tetano
Editor, Senior Moderator
Front Immunol
. 2022 Sep 2;13:964976.
doi: 10.3389/fimmu.2022.964976. eCollection 2022.
Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination
Furong Qi[SUP] 1 2 [/SUP], Yingyin Cao[SUP] 1 [/SUP], Shuye Zhang[SUP] 3 [/SUP], Zheng Zhang[SUP] 1 2 4 [/SUP]
Affiliations
Abstract
Amid the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, vaccination and early therapeutic interventions are the most effective means to combat and control the severity of the disease. Host immune responses to SARS-CoV-2 and its variants, particularly adaptive immune responses, should be fully understood to develop improved strategies to implement these measures. Single-cell multi-omic technologies, including flow cytometry, single-cell transcriptomics, and single-cell T-cell receptor (TCR) and B-cell receptor (BCR) profiling, offer a better solution to examine the protective or pathological immune responses and molecular mechanisms associated with SARS-CoV-2 infection, thus providing crucial support for the development of vaccines and therapeutics for COVID-19. Recent reviews have revealed the overall immune landscape of natural SARS-CoV-2 infection, and this review will focus on adaptive immune responses (including T cells and B cells) to SARS-CoV-2 revealed by single-cell multi-omics technologies. In addition, we explore how the single-cell analyses disclose the critical components of immune protection and pathogenesis during SARS-CoV-2 infection through the comparison between the adaptive immune responses induced by natural infection and by vaccination.
Keywords: SARS-CoV-2; adaptive immune response; antibody production; infection; vaccine.
. 2022 Sep 2;13:964976.
doi: 10.3389/fimmu.2022.964976. eCollection 2022.
Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination
Furong Qi[SUP] 1 2 [/SUP], Yingyin Cao[SUP] 1 [/SUP], Shuye Zhang[SUP] 3 [/SUP], Zheng Zhang[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 36119105
- PMCID: PMC9478577
- DOI: 10.3389/fimmu.2022.964976
Abstract
Amid the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, vaccination and early therapeutic interventions are the most effective means to combat and control the severity of the disease. Host immune responses to SARS-CoV-2 and its variants, particularly adaptive immune responses, should be fully understood to develop improved strategies to implement these measures. Single-cell multi-omic technologies, including flow cytometry, single-cell transcriptomics, and single-cell T-cell receptor (TCR) and B-cell receptor (BCR) profiling, offer a better solution to examine the protective or pathological immune responses and molecular mechanisms associated with SARS-CoV-2 infection, thus providing crucial support for the development of vaccines and therapeutics for COVID-19. Recent reviews have revealed the overall immune landscape of natural SARS-CoV-2 infection, and this review will focus on adaptive immune responses (including T cells and B cells) to SARS-CoV-2 revealed by single-cell multi-omics technologies. In addition, we explore how the single-cell analyses disclose the critical components of immune protection and pathogenesis during SARS-CoV-2 infection through the comparison between the adaptive immune responses induced by natural infection and by vaccination.
Keywords: SARS-CoV-2; adaptive immune response; antibody production; infection; vaccine.