tetano
Editor, Senior Moderator
Front Immunol
. 2024 Aug 21:15:1412918.
doi: 10.3389/fimmu.2024.1412918. eCollection 2024. SARS-CoV-2 spike protein antibody titers after the fourth dose of BNT162b2 vaccine among Japanese patients undergoing hemodialysis: a single-center study
Shun Watanabe[SUP] 1 [/SUP], Toyoaki Sawano[SUP] 2 3 [/SUP], Hiroaki Saito[SUP] 3 4 [/SUP], Akihiko Ozaki[SUP] 5 [/SUP], Masatoshi Wakui[SUP] 6 [/SUP], Tianchen Zhao[SUP] 3 [/SUP], Chika Yamamoto[SUP] 3 [/SUP], Yurie Kobashi[SUP] 3 7 [/SUP], Takeshi Kawamura[SUP] 8 9 [/SUP], Akira Sugiyama[SUP] 8 [/SUP], Aya Nakayama[SUP] 8 [/SUP], Yudai Kaneko[SUP] 9 10 [/SUP], Hiroaki Shimmura[SUP] 1 [/SUP], Masaharu Tsubokura[SUP] 3 [/SUP]
Affiliations
Patients undergoing hemodialysis are particularly vulnerable to severe outcomes of SARS-CoV-2 infection, with mortality rates higher than that of the general population. Vaccination reduces the risk of adverse outcomes, with booster doses being particularly beneficial. However, limited data are available on the effectiveness of subsequent vaccinations or their effect on increasing antibody levels. This single-center study aimed to investigate changes in SARS-CoV-2 IgG antibody titers following the fourth vaccination among 28 patients undergoing hemodialysis. Blood tests were conducted at various intervals post-vaccination, with a focus on identifying factors associated with antibody levels. The IgG antibody levels rapidly increased by Day 7 post-vaccination, with a median time to peak of 11 days. Antibody titers tended to be higher in male patients than in female patients. This study sheds light on the immune response to the fourth vaccination in patients undergoing hemodialysis. As this study included a small sample size, with a short observation period, further research is warranted to comprehensively understand the effectiveness of vaccination and the benefits of additional doses of vaccine.
Keywords: BNT162b2 vaccine; IgG antibody titers; SARS-CoV-2; chronic kidney failure; fourth dose of vaccine; hemodialysis.
. 2024 Aug 21:15:1412918.
doi: 10.3389/fimmu.2024.1412918. eCollection 2024. SARS-CoV-2 spike protein antibody titers after the fourth dose of BNT162b2 vaccine among Japanese patients undergoing hemodialysis: a single-center study
Shun Watanabe[SUP] 1 [/SUP], Toyoaki Sawano[SUP] 2 3 [/SUP], Hiroaki Saito[SUP] 3 4 [/SUP], Akihiko Ozaki[SUP] 5 [/SUP], Masatoshi Wakui[SUP] 6 [/SUP], Tianchen Zhao[SUP] 3 [/SUP], Chika Yamamoto[SUP] 3 [/SUP], Yurie Kobashi[SUP] 3 7 [/SUP], Takeshi Kawamura[SUP] 8 9 [/SUP], Akira Sugiyama[SUP] 8 [/SUP], Aya Nakayama[SUP] 8 [/SUP], Yudai Kaneko[SUP] 9 10 [/SUP], Hiroaki Shimmura[SUP] 1 [/SUP], Masaharu Tsubokura[SUP] 3 [/SUP]
Affiliations
- PMID: 39238641
- PMCID: PMC11375752
- DOI: 10.3389/fimmu.2024.1412918
Patients undergoing hemodialysis are particularly vulnerable to severe outcomes of SARS-CoV-2 infection, with mortality rates higher than that of the general population. Vaccination reduces the risk of adverse outcomes, with booster doses being particularly beneficial. However, limited data are available on the effectiveness of subsequent vaccinations or their effect on increasing antibody levels. This single-center study aimed to investigate changes in SARS-CoV-2 IgG antibody titers following the fourth vaccination among 28 patients undergoing hemodialysis. Blood tests were conducted at various intervals post-vaccination, with a focus on identifying factors associated with antibody levels. The IgG antibody levels rapidly increased by Day 7 post-vaccination, with a median time to peak of 11 days. Antibody titers tended to be higher in male patients than in female patients. This study sheds light on the immune response to the fourth vaccination in patients undergoing hemodialysis. As this study included a small sample size, with a short observation period, further research is warranted to comprehensively understand the effectiveness of vaccination and the benefits of additional doses of vaccine.
Keywords: BNT162b2 vaccine; IgG antibody titers; SARS-CoV-2; chronic kidney failure; fourth dose of vaccine; hemodialysis.