3389/fmed.2021.768261
Abstract
Objective: To analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients.
Design: A single-center observational retrospective study from October 31, 2020 to March 31, 2021.
Setting: Department of Ob/Gyn at the University-Hospital of Udine, Italy.
Participants: Pregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19.
Exposure: Lung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations.
Main outcome: Reporting LUS findings and LUS score characteristics.
Results: Symptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, p < 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; p = 0.011), interleukin-6 (p = 0.013), and pro-adrenomedullin (p = 0.02), and inversely related to arterial oxygen saturation (p = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0).
Conclusion: Lung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge.
Study registration: ClinicalTrials.gov, NCT04823234. Registered on March 29, 2021.
Keywords: COVID-19; SARS-CoV-2; lung ultrasound; lung ultrasound score (LUS); pregnant women.