tetano
Editor, Senior Moderator
Front Immunol
. 2022 Jun 14;13:888385.
doi: 10.3389/fimmu.2022.888385. eCollection 2022.
Risk Factors for Weak Antibody Response of SARS-CoV-2 Vaccine in Adult Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
Kezhen Zong[SUP] 1 [/SUP], Dadi Peng[SUP] 1 [/SUP], Hang Yang[SUP] 1 [/SUP], Zuotian Huang[SUP] 1 [/SUP], Yunhai Luo[SUP] 1 [/SUP], Yihua Wang[SUP] 1 [/SUP], Song Xiang[SUP] 1 [/SUP], Tingting Li[SUP] 1 [/SUP], Tong Mou[SUP] 1 [/SUP], Zhongjun Wu[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: This is the first systematic review and meta-analysis to determine the factors that contribute to poor antibody response in organ transplant recipients after receiving the 2-dose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.
Method: Data was obtained from Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM). Studies reporting factors associated with antibody responses to the 2-dose SARS-CoV-2 vaccine in solid organ transplant recipients were included in our study based on the inclusion and exclusion criteria. Two researchers completed the literature search, screening, and data extraction. Randomized models were used to obtain results. Egger's test was performed to determine publication bias. Sensitivity analysis was performed to determine the stability of the result. The heterogeneity was determined using the Galbraith plot and subgroup analysis.
Results: A total of 29 studies were included in the present study. The factors included living donor, BNT162b2, tacrolimus, cyclosporine, antimetabolite, mycophenolic acid (MPA) or mycophenolate mofetil (MMF), azathioprine, corticosteroids, high-dose corticosteroids, belatacept, mammalian target of rapamycin (mTOR) inhibitor, tritherapy, age, estimated glomerular filtration rate (eGFR), hemoglobin, and tacrolimus level were significantly different. Multivariate analysis showed significant differences in age, diabetes mellitus, MPA or MMF, high-dose corticosteroids, tritherapy, and eGFR.
Conclusion: The possible independent risk factors for negative antibody response in patients with organ transplants who received the 2-dose SARS-CoV-2 vaccine include age, diabetes mellitus, low eGFR, MPA or MMF, high-dose corticosteroids, and triple immunosuppression therapy. mTOR inhibitor can be a protective factor against weak antibody response.
Systematic review registration: PROSPERO, identifier CRD42021257965.
Keywords: COVID19; SARS-CoV-2 vaccine; antibody response; meta-analysis; organ transplantation; risk factors.
. 2022 Jun 14;13:888385.
doi: 10.3389/fimmu.2022.888385. eCollection 2022.
Risk Factors for Weak Antibody Response of SARS-CoV-2 Vaccine in Adult Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
Kezhen Zong[SUP] 1 [/SUP], Dadi Peng[SUP] 1 [/SUP], Hang Yang[SUP] 1 [/SUP], Zuotian Huang[SUP] 1 [/SUP], Yunhai Luo[SUP] 1 [/SUP], Yihua Wang[SUP] 1 [/SUP], Song Xiang[SUP] 1 [/SUP], Tingting Li[SUP] 1 [/SUP], Tong Mou[SUP] 1 [/SUP], Zhongjun Wu[SUP] 1 [/SUP]
Affiliations
- PMID: 35774786
- PMCID: PMC9237843
- DOI: 10.3389/fimmu.2022.888385
Abstract
Objective: This is the first systematic review and meta-analysis to determine the factors that contribute to poor antibody response in organ transplant recipients after receiving the 2-dose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.
Method: Data was obtained from Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM). Studies reporting factors associated with antibody responses to the 2-dose SARS-CoV-2 vaccine in solid organ transplant recipients were included in our study based on the inclusion and exclusion criteria. Two researchers completed the literature search, screening, and data extraction. Randomized models were used to obtain results. Egger's test was performed to determine publication bias. Sensitivity analysis was performed to determine the stability of the result. The heterogeneity was determined using the Galbraith plot and subgroup analysis.
Results: A total of 29 studies were included in the present study. The factors included living donor, BNT162b2, tacrolimus, cyclosporine, antimetabolite, mycophenolic acid (MPA) or mycophenolate mofetil (MMF), azathioprine, corticosteroids, high-dose corticosteroids, belatacept, mammalian target of rapamycin (mTOR) inhibitor, tritherapy, age, estimated glomerular filtration rate (eGFR), hemoglobin, and tacrolimus level were significantly different. Multivariate analysis showed significant differences in age, diabetes mellitus, MPA or MMF, high-dose corticosteroids, tritherapy, and eGFR.
Conclusion: The possible independent risk factors for negative antibody response in patients with organ transplants who received the 2-dose SARS-CoV-2 vaccine include age, diabetes mellitus, low eGFR, MPA or MMF, high-dose corticosteroids, and triple immunosuppression therapy. mTOR inhibitor can be a protective factor against weak antibody response.
Systematic review registration: PROSPERO, identifier CRD42021257965.
Keywords: COVID19; SARS-CoV-2 vaccine; antibody response; meta-analysis; organ transplantation; risk factors.