tetano
Editor, Senior Moderator
Front Immunol
. 2021 Nov 22;12:771242.
doi: 10.3389/fimmu.2021.771242. eCollection 2021.
Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
Yandi Zhang[SUP] 1 [/SUP], Jo-Lewis Banga Ndzouboukou[SUP] 1 [/SUP], Mengze Gan[SUP] 1 [/SUP], Xiaosong Lin[SUP] 1 [/SUP], Xionglin Fan[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants.
Keywords: COVID-19; SARS-CoV-2 variants; epidemiology; immune evasive; vaccine efficacy.
. 2021 Nov 22;12:771242.
doi: 10.3389/fimmu.2021.771242. eCollection 2021.
Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
Yandi Zhang[SUP] 1 [/SUP], Jo-Lewis Banga Ndzouboukou[SUP] 1 [/SUP], Mengze Gan[SUP] 1 [/SUP], Xiaosong Lin[SUP] 1 [/SUP], Xionglin Fan[SUP] 1 [/SUP]
Affiliations
- PMID: 34880867
- PMCID: PMC8645832
- DOI: 10.3389/fimmu.2021.771242
Abstract
Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants.
Keywords: COVID-19; SARS-CoV-2 variants; epidemiology; immune evasive; vaccine efficacy.