tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2022 Dec 6;9:1067082.
doi: 10.3389/fmed.2022.1067082. eCollection 2022.
Clinical and biochemical characteristics of people experiencing post-coronavirus disease 2019-related symptoms: A prospective follow-up investigation
Assim A Alfadda[SUP] 1 2 3 [/SUP], Mohamed Rafiullah[SUP] 1 [/SUP], Mohammad Alkhowaiter[SUP] 3 [/SUP], Naif Alotaibi[SUP] 4 [/SUP], Musa Alzahrani[SUP] 3 5 [/SUP], Khalifa Binkhamis[SUP] 6 [/SUP], Khalid Siddiqui[SUP] 1 [/SUP], Amira Youssef[SUP] 1 [/SUP], Haifa Altalhi[SUP] 7 [/SUP], Ibrahim Almaghlouth[SUP] 8 [/SUP], Mohammed Alarifi[SUP] 9 [/SUP], Saleh Albanyan[SUP] 3 [/SUP], Mohammed F Alosaimi[SUP] 10 [/SUP], Arthur Isnani[SUP] 2 [/SUP], Shaik Sarfaraz Nawaz[SUP] 1 [/SUP], Khalid Alayed[SUP] 3 5 [/SUP]
Affiliations
Abstract
Background: Post-acute coronavirus disease 2019 (COVID-19) syndrome, also known as long COVID, is a prolonged illness after the acute phase of COVID-19. Hospitalized patients were known to have persisting symptoms of fatigue, headache, dyspnea, and anosmia. There is a need to describe the characteristics of individuals with post-COVID-19 symptoms in comparison to the baseline characteristics.
Purpose: To investigate the clinical and biochemical characteristics of people who recovered from COVID-19 after 6 months of discharge from the hospital.
Methods: This was a prospective follow-up investigation of hospitalized and discharged COVID-19 patients. Adult patients admitted to King Saud University Medical City, Riyadh, Saudi Arabia, with laboratory-confirmed COVID-19 and discharged were recruited. The baseline demographic information, comorbidities, vital signs and symptoms, laboratory parameters, COVID-19 therapy, and outcomes were collected from the medical records. Blood samples were collected for cytokines estimation. A detailed interview about signs and symptoms was undertaken during the follow-up.
Results: Half of the followed-up people reported experiencing at least one of the COVID-19-related symptoms. The mean blood pressure was found higher in follow-up. People with the symptoms were characterized by low lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without any post-COVID-19 symptoms. Cytokines IL-8, VEGF, and MCP-1 were higher in people with the most frequent symptoms.
Conclusion: People with post-COVID-19 symptoms were characterized by lower lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without symptoms. Individuals with the most frequent post-COVID-19 symptoms had higher baseline pro-inflammatory, chemotactic, and angiogenic cytokines.
Keywords: COVID-19; PASC; SARS-CoV-2; long COVID; post-COVID-19.
. 2022 Dec 6;9:1067082.
doi: 10.3389/fmed.2022.1067082. eCollection 2022.
Clinical and biochemical characteristics of people experiencing post-coronavirus disease 2019-related symptoms: A prospective follow-up investigation
Assim A Alfadda[SUP] 1 2 3 [/SUP], Mohamed Rafiullah[SUP] 1 [/SUP], Mohammad Alkhowaiter[SUP] 3 [/SUP], Naif Alotaibi[SUP] 4 [/SUP], Musa Alzahrani[SUP] 3 5 [/SUP], Khalifa Binkhamis[SUP] 6 [/SUP], Khalid Siddiqui[SUP] 1 [/SUP], Amira Youssef[SUP] 1 [/SUP], Haifa Altalhi[SUP] 7 [/SUP], Ibrahim Almaghlouth[SUP] 8 [/SUP], Mohammed Alarifi[SUP] 9 [/SUP], Saleh Albanyan[SUP] 3 [/SUP], Mohammed F Alosaimi[SUP] 10 [/SUP], Arthur Isnani[SUP] 2 [/SUP], Shaik Sarfaraz Nawaz[SUP] 1 [/SUP], Khalid Alayed[SUP] 3 5 [/SUP]
Affiliations
- PMID: 36561720
- PMCID: PMC9763306
- DOI: 10.3389/fmed.2022.1067082
Abstract
Background: Post-acute coronavirus disease 2019 (COVID-19) syndrome, also known as long COVID, is a prolonged illness after the acute phase of COVID-19. Hospitalized patients were known to have persisting symptoms of fatigue, headache, dyspnea, and anosmia. There is a need to describe the characteristics of individuals with post-COVID-19 symptoms in comparison to the baseline characteristics.
Purpose: To investigate the clinical and biochemical characteristics of people who recovered from COVID-19 after 6 months of discharge from the hospital.
Methods: This was a prospective follow-up investigation of hospitalized and discharged COVID-19 patients. Adult patients admitted to King Saud University Medical City, Riyadh, Saudi Arabia, with laboratory-confirmed COVID-19 and discharged were recruited. The baseline demographic information, comorbidities, vital signs and symptoms, laboratory parameters, COVID-19 therapy, and outcomes were collected from the medical records. Blood samples were collected for cytokines estimation. A detailed interview about signs and symptoms was undertaken during the follow-up.
Results: Half of the followed-up people reported experiencing at least one of the COVID-19-related symptoms. The mean blood pressure was found higher in follow-up. People with the symptoms were characterized by low lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without any post-COVID-19 symptoms. Cytokines IL-8, VEGF, and MCP-1 were higher in people with the most frequent symptoms.
Conclusion: People with post-COVID-19 symptoms were characterized by lower lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without symptoms. Individuals with the most frequent post-COVID-19 symptoms had higher baseline pro-inflammatory, chemotactic, and angiogenic cytokines.
Keywords: COVID-19; PASC; SARS-CoV-2; long COVID; post-COVID-19.