tetano
Editor, Senior Moderator
Front Immunol
. 2023 Jan 24;14:1072142.
doi: 10.3389/fimmu.2023.1072142. eCollection 2023.
Silent neonatal influenza A virus infection primes systemic antimicrobial immunity
Anna Sophie Heinemann[SUP] 1 [/SUP], Jan Lennart Stalp[SUP] 1 [/SUP], João Pedro Pereira Bonifacio[SUP] 2 [/SUP], Filo Silva[SUP] 2 [/SUP], Maike Willers[SUP] 1 [/SUP], Julia Heckmann[SUP] 1 [/SUP], Beate Fehlhaber[SUP] 1 [/SUP], Lena Völlger[SUP] 1 [/SUP], Dina Raafat[SUP] 3 4 [/SUP], Nicole Normann[SUP] 3 [/SUP], Andreas Klos[SUP] 5 [/SUP], Gesine Hansen[SUP] 1 6 [/SUP], Mirco Schmolke[SUP] 2 7 [/SUP], Dorothee Viemann[SUP] 1 6 7 8 9 [/SUP]
Affiliations
Abstract
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among children below five years of age. Importantly, this is a time, when immunological imprinting takes place. Whether early-life infections with IAV affect the development of antimicrobial immunity is unknown. Using a preclinical mouse model, we demonstrate here that silent neonatal influenza infections have a remote beneficial impact on the later control of systemic juvenile-onset and adult-onset infections with an unrelated pathogen, Staphylococcus aureus, due to improved pathogen clearance and clinical resolution. Strategic vaccination with a live attenuated IAV vaccine elicited a similar protection phenotype. Mechanistically, the IAV priming effect primarily targets antimicrobial functions of the developing innate immune system including increased antimicrobial plasma activity and enhanced phagocyte functions and antigen-presenting properties at mucosal sites. Our results suggest a long-term benefit from an exposure to IAV during the neonatal phase, which might be exploited by strategic vaccination against influenza early in life to enforce the host's resistance to later bacterial infections.
Keywords: Staphylococcus aureus; antimicrobial immunity; influenza A virus; influenza vaccination; innate immunity training; neonate; sepsis.
. 2023 Jan 24;14:1072142.
doi: 10.3389/fimmu.2023.1072142. eCollection 2023.
Silent neonatal influenza A virus infection primes systemic antimicrobial immunity
Anna Sophie Heinemann[SUP] 1 [/SUP], Jan Lennart Stalp[SUP] 1 [/SUP], João Pedro Pereira Bonifacio[SUP] 2 [/SUP], Filo Silva[SUP] 2 [/SUP], Maike Willers[SUP] 1 [/SUP], Julia Heckmann[SUP] 1 [/SUP], Beate Fehlhaber[SUP] 1 [/SUP], Lena Völlger[SUP] 1 [/SUP], Dina Raafat[SUP] 3 4 [/SUP], Nicole Normann[SUP] 3 [/SUP], Andreas Klos[SUP] 5 [/SUP], Gesine Hansen[SUP] 1 6 [/SUP], Mirco Schmolke[SUP] 2 7 [/SUP], Dorothee Viemann[SUP] 1 6 7 8 9 [/SUP]
Affiliations
- PMID: 36761727
- PMCID: PMC9902881
- DOI: 10.3389/fimmu.2023.1072142
Abstract
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among children below five years of age. Importantly, this is a time, when immunological imprinting takes place. Whether early-life infections with IAV affect the development of antimicrobial immunity is unknown. Using a preclinical mouse model, we demonstrate here that silent neonatal influenza infections have a remote beneficial impact on the later control of systemic juvenile-onset and adult-onset infections with an unrelated pathogen, Staphylococcus aureus, due to improved pathogen clearance and clinical resolution. Strategic vaccination with a live attenuated IAV vaccine elicited a similar protection phenotype. Mechanistically, the IAV priming effect primarily targets antimicrobial functions of the developing innate immune system including increased antimicrobial plasma activity and enhanced phagocyte functions and antigen-presenting properties at mucosal sites. Our results suggest a long-term benefit from an exposure to IAV during the neonatal phase, which might be exploited by strategic vaccination against influenza early in life to enforce the host's resistance to later bacterial infections.
Keywords: Staphylococcus aureus; antimicrobial immunity; influenza A virus; influenza vaccination; innate immunity training; neonate; sepsis.