tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2020 Nov 4;7:579406.
doi: 10.3389/fmed.2020.579406. eCollection 2020.
Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China
Xuejiao Liao[SUP] 1 [/SUP], Jiaye Liu[SUP] 1 [/SUP], Ziyi He[SUP] 1 [/SUP], Ming Hu[SUP] 1 [/SUP], Tongyang Xiao[SUP] 1 [/SUP], Lanlan Wei[SUP] 1 [/SUP], Qiue Cai[SUP] 1 [/SUP], Haiyan Wang[SUP] 1 [/SUP], Qing He[SUP] 1 [/SUP], Lei Liu[SUP] 1 [/SUP], Zheng Zhang[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: To investigate the clinical characteristics of children with coronavirus disease 2019 (COVID-19) and identify the occurrence of viral shedding of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during follow-up. Methods: We retrospectively retrieved data from pediatric patients with COVID-19 from the Shenzhen Third People's Hospital in China. The dynamics of SARS-CoV-2 and antibodies against SARS-CoV-2 were analyzed during hospitalization and after discharge. Results: From January 23 to March 15, 2020, a total of 28 pediatric patients were diagnosed with COVID-19 and were followed for at least 1 month. The median age was 7 years (IQR 3.5-10) and none of the children progressed to severe COVID-19 during hospitalization. Ten patients tested positive for SARS-CoV-2 1 month after discharge while four patients tested positive during the 2nd month after discharge. Only three of 12 children showed detectable immunoglobulin-M (IgM) on day 5, 18, and 21 after illness onset, respectively. Conclusions: COVID-19 disease was relatively mild among children while a number did test positive after discharge from the hospital. Public health initiatives should thus adapt control measures targeted toward children.
Keywords: antibody; clinical features; coronavirus disease 2019 (COVID-19); pediatric; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2020 Nov 4;7:579406.
doi: 10.3389/fmed.2020.579406. eCollection 2020.
Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China
Xuejiao Liao[SUP] 1 [/SUP], Jiaye Liu[SUP] 1 [/SUP], Ziyi He[SUP] 1 [/SUP], Ming Hu[SUP] 1 [/SUP], Tongyang Xiao[SUP] 1 [/SUP], Lanlan Wei[SUP] 1 [/SUP], Qiue Cai[SUP] 1 [/SUP], Haiyan Wang[SUP] 1 [/SUP], Qing He[SUP] 1 [/SUP], Lei Liu[SUP] 1 [/SUP], Zheng Zhang[SUP] 2 [/SUP]
Affiliations
- PMID: 33251230
- PMCID: PMC7672180
- DOI: 10.3389/fmed.2020.579406
Abstract
Objective: To investigate the clinical characteristics of children with coronavirus disease 2019 (COVID-19) and identify the occurrence of viral shedding of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during follow-up. Methods: We retrospectively retrieved data from pediatric patients with COVID-19 from the Shenzhen Third People's Hospital in China. The dynamics of SARS-CoV-2 and antibodies against SARS-CoV-2 were analyzed during hospitalization and after discharge. Results: From January 23 to March 15, 2020, a total of 28 pediatric patients were diagnosed with COVID-19 and were followed for at least 1 month. The median age was 7 years (IQR 3.5-10) and none of the children progressed to severe COVID-19 during hospitalization. Ten patients tested positive for SARS-CoV-2 1 month after discharge while four patients tested positive during the 2nd month after discharge. Only three of 12 children showed detectable immunoglobulin-M (IgM) on day 5, 18, and 21 after illness onset, respectively. Conclusions: COVID-19 disease was relatively mild among children while a number did test positive after discharge from the hospital. Public health initiatives should thus adapt control measures targeted toward children.
Keywords: antibody; clinical features; coronavirus disease 2019 (COVID-19); pediatric; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).