tetano
Editor, Senior Moderator
Front Immunol
. 2022 Jul 26;13:944713.
doi: 10.3389/fimmu.2022.944713. eCollection 2022.
Post-vaccination T cell immunity to omicron
Henning Jacobsen[SUP] 1 [/SUP], Viviana Cobos Jiménez[SUP] 2 3 [/SUP], Ioannis Sitaras[SUP] 4 [/SUP], Naor Bar-Zeev[SUP] 5 [/SUP], Luka Čičin-Šain[SUP] 1 6 7 [/SUP], Melissa M Higdon[SUP] 5 [/SUP], Maria Deloria-Knoll[SUP] 5 [/SUP]
Affiliations
Abstract
In late 2021, the omicron variant of SARS Coronavirus 2 (SARS-CoV-2) emerged and replaced the previously dominant delta strain. Effectiveness of COVID-19 vaccines against omicron has been challenging to estimate in clinical studies or is not available for all vaccines or populations of interest. T cell function can be predictive of vaccine longevity and effectiveness against disease, likely in a more robust way than antibody neutralization. In this mini review, we summarize the evidence on T cell immunity against omicron including effects of boosters, homologous versus heterologous regimens, hybrid immunity, memory responses and vaccine product. Overall, T cell reactivity in post-vaccine specimens is largely preserved against omicron, indicating that vaccines utilizing the parental antigen continue to be protective against disease caused by the omicron variant.
Keywords: COVID-19; SARS-CoV-2; T cell; omicron; vaccine.
. 2022 Jul 26;13:944713.
doi: 10.3389/fimmu.2022.944713. eCollection 2022.
Post-vaccination T cell immunity to omicron
Henning Jacobsen[SUP] 1 [/SUP], Viviana Cobos Jiménez[SUP] 2 3 [/SUP], Ioannis Sitaras[SUP] 4 [/SUP], Naor Bar-Zeev[SUP] 5 [/SUP], Luka Čičin-Šain[SUP] 1 6 7 [/SUP], Melissa M Higdon[SUP] 5 [/SUP], Maria Deloria-Knoll[SUP] 5 [/SUP]
Affiliations
- PMID: 35990661
- PMCID: PMC9386871
- DOI: 10.3389/fimmu.2022.944713
Abstract
In late 2021, the omicron variant of SARS Coronavirus 2 (SARS-CoV-2) emerged and replaced the previously dominant delta strain. Effectiveness of COVID-19 vaccines against omicron has been challenging to estimate in clinical studies or is not available for all vaccines or populations of interest. T cell function can be predictive of vaccine longevity and effectiveness against disease, likely in a more robust way than antibody neutralization. In this mini review, we summarize the evidence on T cell immunity against omicron including effects of boosters, homologous versus heterologous regimens, hybrid immunity, memory responses and vaccine product. Overall, T cell reactivity in post-vaccine specimens is largely preserved against omicron, indicating that vaccines utilizing the parental antigen continue to be protective against disease caused by the omicron variant.
Keywords: COVID-19; SARS-CoV-2; T cell; omicron; vaccine.