tetano
Editor, Senior Moderator
Front Immunol
. 2022 Aug 30;13:988536.
doi: 10.3389/fimmu.2022.988536. eCollection 2022.
The role of B cells in COVID-19 infection and vaccination
Shiru Chen[SUP] 1 2 [/SUP], Fei Guan[SUP] 1 [/SUP], Fabio Candotti[SUP] 3 [/SUP], Kamel Benlagha[SUP] 4 [/SUP], Niels Olsen Saraiva Camara[SUP] 5 [/SUP], Andres A Herrada[SUP] 6 [/SUP], Louisa K James[SUP] 7 [/SUP], Jiahui Lei[SUP] 1 [/SUP], Heather Miller[SUP] 8 [/SUP], Masato Kubo[SUP] 9 [/SUP], Qin Ning[SUP] 10 [/SUP], Chaohong Liu[SUP] 1 [/SUP]
Affiliations
Abstract
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.
Keywords: B cells; COVID-19; SARS-CoV-2; antibody; memory B cells; vaccination.
. 2022 Aug 30;13:988536.
doi: 10.3389/fimmu.2022.988536. eCollection 2022.
The role of B cells in COVID-19 infection and vaccination
Shiru Chen[SUP] 1 2 [/SUP], Fei Guan[SUP] 1 [/SUP], Fabio Candotti[SUP] 3 [/SUP], Kamel Benlagha[SUP] 4 [/SUP], Niels Olsen Saraiva Camara[SUP] 5 [/SUP], Andres A Herrada[SUP] 6 [/SUP], Louisa K James[SUP] 7 [/SUP], Jiahui Lei[SUP] 1 [/SUP], Heather Miller[SUP] 8 [/SUP], Masato Kubo[SUP] 9 [/SUP], Qin Ning[SUP] 10 [/SUP], Chaohong Liu[SUP] 1 [/SUP]
Affiliations
- PMID: 36110861
- PMCID: PMC9468879
- DOI: 10.3389/fimmu.2022.988536
Abstract
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.
Keywords: B cells; COVID-19; SARS-CoV-2; antibody; memory B cells; vaccination.