tetano
Editor, Senior Moderator
Front Immunol
. 2020 Sep 17;11:564925.
doi: 10.3389/fimmu.2020.564925. eCollection 2020.
Immunopathogenesis of COVID-19: Summary and Possible Interventions
Francois Henri Jacques[SUP] 1 [/SUP], Erik Apedaile[SUP] 1 [/SUP]
Affiliations
Abstract
Since the onset of the COVID-19 pandemic in the fall of 2019 over 4 million people have been infected and over 280,000 have died (1). Information about the SARS-CoV2 virus is evolving rapidly. At this time there are no interventions proven to be effective for cases infected with SARS-CoV2. Current knowledge about the clinical and laboratory manifestations of COVID-19 infection is reviewed and combined with knowledge about the immunopathogenic mechanisms of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV1) and Middle East Respiratory Syndrome (MERS) to formulate theories and suggest possible therapeutic interventions. SARS-CoV2 immunopathogenic mechanisms vary from immunosuppression that initially enables viral escape to a hyperinflammatory immune response. Ultimately therapeutic intervention will be phase dependent.
Keywords: COVID-19; hyperinflammation; immunology; immunosuppression; intervention.
. 2020 Sep 17;11:564925.
doi: 10.3389/fimmu.2020.564925. eCollection 2020.
Immunopathogenesis of COVID-19: Summary and Possible Interventions
Francois Henri Jacques[SUP] 1 [/SUP], Erik Apedaile[SUP] 1 [/SUP]
Affiliations
- PMID: 33072103
- PMCID: PMC7533543
- DOI: 10.3389/fimmu.2020.564925
Abstract
Since the onset of the COVID-19 pandemic in the fall of 2019 over 4 million people have been infected and over 280,000 have died (1). Information about the SARS-CoV2 virus is evolving rapidly. At this time there are no interventions proven to be effective for cases infected with SARS-CoV2. Current knowledge about the clinical and laboratory manifestations of COVID-19 infection is reviewed and combined with knowledge about the immunopathogenic mechanisms of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV1) and Middle East Respiratory Syndrome (MERS) to formulate theories and suggest possible therapeutic interventions. SARS-CoV2 immunopathogenic mechanisms vary from immunosuppression that initially enables viral escape to a hyperinflammatory immune response. Ultimately therapeutic intervention will be phase dependent.
Keywords: COVID-19; hyperinflammation; immunology; immunosuppression; intervention.