tetano
Editor, Senior Moderator
Front Immunol
. 2024 Jul 8:15:1359209.
doi: 10.3389/fimmu.2024.1359209. eCollection 2024. Timing of maternal vaccination against COVID-19 for effective protection of neonates: cohort study
Aleksandra Nowakowska[SUP] #[/SUP][SUP] 1 [/SUP], Seung Mi Lee[SUP] #[/SUP][SUP] 2 [/SUP], Minjee Kim[SUP] 1 [/SUP], Jungmin Chun[SUP] 1 [/SUP], Sehyun Kim[SUP] 1 3 [/SUP], Byung Chul Kim[SUP] 4 [/SUP], Hyun Ju In[SUP] 4 [/SUP], Eunji Lee[SUP] 1 [/SUP], Chanyeong Lee[SUP] 1 [/SUP], Hyeondong Lee[SUP] 1 [/SUP], Yuyeon Jang[SUP] 5 [/SUP], Hansam Cho[SUP] 3 [/SUP], Jinha Kim[SUP] 1 [/SUP], Jeesun Lee[SUP] 2 [/SUP], Hee-Jung Lee[SUP] 1 [/SUP], Yoo-Kyoung Lee[SUP] 4 [/SUP], Joong Shin Park[SUP] 2 [/SUP], Young Bong Kim[SUP] 1 3 [/SUP]
Affiliations
Introduction: Although the safety and effectiveness of COVID-19 vaccination during pregnancy have been proven, there is still little data explaining neonatal outcomes of maternal pre-pregnancy vaccination.
Methods: Here, we investigated the impact of vaccination and SARS-CoV-2 infection on maternal-neonate immune response in a cohort study involving 141 pregnant individuals, and defined the importance of maternal COVID-19 vaccination timing for its effectiveness.
Results and discussion: Our data indicate that vertically transferred maternal hybrid immunity provides significantly better antiviral protection for a neonate than either maternal post-infection or post-vaccination immunity alone. Higher neutralization potency among mothers immunized before pregnancy and their newborns highlights the promising role of pre-pregnancy vaccination in neonatal protection. A comparison of neutralizing antibody titers calculated for each dyad suggests that infection and pre-/during-pregnancy vaccination all support transplacental transfer, providing the offspring with strong passive immunity against SARS-CoV-2. Analysis of neutralizing antibody levels in maternal sera collected during pregnancy and later during delivery shows that immunization may exert a positive effect on maternal protection.
Keywords: COVID-19; SARS-CoV-2; maternal vaccination; passive immunity; pregnancy.
. 2024 Jul 8:15:1359209.
doi: 10.3389/fimmu.2024.1359209. eCollection 2024. Timing of maternal vaccination against COVID-19 for effective protection of neonates: cohort study
Aleksandra Nowakowska[SUP] #[/SUP][SUP] 1 [/SUP], Seung Mi Lee[SUP] #[/SUP][SUP] 2 [/SUP], Minjee Kim[SUP] 1 [/SUP], Jungmin Chun[SUP] 1 [/SUP], Sehyun Kim[SUP] 1 3 [/SUP], Byung Chul Kim[SUP] 4 [/SUP], Hyun Ju In[SUP] 4 [/SUP], Eunji Lee[SUP] 1 [/SUP], Chanyeong Lee[SUP] 1 [/SUP], Hyeondong Lee[SUP] 1 [/SUP], Yuyeon Jang[SUP] 5 [/SUP], Hansam Cho[SUP] 3 [/SUP], Jinha Kim[SUP] 1 [/SUP], Jeesun Lee[SUP] 2 [/SUP], Hee-Jung Lee[SUP] 1 [/SUP], Yoo-Kyoung Lee[SUP] 4 [/SUP], Joong Shin Park[SUP] 2 [/SUP], Young Bong Kim[SUP] 1 3 [/SUP]
Affiliations
- PMID: 39040104
- PMCID: PMC11260787
- DOI: 10.3389/fimmu.2024.1359209
Introduction: Although the safety and effectiveness of COVID-19 vaccination during pregnancy have been proven, there is still little data explaining neonatal outcomes of maternal pre-pregnancy vaccination.
Methods: Here, we investigated the impact of vaccination and SARS-CoV-2 infection on maternal-neonate immune response in a cohort study involving 141 pregnant individuals, and defined the importance of maternal COVID-19 vaccination timing for its effectiveness.
Results and discussion: Our data indicate that vertically transferred maternal hybrid immunity provides significantly better antiviral protection for a neonate than either maternal post-infection or post-vaccination immunity alone. Higher neutralization potency among mothers immunized before pregnancy and their newborns highlights the promising role of pre-pregnancy vaccination in neonatal protection. A comparison of neutralizing antibody titers calculated for each dyad suggests that infection and pre-/during-pregnancy vaccination all support transplacental transfer, providing the offspring with strong passive immunity against SARS-CoV-2. Analysis of neutralizing antibody levels in maternal sera collected during pregnancy and later during delivery shows that immunization may exert a positive effect on maternal protection.
Keywords: COVID-19; SARS-CoV-2; maternal vaccination; passive immunity; pregnancy.