tetano
Editor, Senior Moderator
Front Immunol
. 2024 Aug 20:15:1437267.
doi: 10.3389/fimmu.2024.1437267. eCollection 2024. Immunogenicity and safety of different combinations involving a third booster dose of SARS-CoV-2 inactivated vaccine, inactivated quadrivalent influenza vaccine, and 23-valent pneumococcal polysaccharide vaccine in adults aged ≥60 years: a phase 4, randomized, open-label study
Shuang Bai[SUP] 1 [/SUP], Shanshan Zhou[SUP] 1 [/SUP], Junnan Zhang[SUP] 1 [/SUP], Weixin Chen[SUP] 1 [/SUP], Min Lv[SUP] 1 [/SUP], Jian Wang[SUP] 1 [/SUP], Ao Zhang[SUP] 1 [/SUP], Jiang Wu[SUP] 1 [/SUP], Wei Zhao[SUP] 1 [/SUP]
Affiliations
Background: Concomitant administration of COVID-19, influenza, and pneumococcal vaccines could reduce the burden on healthcare systems. However, the immunogenicity and safety of various combinations of a third booster dose of SARS-CoV-2 inactivated vaccine (CoronaVac), inactivated quadrivalent influenza vaccine (IIV4), and 23-valent pneumococcal polysaccharide vaccine (PPV23), particularly in different age groups, is still unknown.
Methods: A phase 4, randomized, open-label, controlled trial was conducted in Beijing, China. 636 healthy adults were divided into two age groups (18-59 and ≥60 years) and randomized equally into three groups: CoronaVac and IIV4 followed by PPV23; CoronaVac and PPV23 followed by IIV4; or CoronaVac followed by IIV4 and PPV23, with a 28-day interval between vaccinations. Immunogenicity was evaluated by measuring antibody titers, and safety was monitored. ClinicalTrials.gov Identifier: NCT05298800.
Results: Co-administration of a third dose of CoronaVac, IIV4, and PPV23 in any combination was safe. Among adults aged 18-59, co-administration with PPV23 maintained non-inferiority of antibody levels for CoronaVac and IIV4, despite a slight reduction in antibody responses. This reduction was not observed in participants ≥60 years. Furthermore, co-administration of IIV4 and PPV23 affected seroconversion rates for both vaccines.
Conclusions: Co-administration of the third dose of SARS-CoV-2 inactivated vaccine with the influenza vaccine, followed by PPV23, may be optimal for adults aged 18-59. In adults ≥60, all vaccine combinations were immunogenic, suggesting a flexible vaccination approach. Since antibody measurements were taken 28 days post-vaccination, ongoing surveillance is essential to assess the longevity of the immune responses.
Keywords: 23-valent pneumococcal polysaccharide vaccine; concomitant administration; inactivated SARS-CoV-2 vaccine; influenza vaccine; third booster dose.
. 2024 Aug 20:15:1437267.
doi: 10.3389/fimmu.2024.1437267. eCollection 2024. Immunogenicity and safety of different combinations involving a third booster dose of SARS-CoV-2 inactivated vaccine, inactivated quadrivalent influenza vaccine, and 23-valent pneumococcal polysaccharide vaccine in adults aged ≥60 years: a phase 4, randomized, open-label study
Shuang Bai[SUP] 1 [/SUP], Shanshan Zhou[SUP] 1 [/SUP], Junnan Zhang[SUP] 1 [/SUP], Weixin Chen[SUP] 1 [/SUP], Min Lv[SUP] 1 [/SUP], Jian Wang[SUP] 1 [/SUP], Ao Zhang[SUP] 1 [/SUP], Jiang Wu[SUP] 1 [/SUP], Wei Zhao[SUP] 1 [/SUP]
Affiliations
- PMID: 39229259
- PMCID: PMC11368774
- DOI: 10.3389/fimmu.2024.1437267
Background: Concomitant administration of COVID-19, influenza, and pneumococcal vaccines could reduce the burden on healthcare systems. However, the immunogenicity and safety of various combinations of a third booster dose of SARS-CoV-2 inactivated vaccine (CoronaVac), inactivated quadrivalent influenza vaccine (IIV4), and 23-valent pneumococcal polysaccharide vaccine (PPV23), particularly in different age groups, is still unknown.
Methods: A phase 4, randomized, open-label, controlled trial was conducted in Beijing, China. 636 healthy adults were divided into two age groups (18-59 and ≥60 years) and randomized equally into three groups: CoronaVac and IIV4 followed by PPV23; CoronaVac and PPV23 followed by IIV4; or CoronaVac followed by IIV4 and PPV23, with a 28-day interval between vaccinations. Immunogenicity was evaluated by measuring antibody titers, and safety was monitored. ClinicalTrials.gov Identifier: NCT05298800.
Results: Co-administration of a third dose of CoronaVac, IIV4, and PPV23 in any combination was safe. Among adults aged 18-59, co-administration with PPV23 maintained non-inferiority of antibody levels for CoronaVac and IIV4, despite a slight reduction in antibody responses. This reduction was not observed in participants ≥60 years. Furthermore, co-administration of IIV4 and PPV23 affected seroconversion rates for both vaccines.
Conclusions: Co-administration of the third dose of SARS-CoV-2 inactivated vaccine with the influenza vaccine, followed by PPV23, may be optimal for adults aged 18-59. In adults ≥60, all vaccine combinations were immunogenic, suggesting a flexible vaccination approach. Since antibody measurements were taken 28 days post-vaccination, ongoing surveillance is essential to assess the longevity of the immune responses.
Keywords: 23-valent pneumococcal polysaccharide vaccine; concomitant administration; inactivated SARS-CoV-2 vaccine; influenza vaccine; third booster dose.