tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2020 Aug 25;7:545.
doi: 10.3389/fmed.2020.00545. eCollection 2020.
Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study
Man Li[SUP] 1 [/SUP], Biao Cheng[SUP] 2 [/SUP], Wen Zeng[SUP] 3 [/SUP], Sichao Chen[SUP] 1 [/SUP], Mengqi Tu[SUP] 4 [/SUP], Meng Wu[SUP] 5 [/SUP], Wei Tong[SUP] 6 [/SUP], Shipei Wang[SUP] 1 [/SUP], Yihui Huang[SUP] 1 [/SUP], Wei Long[SUP] 1 [/SUP], Wei Zhou[SUP] 1 [/SUP], Danyang Chen[SUP] 1 [/SUP], Lin Zhou[SUP] 1 [/SUP], Min Wang[SUP] 1 [/SUP], Haibo Xu[SUP] 4 [/SUP], Aiping Deng[SUP] 2 [/SUP], Zeming Liu[SUP] 1 [/SUP], Liang Guo[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: An outbreak of coronavirus disease (COVID-19) in 2019 in Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial. Methods: A total of 245 adult patients with laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square, Fisher's exact, and the Mann-Whitney U-tests were used to compare the clinical characteristics between the survivors and non-survivors. To explore the risk factors associated with in-hospital death, univariable and multivariable cox regression analyses were used. Results: Of the 245 patients included in this study, 23 (9.4%) died in the hospital. The multivariate regression analysis showed increased odds of in-hospital deaths associated with age, D-dimer levels >1,000 ng/L, platelet count <125, and higher serum creatinine levels. Conclusions: We identified risk factors that show significant association with mortality in adult COVID-19 patients, and our findings provide valuable references for clinicians to identify high-risk patients with COVID-19 at an early stage.
Keywords: COVID-19; SARS-CoV-2; Wuhan; mortality; risk factors.
. 2020 Aug 25;7:545.
doi: 10.3389/fmed.2020.00545. eCollection 2020.
Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study
Man Li[SUP] 1 [/SUP], Biao Cheng[SUP] 2 [/SUP], Wen Zeng[SUP] 3 [/SUP], Sichao Chen[SUP] 1 [/SUP], Mengqi Tu[SUP] 4 [/SUP], Meng Wu[SUP] 5 [/SUP], Wei Tong[SUP] 6 [/SUP], Shipei Wang[SUP] 1 [/SUP], Yihui Huang[SUP] 1 [/SUP], Wei Long[SUP] 1 [/SUP], Wei Zhou[SUP] 1 [/SUP], Danyang Chen[SUP] 1 [/SUP], Lin Zhou[SUP] 1 [/SUP], Min Wang[SUP] 1 [/SUP], Haibo Xu[SUP] 4 [/SUP], Aiping Deng[SUP] 2 [/SUP], Zeming Liu[SUP] 1 [/SUP], Liang Guo[SUP] 1 [/SUP]
Affiliations
- PMID: 32984387
- PMCID: PMC7479842
- DOI: 10.3389/fmed.2020.00545
Abstract
Objectives: An outbreak of coronavirus disease (COVID-19) in 2019 in Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial. Methods: A total of 245 adult patients with laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square, Fisher's exact, and the Mann-Whitney U-tests were used to compare the clinical characteristics between the survivors and non-survivors. To explore the risk factors associated with in-hospital death, univariable and multivariable cox regression analyses were used. Results: Of the 245 patients included in this study, 23 (9.4%) died in the hospital. The multivariate regression analysis showed increased odds of in-hospital deaths associated with age, D-dimer levels >1,000 ng/L, platelet count <125, and higher serum creatinine levels. Conclusions: We identified risk factors that show significant association with mortality in adult COVID-19 patients, and our findings provide valuable references for clinicians to identify high-risk patients with COVID-19 at an early stage.
Keywords: COVID-19; SARS-CoV-2; Wuhan; mortality; risk factors.