tetano
Editor, Senior Moderator
Front Immunol
. 2024 Oct 7:15:1477721.
doi: 10.3389/fimmu.2024.1477721. eCollection 2024. Dynamic changes of neutralizing antibody and memory T cell responses six months post Omicron XBB reinfection
Xin-Jing Zhao[SUP] #[/SUP][SUP] 1 2 [/SUP], Xin-Lou Li[SUP] #[/SUP][SUP] 3 [/SUP], Sheng Zhang[SUP] 1 [/SUP], Jin-Jin Chen[SUP] 1 [/SUP], Wei-Chao Zhao[SUP] 4 [/SUP], Na-Na Wu[SUP] 4 [/SUP], Rui-Juan Wang[SUP] 4 [/SUP], Qiang Xu[SUP] 1 [/SUP], Chen-Long Lv[SUP] 1 [/SUP], Bao-Gui Jiang[SUP] 1 [/SUP], Guo-Lin Wang[SUP] 1 [/SUP], Li-Qun Fang[SUP] 1 2 [/SUP]
Affiliations
Introduction: With the continued prevalence of COVID-19, repeated infection caused by SARS-CoV-2 has become common. However, studies on immune persistence post Omicron XBB reinfection are limited.
Methods: We prospectively studied the durability and cross-reactivity of neutralizing antibodies (NAbs) and T cell responses among 20 subjects who suffered Omicron BA.5 infection with or without Omicron XBB reinfection over 6-month through the pseudovirus neutralization test and the fluorospot assay.
Results: NAbs against EG.5.1, BA.2.86, and JN.1 subvariants were decreased and undetectable at 6-month post Omicron BA.5 infection, while those elicited by Omicron XBB reinfection were significant increased and remained detectable against all detected variants within 6-month. Furthermore, in subjects with Omicron XBB reinfection, memory T cell responses could cross-recognized wild-type and Omicron spike peptides and reached peak at 3-month. Interestingly, comparable robust T cell responses were observed among non-seroconverted subjects post Omicron XBB exposure.
Conclusion: Though the NAbs against various emerging Omicron subvariants elicited by Omicron XBB reinfection can persist for at least 6-month, the HCWs should strengthen personal protection and timely be immunized with updated vaccines upon current circulating variants or conserved T epitope.
Keywords: Omicron XBB reinfection; cross-recognition; immune persistence; memory T cell responses; neutralizing antibody.
. 2024 Oct 7:15:1477721.
doi: 10.3389/fimmu.2024.1477721. eCollection 2024. Dynamic changes of neutralizing antibody and memory T cell responses six months post Omicron XBB reinfection
Xin-Jing Zhao[SUP] #[/SUP][SUP] 1 2 [/SUP], Xin-Lou Li[SUP] #[/SUP][SUP] 3 [/SUP], Sheng Zhang[SUP] 1 [/SUP], Jin-Jin Chen[SUP] 1 [/SUP], Wei-Chao Zhao[SUP] 4 [/SUP], Na-Na Wu[SUP] 4 [/SUP], Rui-Juan Wang[SUP] 4 [/SUP], Qiang Xu[SUP] 1 [/SUP], Chen-Long Lv[SUP] 1 [/SUP], Bao-Gui Jiang[SUP] 1 [/SUP], Guo-Lin Wang[SUP] 1 [/SUP], Li-Qun Fang[SUP] 1 2 [/SUP]
Affiliations
- PMID: 39434881
- PMCID: PMC11491401
- DOI: 10.3389/fimmu.2024.1477721
Introduction: With the continued prevalence of COVID-19, repeated infection caused by SARS-CoV-2 has become common. However, studies on immune persistence post Omicron XBB reinfection are limited.
Methods: We prospectively studied the durability and cross-reactivity of neutralizing antibodies (NAbs) and T cell responses among 20 subjects who suffered Omicron BA.5 infection with or without Omicron XBB reinfection over 6-month through the pseudovirus neutralization test and the fluorospot assay.
Results: NAbs against EG.5.1, BA.2.86, and JN.1 subvariants were decreased and undetectable at 6-month post Omicron BA.5 infection, while those elicited by Omicron XBB reinfection were significant increased and remained detectable against all detected variants within 6-month. Furthermore, in subjects with Omicron XBB reinfection, memory T cell responses could cross-recognized wild-type and Omicron spike peptides and reached peak at 3-month. Interestingly, comparable robust T cell responses were observed among non-seroconverted subjects post Omicron XBB exposure.
Conclusion: Though the NAbs against various emerging Omicron subvariants elicited by Omicron XBB reinfection can persist for at least 6-month, the HCWs should strengthen personal protection and timely be immunized with updated vaccines upon current circulating variants or conserved T epitope.
Keywords: Omicron XBB reinfection; cross-recognition; immune persistence; memory T cell responses; neutralizing antibody.